Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy

PLoS Genetics

Volumn 11, Issue 6, 2015, Pages

  Asinof, Samuel K ^a   Sukoff Rizzo, Stacey J ^a   Buckley, Alexandra R ^b   Beyer, Barbara J ^a   Letts, Verity A ^a   Frankel, Wayne N ^a   Boumil, Rebecca M ^a  

^a JACKSON LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN I;

ADULT; ALLELE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BEHAVIOR DISORDER; COGNITIVE DEFECT; COMORBIDITY; COMPULSION; CONTROLLED STUDY; DEPRESSION; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; DISEASE SEVERITY; DNM1 GENE; DOPAMINERGIC NERVE CELL; EXPLORATORY BEHAVIOR; FEMALE; FOREBRAIN; GENE; GENE DELETION; GENETIC MANIPULATION; GENETIC VARIABILITY; LENNOX GASTAUT SYNDROME; LETHALITY; LOCOMOTION; MALE; MOUSE; NERVE CELL; NONHUMAN; ONSET AGE; PATHOPHYSIOLOGY; PHENOTYPE; PLEIOTROPY; SEIZURE; SEX DIFFERENCE; ANIMAL; DISEASE MODEL; ELECTROENCEPHALOGRAPHY; EPILEPSY; GENETICS; HUMAN; INFANT; METABOLISM; MORTALITY; MUTANT MOUSE STRAIN; PATHOLOGY; SPASMS, INFANTILE; SYNAPTIC TRANSMISSION;

ANIMALIA; MUS;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DYNAMIN I; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; GENE DELETION; HUMANS; INFANT; LENNOX GASTAUT SYNDROME; MALE; MICE, MUTANT STRAINS; NEURONS; PHENOTYPE; PROSENCEPHALON; SPASMS, INFANTILE; SYNAPTIC TRANSMISSION;

EID: 84937784105     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005347     Document Type: Article

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