A fatal poisoning involving 25C-NBOMe

Forensic Science International

Volumn 251, Issue , 2015, Pages e1-e8

  Andreasen, Mette Findal ^a   Telving, Rasmus ^a   Rosendal, Ingrid ^a   Eg, Marlene Beyer ^a   Hasselstrøm, Jørgen Bo ^a   Andersen, Ljubica Vukelic ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

25C NBOMe; Intoxication; LC MS MS; Multiple organ failure; UPLC TOFMS

Indexed keywords

2-(4-CHLORO-2,5-DIMETHOXYPHENYL)-N-((2-METHOXYPHENYL)METHYL)ETHANAMINE; BENZYLAMINE DERIVATIVE; PHENETHYLAMINE DERIVATIVE; PSYCHEDELIC AGENT;

CASE REPORT; CHEMISTRY; DRUG OVERDOSE; FORENSIC TOXICOLOGY; HUMAN; INHALANT ABUSE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; STOMACH JUICE; VITREOUS BODY; YOUNG ADULT;

BENZYLAMINES; CHROMATOGRAPHY, LIQUID; DRUG OVERDOSE; FORENSIC TOXICOLOGY; GASTROINTESTINAL CONTENTS; HALLUCINOGENS; HUMANS; INHALANT ABUSE; MALE; MASS SPECTROMETRY; PHENETHYLAMINES; VITREOUS BODY; YOUNG ADULT;

EID: 84937762440     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2015.03.012     Document Type: Article

References (36)

