Intensified autophagy compromises the efficacy of radiotherapy against prostate cancer

Biochemical and Biophysical Research Communications

Volumn 461, Issue 2, 2015, Pages 268-274

  Koukourakis, Michael I ^a   Kalamida, Dimitra ^a   Mitrakas, Achilleas ^a   Pouliliou, Stamatia ^a   Kalamida, Sofia ^a   Sivridis, Efthimios ^a   Giatromanolaki, Alexandra ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Aggresomes; Autophagy; LAMP2a; LC3A; Prostate cancer; Radiotherapy

Indexed keywords

LAMP2 PROTEIN, HUMAN; LIGHT CHAIN 3, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN;

AGED; AUTOPHAGY; HUMAN; MALE; MIDDLE AGED; PATHOLOGY; PROSTATE; PROSTATIC NEOPLASMS; RADIATION RESPONSE; TUMOR CELL LINE; TUMOR RECURRENCE;

AGED; AUTOPHAGY; CELL LINE, TUMOR; HUMANS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROSTATE; PROSTATIC NEOPLASMS;

EID: 84937760284     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.04.014     Document Type: Article

References (22)

1. P.A. Kupelian, M. Elshaikh, V.A. Reddy, et al. Comparison of the efficacy of local therapies for localized prostate cancer in the prostate-specific antigen era: a large single-institution experience with radical prostatectomy and external-beam radiotherapy J. Clin. Oncol. 20 2002 3376 3385
2. A. Baccala Jr., A.M. Reuther, F.J. Bianco Jr., et al. Complete resection of seminal vesicles at radical prostatectomy results in substantial long-term disease-free survival: multi-institutional study of 6740 patients Urology 69 2007 536 540
3. R.M. Galalae, G. Kovács, J. Schultze, et al. Long-term outcome after elective irradiation of the pelvic lymphatics and local dose escalation using high-dose-rate brachytherapy for locally advanced prostate cancer Int. J. Radiat. Oncol. Biol. Phys. 52 2002 81 90
4. S.E. Berry, and T.J. Kinsella Targeting DNA mismatch repair for radiosensitization Semin. Radiat. Oncol. 11 2001 300 315
5. D.J. Klionsky, F.C. Abdalla, H. Abeliovich, et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy 8 2012 445 544
6. C.E. Zois, and M.I. Koukourakis Radiation-induced autophagy in normal and cancer cells: towards novel cytoprotection and radio-sensitization policies? Autophagy 5 2009 442 450
7. A.M. Cuervo, and J.F. Dice Regulation of lamp2a levels in the lysosomal membrane Traffic 1 2000 570 583
8. M.I. Koukourakis, A. Papadopoulou, I. Abatzoglou, et al. Postoperative pelvic hypofractionated accelerated radiotherapy with cytoprotection (HypoARC) for high-risk or recurrent prostate cancer Anticancer Res. 32 2012 4561 4568
9. M.A. Zachari, P.S. Chondrou, S.E. Pouliliou, et al. Evaluation of the alamarblue assay for adherent cell irradiation experiments Dose Response 12 2013 246 258
10. A. Giatromanolaki, E. Sivridis, A. Mitrakas, et al. Autophagy and lysosomal related protein expression patterns in human glioblastoma Cancer Biol. Ther. 15 2014 1468 1478
11. E. Sivridis, A. Giatromanolaki, V. Liberis, et al. Autophagy in endometrial carcinomas and prognostic relevance of 'stone-like' structures (SLS): what is destined for the atypical endometrial hyperplasia? Autophagy 7 2011 74 82
12. E. Sivridis, M.I. Koukourakis, C.E. Zois, et al. LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas Am. J. Pathol. 176 2010 2477 2489
13. A. Giatromanolaki, E. Sivridis, S. Mendrinos, et al. Autophagy proteins in prostate cancer: relation with anaerobic metabolism and Gleason score Urol. Oncol. 32 2014 39.e11-8
14. A. Guidetti, C. Carlo-Stella, S.L. Locatelli, et al. Phase II study of sorafenib in patients with relapsed or refractory lymphoma Br. J. Haematol. 158 2012 108 119
15. X.H. Ma, S. Piao, D. Wang, et al. Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma Clin. Cancer. Res. 17 2011 3478 3489
16. G.F. Guo, W.Q. Jiang, B. Zhang, et al. Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer World J. Gastroenterol. 17 2011 4779 4786
17. M.I. Koukourakis, A. Giatromanolaki, A. Bottini, et al. Prospective neoadjuvant analysis of PET imaging and mechanisms of resistance to Trastuzumab shows role of HIF1 and autophagy Br. J. Cancer 110 2014 2209 2216
18. Y. Chen, X. Li, X. Wu, et al. Autophagy-related proteins LC3 and Beclin-1 impact the efficacy of chemoradiation on esophageal squamous cell carcinoma Pathol. Res. Pract. 209 2013 562 567
19. X.B. Wan, X.J. Fan, M.Y. Chen, et al. Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma Autophagy 6 2010 395 404
20. D. Kalamida, I.V. Karagounis, A. Giatromanolaki, et al. Important role of autophagy in endothelial cell response to ionizing radiation PLoS One 9 2014 e102408
21. L. Chang, P.H. Graham, J. Hao, et al. PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways Cell Death Dis. 5 2014 e1437
22. M. Pennati, A. Lopergolo, V. Profumo, et al. miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells Biochem. Pharmacol. 87 2014 579 597