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Volumn 29, Issue 2, 2015, Pages 143-150

Olaparib: A review of its use as maintenance therapy in patients with ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; OLAPARIB; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE;

EID: 84937759671     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.1007/s40259-015-0125-6     Document Type: Article
Times cited : (35)

References (36)
  • 1
    • 84937764769 scopus 로고    scopus 로고
    • Cancer Research UK Accessed 11 Dec 2014
    • Cancer Research UK. Cancer mortality for common cancers. 2011. http://www.cancerresearchuk.org. Accessed 11 Dec 2014.
    • (2011) Cancer Mortality for Common Cancers
  • 3
    • 84866749053 scopus 로고    scopus 로고
    • Optimal first-line treatment in ovarian cancer
    • 22987945
    • Raja FA, Chopra N, Ledermann JA. Optimal first-line treatment in ovarian cancer. Ann Oncol. 2012;23(Suppl 10):x118-27.
    • (2012) Ann Oncol. , vol.23 , pp. 118-x127
    • Raja, F.A.1    Chopra, N.2    Ledermann, J.A.3
  • 4
    • 84937771402 scopus 로고    scopus 로고
    • Lynparza. International non-proprietary name: Olaparib
    • European Medicines Agency Accessed 4 Mar 2015
    • European Medicines Agency. Lynparza. International non-proprietary name: Olaparib. European public assessment report. 2014. http://www.ema.europa.eu. Accessed 4 Mar 2015.
    • (2014) European Public Assessment Report
  • 5
    • 84885334240 scopus 로고    scopus 로고
    • Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • vi24-32.
    • Ledermann JA, Raja FA, Fotopoulou C, et al. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24(Suppl 6):vi24-32.
    • (2013) Ann Oncol , vol.24 , Issue.6
    • Ledermann, J.A.1    Raja, F.A.2    Fotopoulou, C.3
  • 6
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474:609-15.
    • (2011) Nature. , vol.474 , pp. 609-615
  • 7
    • 84901049026 scopus 로고    scopus 로고
    • Reversing platinum resistance in high-grade serous ovarian carcinoma: Targeting BRCA and the homologous recombination system
    • 10.3389/fonc.2014.00034 3939430 24624361
    • Wiedemeyer WR, Beach JA, Karlan BY. Reversing platinum resistance in high-grade serous ovarian carcinoma: targeting BRCA and the homologous recombination system. Front Oncol. 2014;4:34. doi: 10.3389/fonc.2014.00034.
    • (2014) Front Oncol. , vol.4 , pp. 34
    • Wiedemeyer, W.R.1    Beach, J.A.2    Karlan, B.Y.3
  • 8
    • 84903547236 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial
    • 1:CAS:528:DC%2BC2cXhtVWrsrrK 24882434
    • Ledermann J, Harter P, Gourley C, et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol. 2014;15(8):852-61.
    • (2014) Lancet Oncol. , vol.15 , Issue.8 , pp. 852-861
    • Ledermann, J.1    Harter, P.2    Gourley, C.3
  • 9
    • 84906099838 scopus 로고    scopus 로고
    • Maintenance therapy in ovarian cancer
    • 1:CAS:528:DC%2BC2cXhtlans7rF 25033374
    • Khalique S, Hook JM, Ledermann JA. Maintenance therapy in ovarian cancer. Curr Opin Oncol. 2014;26(5):521-8.
    • (2014) Curr Opin Oncol. , vol.26 , Issue.5 , pp. 521-528
    • Khalique, S.1    Hook, J.M.2    Ledermann, J.A.3
  • 10
    • 84877902627 scopus 로고    scopus 로고
    • Bevacizumab and ovarian cancer
    • 3556875 1:CAS:528:DC%2BC2MXjsVert7c%3D 23450196
    • Garcia A, Singh H. Bevacizumab and ovarian cancer. Ther Adv Med Oncol. 2013;5(2):133-41.