1. EMCDDA European Drug Report, Trends and Developments 2014, EMCDDA.
2. Brandt S.D., King L.A., Evans-Brown.M. The new drug phenomenon. Drug Test Anal. 2014, 6:587-597.
3. Ninnemann A., Stuart G.L. The NBOMe series: a novel, dangerous group of hallucinogenic drugs. J. Stud. Alcohol Drugs 2013, 74:977-978.
4. Lawn W., Barratt M., Williams M., Horne A., Winstock A. The NBOMe hallucinogenic drug series: patterns of use, characteristics of users and self-reported effects in a large international sample. J. Psychopharmacol. 2014, 28:780-788.
5. Caldicott D.G.E., Bright S.J., Barratt M.J. NBOMe-a very different kettle of fish. Med. J. Aust. 2013, 199:322-323.
6. Hill S.L., Doris T., Gurung S., Katebe S., Lomas A., Dunn M., Blain P., Thomas S.H.L. Severe clinical toxicity associated with analytically confirmed recreational use of 25I-NBOMe: case series. Clin. Toxicol. 2013, 51:487-492.
7. Grautoff S., Kähler J. Near fatal intoxication with the novel psychoactive substance 25C-NBOMe. Med. Klin-Intensivmed. 2014, 109:271-275.
8. Nikolaou P., Papoutsis I., Stefanidou M., Spiliopoulou C., Athanaselis S. 2C-I-NBOMe, an N-bomb that kills with Smiles. Toxicological and legislative aspects. Drug Chem. Toxicol. 2015, 38:113-119.
9. Poklis J.L., Devers K.G., Arbefeville E.F., Pearson J.M., Houston E., Poklis A. Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death. Forensic Sci. Int. 2014, 234:e14-e20.
10. Poklis J.L., Nanco C.R., Troendle M.M., Wolf C.E., Poklis A. Determination of 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe) in serum and urine by high performance liquid chromatography with tandem mass spectrometry in a case of severe intoxication. Drug Test Anal. 2014, 6:764-769.
11. Drug Enforcement Administration, Department of Justice, US Schedules of controlled substances: temporary placement of three synthetic phenethylamines into Schedule I. Fed. Regist. 2013, 78(221):68716-68719.
12. Braden M.R., Parrish J.C., Naylor J.C., Nichols D.E. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Mol. Pharmacol. 2006, 70:1956-1964.
13. Braden M.R. Towards a Biophysical Understanding of Hallucinogens Action 2006, Purdue University, West Lafayette, Indiana, (Ph.D. Thesis).
14. Ettrup A., Hansen M., Santini M.A., Paine J., Gillings N., Palner M., Lehel S., Herth M.M., Madsen J., Kristensen J., Begtrup M., Knudsen G.M. Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers. Eur. J. Nucl. Med. Mol. Imaging 2011, 38:681-693.
15. 2A/2C agonists. ACS Chem. Neurosci. 2014, 5:243-249.
16. Zuba D., Sekula K. Analytical characterization of three hallucinogenic N-(2-methoxy)benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Test Anal. 2013, 5:634-645.
17. Poklis J.L., Clay D.J., Poklis A. High-performance liquid chromatography with tandem mass spectrometry for the determination of nine hallucinogenic 25-NBOMe designer drugs in urine specimens. J Anal Toxicol. 2014, 38:113-121.
18. Casale H.P.J.F. Characterization of eleven 2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (NBOMe) derivatives and differentiation from their 3- and 4-methoxybenzyl analogues-Part I. Microgram J. 2012, 9:84-109.
19. Zuba D., Sekula K., Buczek A. 25C-NBOMe-new potent hallucinogenic substance identified on the drug market. Forensic Sci. Int. 2013, 227:7-14.
20. https://www.erowid.org/chemicals/2cc_nbome/2cc_nbome.shtml.
21. Kelly A., Eisenga B., Riley B., Judge B. Case series of 25I-NBOMe exposures with laboratory confirmation. Clin. Toxicol. 2012, 50:702.
22. Rose S.R., Poklis J.L., Poklis A. A case of 25I-NBOMe (25-I) intoxication: a new potent 5-HT2A agonist designer drug. Clin. Toxicol. (Phila) 2013, 51:174-177.
23. Stellpflug S.J., Kealey S.E., Hegarty C.B., Janis G.C. 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe): clinical case with unique confirmatory testing. J. Med. Toxicol. 2014, 10:45-50.
24. Walterscheid J.P., Phillips G.T., Lopez A.E., Gonsoulin M.L., Chen H.H., Sanchez L.A. Pathological findings in 2 cases of fatal 25I-NBOMe toxicity. Am. J. Forensic Med. Pathol. 2014, 35:20-25.
25. Poklis J.L., Charles J., Wolf C.E., Poklis A. High-performance liquid chromatography tandem mass spectrometry method for the determination of 2CC-NBOMe and 25I-NBOMe in human serum. Biomed. Chromatogr. 2013, 27:1794-1800.
26. Soh Y.N., Elliott S. An investigation of the stability of emerging new psychoactive substances. Drug Test Anal. 2014, 6:696-704.
27. World Health Organisation 25C-NBOMe-Critical Review Report 2014, World Health Organisation. 36th ECDD.
28. Tang M.H.Y., Ching C.K., Tsui M.S.H., Chu F.K.C., Mak T.W.L. Two cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMe. Clin. Toxicol. 2014, 52:561-565.
29. Armenian P., Gerona R.R. The electric Kool-Aid NBOMe test: LC-TOF/MS confirmed 2C-C-NBOMe (25C) intoxication at Burning Man. Am. J. Emerg. Med. 2014, 32:1444.e1443-1444.e1445.
30. Sørensen L.K. Determination of acidic and neutral therapeutic drugs in human blood by liquid chromatography-electrospray tandem mass spectrometry. Forensic Sci. Int. 2011, 206:119-226.
31. Sørensen L.K., Hasselstrom J.B. A high-throughput multi-class liquid chromatography tandem mass spectrometry method for quantitative determination of licit and illicit drugs in whole blood. Anal. Methods 2013, 5:3185-3193.
32. Kronstrand R., Nystrom I., Andersson M., Gunnarsson L., Hagg S., Josefsson M., Ahlner J. Urinary detection times and metabolite/parent compound ratios after a single dose of buprenorphine. J. Anal. Toxicol. 2008, 32:586-593.
33. DIN 32633 Chemical Analysis - Methods of Standard Addition - Procedure, Evaluation Standard by Deutsches Institut Fur Normung E.V. (German National Standard), 12/01/1998, 1-7.
34. Peters F.T., Drummer O.H., Musshoff F. Validation of new methods. Forensic Sci. Int. 2007, 165:216-224.
35. Jones A.W., Holmgren A. Amphetamine abuse in Swed subject demographics changes in blood concentrations over time the types of coingested substances. J. Clin. Psychopharmacol. 2013, 33:248-252.
36. Stork C.M. Serotonin reuptake inhibitors and atypical antidepressants. Goldfrank's Toxicologic Emergencies 9 2011, 1041-1043. The Mc Graw Hill Companies, New York. L.S. Nelson, N.A. Lewin, M.A. Howland, R.S. Hoffman, L.R. Goldfrank, N.E. Flomenbaum (Eds.).