2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe): Clinical Case with Unique Confirmatory Testing

Journal of Medical Toxicology

Volumn 10, Issue 1, 2014, Pages 45-50

  Stellpflug, Samuel J ^a   Kealey, Samantha E ^a   Hegarty, Cullen B ^a   Janis, Gregory C ^b  

^a REGIONS HOSPITAL   (United States)

^b MEDTOX Laboratories   (United States)

Author keywords

25 I; 25i; Hallucinogen; Phenethylamine; Shulgin

Indexed keywords

2 (4 IODO 2 5 DIMETHOXYPHENYL) N [(2 METHOXYPHENYL)METHYL]ETHANAMINE; 25H NBOME; BENZODIAZEPINE; INFUSION FLUID; LORAZEPAM; PHENETHYLAMINE DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; 2-(4-BROMO-2,5-DIMETHOXYPHENYL)ETHYLAMINE; 2-(4-IODO-2,5-DIMETHOXYPHENYL)-N-(2-METHOXYBENZYL)ETHANAMINE; 4-IODO-2,5-DIMETHOXY-BETA-PHENETHYLAMINE; BIOLOGICAL MARKER; DESIGNER DRUG; HOMOVERATRYLAMINE; PSYCHEDELIC AGENT;

ADULT; AGITATION; ANXIETY; ARTICLE; CASE REPORT; CONFUSION; DRUG INTOXICATION; FEMALE; FLUSHING; HUMAN; HYPERREFLEXIA; HYPERTENSION; LIQUID CHROMATOGRAPHY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; QUALITY CONTROL PROCEDURES; SELECTIVITY; SPECIFICITY; TACHYCARDIA; TIME OF FLIGHT MASS SPECTROMETRY; TONIC CLONIC SEIZURE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; YOUNG ADULT; ADOLESCENT; ANALOGS AND DERIVATIVES; BIOTRANSFORMATION; EPILEPSY, TONIC-CLONIC; NEUROTOXICITY SYNDROMES; PATHOPHYSIOLOGY; SUBSTANCE ABUSE; TOXICITY; TREATMENT OUTCOME; UNITED STATES; URINE;

ADOLESCENT; BIOLOGICAL MARKERS; BIOTRANSFORMATION; DESIGNER DRUGS; DIMETHOXYPHENYLETHYLAMINE; EPILEPSY, TONIC-CLONIC; FEMALE; HALLUCINOGENS; HUMANS; MINNESOTA; NEUROTOXICITY SYNDROMES; SUBSTANCE ABUSE DETECTION; TREATMENT OUTCOME;

EID: 84897580824     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-013-0314-y     Document Type: Article

References (17)

1. Rosenbaum CD, Carreiro SP, Babu KM (2012) Here today, gone tomorrow.and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. J Med Toxicol 8: 15-32.
2. Shulgin AT, Shulgin A (1991) PIHKAL: a chemical love story. Transform, Berkeley.
3. Dean BV, Stellpflug SJ, Burnett AB, Engebretsen KM (2013) 2C or not 2C: phenethylamine designer drug review. J Med Toxicol 9: 172-178.
4. Rupar A (2012) Adam Budge, 18, charged with murder following friend's synthetic drug overdose. Minneapolis: City Pages [updated 21 Jun 2012]. http://blogs. citypages. com/blotter/2012/06/adam_budge_18_charged_with_murder_following_friends_synthetic_drug_overdose. php. Accessed 16 Feb 2013.
5. Walsh P (2012) U. S. indicts four in synthetic drug deaths. Minneapolis: Star Tribune [updated 27 Dec 2012]. http://www. startribune. com/printarticle/?id=184934801. Accessed 16 Feb 2013.
6. Erowid. com (2012) 25I-NBOMe (2C-I-NBOMe) fatalities/deaths [updated 12 Sep 2012]. http://www. erowid. org/chemicals/2ci_nbome/2ci_nbome_death. shtml. Accessed 16 Feb 2013.
7. U. S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM) (2001) Guide for industry: Bioanalytical validation. http://www. fda. gov/downloads/Drugs/Guidances/ucm070107. pdf. Accessed 16 Feb 2013.
8. Scientific Working Group for Forensic Toxicology (SWGTOX) (2012) Standard practices for method validation in forensic toxicology. http://www. swgtox. org/documents/Validation_public_comment. pdf. Accessed 16 Feb 2013.
9. Drug Enforcement Administration (2011) 4-Bromo-2, 5-dimethoxyphenethylamine information sheet. Washington, DC: Drug Enforcement Administration [updated 16 Feb 2011]. http://www. deadiversion. usdoj. gov/drugs_concern/bromo_dmp/bromo_dmp. pdf. Accessed 12 Feb 2013.
10. 112th Congress (2012) S. 3187: Food and Drug Administration Safety and Innovation Act. Section 1152. Washington, DC: Library of Congress [updated 10 Jul 2012]. http://beta. congress. gov/bill/112th-congress/senate-bill/3187. Accessed 12 Feb 2013.
11. Nichols DE (2004) Hallucinogens. Pharmacol Ther 101: 131-181.
12. Nichols DE, Frescas SP, Chemel BR, Rehder KS, Zhong D, Lewin AH (2008) High specific activity tritium-labeled N-(2-methoxybenzyl)-2, 5-dimethoxy-4-iodophenethylamine (INBMeO): a high affinity 5-HT2A receptor-selective agonist radioligand. Bioorg Med Chem 16: 6116-6123.
13. 2A and group II metabotropic glutamate receptors in prefrontal cortex. J Pharmacol Exp Ther 292: 76-87.
14. (6. 52) with superpotent N-benzyl phenethylamine agonists. Mol Pharmacol 70: 1956-1964.
15. Kelly A, Eisenga B, Riley B, Judge B (2012) Case series of 25I-NBOMe exposures with laboratory confirmation. Clin Toxicol 50: 70.
16. Rose SR, Cumpston KL, Stromberg PE, Wills BK (2012) Severe poisoning following self-reported use of 25-I, a novel substituted amphetamine. Clin Toxicol 50: 70.
17. Rose SR, Poklis JL, Poklis A (2013) A case of 25I-NBOMe (25-I) intoxication: a new potent 5-HT2A agonist designer drug. Clin Toxicol 51(3): 174-177.