    • (2013) Ther Adv Med Oncol. , vol.5 , Issue.2 , pp. 133-141
    • Garcia, A.1    Singh, H.2
  • 11
    • 84880811116 scopus 로고    scopus 로고
    • Olaparib: A promising PARP inhibitor in ovarian cancer therapy
    • 1:CAS:528:DC%2BC3sXhtFWjsbvK 23619942
    • Chen Y, Zhang L, Hao Q. Olaparib: a promising PARP inhibitor in ovarian cancer therapy. Arch Gynecol Obstet. 2013;288(2):367-74.
    • (2013) Arch Gynecol Obstet. , vol.288 , Issue.2 , pp. 367-374
    • Chen, Y.1    Zhang, L.2    Hao, Q.3
  • 12
    • 84884125515 scopus 로고    scopus 로고
    • Emerging treatment options for recurrent ovarian cancer: The potential role of olaparib
    • 3772750 24043945
    • Shaw HM, Hall M. Emerging treatment options for recurrent ovarian cancer: the potential role of olaparib. Onco Targets Ther. 2013;6:1197-206.
    • (2013) Onco Targets Ther. , vol.6 , pp. 1197-1206
    • Shaw, H.M.1    Hall, M.2
  • 13
    • 84899076408 scopus 로고    scopus 로고
    • Olaparib for the treatment of ovarian cancer
    • 1:CAS:528:DC%2BC2cXntVensLc%3D
    • Lheureux S, Oza AM. Olaparib for the treatment of ovarian cancer. Expert Opin Orphan Drugs. 2014;2(5):497-508.
    • (2014) Expert Opin Orphan Drugs. , vol.2 , Issue.5 , pp. 497-508
    • Lheureux, S.1    Oza, A.M.2
  • 14
    • 84864687912 scopus 로고    scopus 로고
    • PARP inhibitors: Mechanism of action and their potential role in the prevention and treatment of cancer
    • 1:CAS:528:DC%2BC38XhsVCju7bE 22834679
    • Basu B, Sandhu SK, de Bono JS. PARP inhibitors: mechanism of action and their potential role in the prevention and treatment of cancer. Drugs. 2012;72(12):1579-90.
    • (2012) Drugs. , vol.72 , Issue.12 , pp. 1579-1590
    • Basu, B.1    Sandhu, S.K.2    De Bono, J.S.3
  • 15
    • 84889575620 scopus 로고    scopus 로고
    • The elephant and the blind men: Making sense of PARP inhibitors in homologous recombination deficient tumor cells
    • 10.3389/fonc.2013.00228 3769628 24062981
    • De Lorenzo SB, Patel AG, Hurley RM, et al. The elephant and the blind men: making sense of PARP inhibitors in homologous recombination deficient tumor cells. Front Oncol. 2013;3:228. doi: 10.3389/fonc.2013.00228.
    • (2013) Front Oncol. , vol.3 , pp. 228
    • De Lorenzo, S.B.1    Patel, A.G.2    Hurley, R.M.3
  • 16
    • 84897012760 scopus 로고    scopus 로고
    • PARP inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
    • 3868320 24225019
    • Lee JM, Ledermann JA, Kohn EC. PARP inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol. 2014;25(1):32-40.
    • (2014) Ann Oncol. , vol.25 , Issue.1 , pp. 32-40
    • Lee, J.M.1    Ledermann, J.A.2    Kohn, E.C.3
  • 17
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • 1:CAS:528:DC%2BD1cXhtVGjs7rL 18591545
    • Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol. 2008;26(22):3785-90.
    • (2008) J Clin Oncol. , vol.26 , Issue.22 , pp. 3785-3790
    • Ashworth, A.1
  • 18
    • 84887431012 scopus 로고    scopus 로고
    • Mechanisms of resistance to therapies targeting BRCA-mutant cancers
    • 1:CAS:528:DC%2BC3sXhslCnu73O 24202391
    • Lord CJ, Ashworth A. Mechanisms of resistance to therapies targeting BRCA-mutant cancers. Nat Med. 2013;19:1381-8.
