Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates

Analytical Biochemistry

Volumn 486, Issue , 2015, Pages 75-77

  Ghavami, Ahmad ^a   Labbé, Geneviève ^a   Brem, Jürgen ^b   Goodfellow, Valerie J ^a   Marrone, Laura ^a   Tanner, Carol A ^a   King, Dustin T ^c   Lam, Melinda ^a   Strynadka, Natalie C J ^c   Pillai, Dylan R ^d   Siemann, Stefan ^e   Spencer, James ^f   Schofield, Christopher J ^b   Dmitrienko, Gary I ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e LAURENTIAN UNIVERSITY   (Canada)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Antibiotic resistance detection; Chromogenic cephalosporin; Nitrocefin analogues; Lactamase

Indexed keywords

BACTERIA; HYDROLYSIS;

ABSORBANCE SPECTRUM; ANTIBIOTIC RESISTANCE; DRUG DISCOVERY; GRAM-NEGATIVE BACTERIA; IN-VITRO; LACTAMASES; NITROCEFIN;

ANTIBIOTICS;

BETA LACTAMASE; NITROCEFIN; UNCLASSIFIED DRUG; UW 154; UW 57; UW 58; CEPHALOSPORIN DERIVATIVE;

ARTICLE; BACTERIAL GROWTH; DRUG SYNTHESIS; ENZYME ACTIVITY; GRAM NEGATIVE BACTERIUM; HYDROLYSIS; ISOMERIZATION; NONHUMAN; PRIORITY JOURNAL; BIOCATALYSIS; CHEMISTRY; KINETICS; METABOLISM; PRECLINICAL STUDY; SYNTHESIS;

NEGIBACTERIA;

BETA-LACTAMASES; BIOCATALYSIS; CEPHALOSPORINS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG EVALUATION, PRECLINICAL; HYDROLYSIS; KINETICS;

EID: 84937806432     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2015.06.032     Document Type: Article

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