Overexpression of Pref-1 in pancreatic islet β-cells in mice causes hyperinsulinemia with increased islet mass and insulin secretion

Biochemical and Biophysical Research Communications

Volumn 461, Issue 4, 2015, Pages 630-635

  Wang, Yuhui ^a   Lee, Kichoon ^a   Moon, Yang Soo ^a   Ahmadian, Maryam ^a   Kim, Kee Hong ^a   Roder, Karim ^a   Kang, Chulho ^b   Sul, Hei Sook ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California Berkeley   (United States)

Author keywords

Diabetes; Hyperinsulinemia; Insulin secretion; Islet cells; Pref 1 Dlk1; Transgenic mice

Indexed keywords

DLK1 PROTEIN, MOUSE; INSULIN; SIGNAL PEPTIDE;

ANIMAL; C57BL MOUSE; CELL PROLIFERATION; FEMALE; HYPERINSULINISM; INSULIN RESISTANCE; METABOLISM; MOUSE; PANCREAS ISLET BETA CELL; PATHOLOGY; SECRETION (PROCESS); TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; CELL PROLIFERATION; FEMALE; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; UP-REGULATION;

EID: 84937765391     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.04.078     Document Type: Article

References (21)

1. C.M. Smas, L. Chen, and H.S. Sul Cleavage of membrane-associated pref-1 generates a soluble inhibitor of adipocyte differentiation Mol. Cell. Biol. 17 1997 977 988
2. C.M. Smas, D. Green, and H.S. Sul Structural characterization and alternate splicing of the gene encoding the preadipocyte EGF-like protein pref-1 Biochemistry 33 1994 9257 9265
3. C.M. Smas, and H.S. Sul Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation Cell 73 1993 725 734
4. Y.S. Moon, C.M. Smas, K. Lee, J.A. Villena, K.H. Kim, E.J. Yun, and H.S. Sul Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity Mol. Cell. Biol. 22 2002 5585 5592
5. Y. Wang, and H.S. Sul Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation Mol. Cell. Biol. 26 2006 5421 5435
6. Y. Wang, L. Zhao, C. Smas, and H.S. Sul Pref-1 interacts with fibronectin to inhibit adipocyte differentiation Mol. Cell. Biol. 30 2010 3480 3492
7. K.A. Kim, J.H. Kim, Y. Wang, and H.S. Sul Pref-1 (preadipocyte factor 1) activates the MEK/extracellular signal-regulated kinase pathway to inhibit adipocyte differentiation Mol. Cell. Biol. 27 2007 2294 2308
8. C.S. Hudak, O. Gulyaeva, Y. Wang, S.M. Park, L. Lee, C. Kang, and H.S. Sul Pref-1 marks very early mesenchymal precursors required for adipose tissue development and expansion Cell. Rep. 8 2014 678 687
9. K. Lee, J.A. Villena, Y.S. Moon, K.H. Kim, S. Lee, C. Kang, and H.S. Sul Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1) J. Clin. Invest 111 2003 453 461
10. B. Mei, L. Zhao, L. Chen, and H.S. Sul Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing Biochem. J. 364 2002 137 144
11. J.A. Villena, C.S. Choi, Y. Wang, S. Kim, Y.J. Hwang, Y.B. Kim, G. Cline, G.I. Shulman, and H.S. Sul Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy Diabetes 57 2008 3258 3266
12. Y. Wang, and H.S. Sul Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9 Cell. Metab. 9 2009 287 302
13. D. Tornehave, P. Jansen, B. Teisner, H.B. Rasmussen, J. Chemnitz, and G. Moscoso Fetal antigen 1 (FA1) in the human pancreas: cell type expression, topological and quantitative variations during development Anat. Embryol. Berl. 187 1993 335 341
14. D. Tornehave, C.H. Jensen, B. Teisner, and L.I. Larsson FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression Histochem Cell. Biol. 106 1996 535 542
15. B. Peers, J. Leonard, S. Sharma, G. Teitelman, and M.R. Montminy Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1 Mol. Endocrinol. 8 1994 1798 1806
16. M. Peshavaria, L. Gamer, E. Henderson, G. Teitelman, C.V. Wright, and R. Stein XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor Mol. Endocrinol. 8 1994 806 816
17. H. Ohlsson, K. Karlsson, and T. Edlund IPF1, a homeodomain-containing transactivator of the insulin gene EMBO J. 12 1993 4251 4259
18. C. Carlsson, D. Tornehave, K. Lindberg, P. Galante, N. Billestrup, B. Michelsen, L.I. Larsson, and J.H. Nielsen Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas Endocrinology 138 1997 3940 3948
19. J.V. Schmidt, P.G. Matteson, B.K. Jones, X.J. Guan, and S.M. Tilghman The Dlk1 and Gtl2 genes are linked and reciprocally imprinted Genes. Dev. 14 2000 1997 2002
20. S. Takada, M. Tevendale, J. Baker, P. Georgiades, E. Campbell, T. Freeman, M.H. Johnson, M. Paulsen, and A.C. Ferguson-Smith Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12 Curr. Biol. 10 2000 1135 1138
21. M. Kaneta, M. Osawa, K. Sudo, H. Nakauchi, A.G. Farr, and Y. Takahama A role for pref-1 and HES-1 in thymocyte development J. Immunol. 164 2000 256 264