    • (2013) Nat Med. , vol.19 , pp. 1381-1388
    • Lord, C.J.1    Ashworth, A.2
  • 19
    • 39549091276 scopus 로고    scopus 로고
    • Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
    • 10.1186/1471-2407-8-17 2245962 18208621
    • Press JZ, De Luca A, Boyd N, et al. Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities. BMC Cancer. 2008;8:17. doi: 10.1186/1471-2407-8-17.
    • (2008) BMC Cancer. , vol.8 , pp. 17
    • Press, J.Z.1    De Luca, A.2    Boyd, N.3
  • 20
    • 84864026311 scopus 로고    scopus 로고
    • BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian Ovarian Cancer Study Group
    • 3413277 1:CAS:528:DC%2BC38Xht1ygsr%2FN 22711857
    • Alsop K, Fereday S, Meldrum C, et al. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. J Clin Oncol. 2012;30:2654-63.
    • (2012) J Clin Oncol. , vol.30 , pp. 2654-2663
    • Alsop, K.1    Fereday, S.2    Meldrum, C.3
  • 22
    • 84857383257 scopus 로고    scopus 로고
    • Update on PARP1 inhibitors in ovarian cancer
    • viii72-6
    • Sessa C. Update on PARP1 inhibitors in ovarian cancer. Ann Oncol. 2011;22(Suppl 8):viii72-6.
    • (2011) Ann Oncol , vol.22 , Issue.8
    • Sessa, C.1
  • 23
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • 1:CAS:528:DC%2BD1MXosVKrtrw%3D 19553641
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361(2):123-34.
    • (2009) N Engl J Med. , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 24
    • 79951819983 scopus 로고    scopus 로고
    • Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts
    • 1:CAS:528:DC%2BC3MXitVSqu7s%3D 21097693
    • Kortmann U, McAlpine JN, Xue H, et al. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts. Clin Cancer Res. 2011;17(4):783-91.
    • (2011) Clin Cancer Res. , vol.17 , Issue.4 , pp. 783-791
    • Kortmann, U.1    McAlpine, J.N.2    Xue, H.3
  • 25
    • 84901236439 scopus 로고    scopus 로고
    • Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells
    • 4058036 24798692
    • Choi YE, Battelli C, Watson J, et al. Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. Oncotarget. 2014;5(9):2678-87.
    • (2014) Oncotarget. , vol.5 , Issue.9 , pp. 2678-2687
    • Choi, Y.E.1    Battelli, C.2    Watson, J.3
  • 26
    • 84901684118 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer
    • 1:CAS:528:DC%2BC2cXkvFShsr8%3D 24631446
    • Konstantinopoulos PA, Wilson AJ, Saskowski J, et al. Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer. Gynecol Oncol. 2014;133(3):599-606.
    • (2014) Gynecol Oncol. , vol.133 , Issue.3 , pp. 599-606
    • Konstantinopoulos, P.A.1    Wilson, A.J.2    Saskowski, J.3
  • 27
    • 84921771510 scopus 로고    scopus 로고
    • Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation
    • 25366685
    • Kaufman B, Shapira-Frommer R, Schmutzler RK, et al. Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol. 2014;33(3):244-50.
    • (2014) J Clin Oncol. , vol.33 , Issue.3 , pp. 244-250
    • Kaufman, B.1    Shapira-Frommer, R.2    Schmutzler, R.K.3
  • 28
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • 1:CAS:528:DC%2BC3cXpt1Kktb4%3D 20609468
    • Audeh MW, Carmichael J, Penson RT, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet. 2010;376(9737):245-51.
    • (2010) Lancet. , vol.376 , Issue.9737 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3
  • 29
    • 84863010984 scopus 로고    scopus 로고
    • Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer
    • 1:CAS:528:DC%2BC38XktVKgsr8%3D 22203755
    • Kaye SB, Lubinski J, Matulonis U, et al. Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J Clin Oncol. 2012;30(4):372-9.
    • (2012) J Clin Oncol. , vol.30 , Issue.4 , pp. 372-379
    • Kaye, S.B.1    Lubinski, J.2    Matulonis, U.3
  • 30
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • 1:CAS:528:DC%2BC3MXhtFSqs7%2FE 21862407
    • Gelmon KA, Tischkowitz M, Mackay H, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol. 2011;12(9):852-61.
    • (2011) Lancet Oncol. , vol.12 , Issue.9 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3
  • 31
    • 84859523588 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
    • 1:CAS:528:DC%2BC38XlslOrsLw%3D 22452356
    • Ledermann J, Harter P, Gourley C, et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med. 2012;366(15):1382-92.
    • (2012) N Engl J Med. , vol.366 , Issue.15 , pp. 1382-1392
    • Ledermann, J.1    Harter, P.2    Gourley, C.3
  • 33
    • 84961978950 scopus 로고    scopus 로고
    • A phase i study to determine the comparative bioavailability of two different oral formulations of the PARP inhibitor, olaparib (AZD2281), in patients with advanced solid tumors (abstract no. 2599)
    • Molife LR, Forster MD, Krebs M, et al. A phase I study to determine the comparative bioavailability of two different oral formulations of the PARP inhibitor, olaparib (AZD2281), in patients with advanced solid tumors (abstract no. 2599). J Clin Oncol. 2010;28(15 Suppl).
    • (2010) J Clin Oncol , vol.28 , Issue.15
    • Molife, L.R.1    Forster, M.D.2    Krebs, M.3
  • 34
    • 84978437276 scopus 로고    scopus 로고
    • Safety and efficacy results from two randomized expansions of a phase i study of a tablet formulation of the PARP inhibitor, olaparib, in ovarian and breast cancer patients with BRCA1/2 mutations (abstract no. 3048)
    • Molife LR, Mateo J, McGoldrick T, et al. Safety and efficacy results from two randomized expansions of a phase I study of a tablet formulation of the PARP inhibitor, olaparib, in ovarian and breast cancer patients with BRCA1/2 mutations (abstract no. 3048). J Clin Oncol. 2012;30(Suppl).
    • (2012) J Clin Oncol , vol.30
    • Molife, L.R.1    Mateo, J.2    McGoldrick, T.3
  • 35
    • 84906092305 scopus 로고    scopus 로고
    • Administration of continuous/intermittent olaparib in ovarian cancer patients with a germline BRCA1/2 mutation to determine an optimal dosing schedule for the tablet formulation (abstract no. 801)
    • Mateo J, Friedlander M, Sessa C, et al. Administration of continuous/intermittent olaparib in ovarian cancer patients with a germline BRCA1/2 mutation to determine an optimal dosing schedule for the tablet formulation (abstract no. 801). Eur J Cancer. 2013;49:S161.
    • (2013) Eur J Cancer. , vol.49 , pp. 161
    • Mateo, J.1    Friedlander, M.2    Sessa, C.3
  • 36
    • 84925489080 scopus 로고    scopus 로고
    • SOLO1 and SOLO2: Randomized phase III trials of olaparib in patients (pts) with ovarian cancer and a BRCA1/2 mutation (BRCAm) (abstract no. TPS5616)
    • Moore KN, Di Silvestro P, Lowe ES, et al. SOLO1 and SOLO2: randomized phase III trials of olaparib in patients (pts) with ovarian cancer and a BRCA1/2 mutation (BRCAm) (abstract no. TPS5616). J Clin Oncol. 2014;32(5 Suppl).
    • (2014) J Clin Oncol. , vol.32 , Issue.5
    • Moore, K.N.1    Di Silvestro, P.2    Lowe, E.S.3


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