메뉴 건너뛰기




Volumn 7, Issue 6, 2015, Pages 611-619

Talimogene laherparepvec (T-VEC) for the treatment of advanced melanoma

Author keywords

GM CSF; HSV; immune therapy; injectable; melanoma; oncolytic; T VEC; talimogene laherperepvec

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; IPILIMUMAB; PEMBROLIZUMAB; TALIMOGENE LAHERPAREPVEC; VELIMOGENE ALIPLASMID; ONCOLYTIC VIRUS;

EID: 84937693906     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.15.35     Document Type: Article
Times cited : (137)

References (50)
  • 2
    • 39149104690 scopus 로고    scopus 로고
    • Meta-analysis of Phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future Phase II trials
    • Korn EL, Liu PY, Lee SJ et al. Meta-analysis of Phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future Phase II trials. J. Clin. Oncol. 26, 527-534 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 527-534
    • Korn, E.L.1    Liu, P.Y.2    Lee, S.J.3
  • 3
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • Balch CM, Gershenwald JE, Soong SJ et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol. 27, 6199-6206 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 4
    • 84921935903 scopus 로고    scopus 로고
    • In-transit melanoma metastases: Incidence, prognosis, and the role of lymphadenectomy
    • Read RL, Haydu L, Saw RP et al. In-transit melanoma metastases: incidence, prognosis, and the role of lymphadenectomy. Ann. Surg. Oncol. 22, 475-481 (2015).
    • (2015) Ann. Surg. Oncol. , vol.22 , pp. 475-481
    • Read, R.L.1    Haydu, L.2    Saw, R.P.3
  • 5
    • 0032926896 scopus 로고    scopus 로고
    • Relation between limb toxicity and treatment outcomes after isolated limb perfusion for recurrent melanoma
    • Vrouenraets BC, Hart GA, Eggermont AM et al. Relation between limb toxicity and treatment outcomes after isolated limb perfusion for recurrent melanoma. J. Am. Coll. Surg. 188, 522-530 (1999).
    • (1999) J. Am. Coll. Surg. , vol.188 , pp. 522-530
    • Vrouenraets, B.C.1    Hart, G.A.2    Eggermont, A.M.3
  • 6
    • 0031893171 scopus 로고    scopus 로고
    • Isolated limb infusion with cytotoxic agents: A simple alternative to isolated limb perfusion
    • Thompson JF, Kam PC, Waugh RC et al. Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion. Semin. Surg. Oncol. 14, 238-247 (1998).
    • (1998) Semin. Surg. Oncol. , vol.14 , pp. 238-247
    • Thompson, J.F.1    Kam, P.C.2    Waugh, R.C.3
  • 7
    • 84893967493 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with electrochemotherapy
    • Campana LG, Testori A, Mozzillo N et al. Treatment of metastatic melanoma with electrochemotherapy. J. Surg. Oncol. 109, 301-307 (2014).
    • (2014) J. Surg. Oncol. , vol.109 , pp. 301-307
    • Campana, L.G.1    Testori, A.2    Mozzillo, N.3
  • 9
    • 84920394727 scopus 로고    scopus 로고
    • Improved overall survival in melanoma with combined dabrafenib and trametinib
    • Robert C, Karaszewska B, Schachter J et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N. Engl. J. Med. 372(1), 30-39 (2014).
    • (2014) N. Engl. J. Med. , vol.372 , Issue.1 , pp. 30-39
    • Robert, C.1    Karaszewska, B.2    Schachter, J.3
  • 10
    • 84881512367 scopus 로고    scopus 로고
    • Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin
    • Hodi FS, Corless CL, Giobbie-Hurder A et al. Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. J. Clin. Oncol. 31, 3182-3190 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3182-3190
    • Hodi, F.S.1    Corless, C.L.2    Giobbie-Hurder, A.3
  • 11
    • 84908245075 scopus 로고    scopus 로고
    • Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
    • Larkin J, Ascierto PA, Dreno B et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N. Engl. J. Med. 371, 1867-1876 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1867-1876
    • Larkin, J.1    Ascierto, P.A.2    Dreno, B.3
  • 12
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 13
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 14
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A et al. Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma. N. Engl. J. Med. 369, 134-144 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 15
    • 0016176253 scopus 로고
    • BCG immunotherapy of malignant melanoma: Summary of a seven-year experience
    • Morton DL, Eilber FR, Holmes EC et al. BCG immunotherapy of malignant melanoma: summary of a seven-year experience. Ann. Surg. 180, 635-643 (1974).
    • (1974) Ann. Surg. , vol.180 , pp. 635-643
    • Morton, D.L.1    Eilber, F.R.2    Holmes, E.C.3
  • 16
    • 1842582038 scopus 로고    scopus 로고
    • Mature results of a Phase III randomized trial of bacillus Calmette-Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer Stage I-III melanoma (E1673): A trial of the Eastern Oncology Group
    • Agarwala SS, Neuberg D, Park Y et al. Mature results of a Phase III randomized trial of bacillus Calmette-Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer Stage I-III melanoma (E1673): a trial of the Eastern Oncology Group. Cancer 100, 1692-1698 (2004).
    • (2004) Cancer , vol.100 , pp. 1692-1698
    • Agarwala, S.S.1    Neuberg, D.2    Park, Y.3
  • 17
    • 0029949031 scopus 로고    scopus 로고
    • Clinical responses and lymphoid infiltrates in metastatic melanoma following treatment with intralesional GM-CSF
    • Si Z, Hersey P, Coates AS. Clinical responses and lymphoid infiltrates in metastatic melanoma following treatment with intralesional GM-CSF. Melanoma Res. 6, 247-255 (1996).
    • (1996) Melanoma Res. , vol.6 , pp. 247-255
    • Si, Z.1    Hersey, P.2    Coates, A.S.3
  • 18
    • 0023870584 scopus 로고
    • Intralesional interferon-alpha therapy in advanced malignant melanoma
    • von Wussow P, Block B, Hartmann F et al. Intralesional interferon-alpha therapy in advanced malignant melanoma. Cancer 61, 1071-1074 (1988).
    • (1988) Cancer , vol.61 , pp. 1071-1074
    • Von Wussow, P.1    Block, B.2    Hartmann, F.3
  • 19
    • 41949096891 scopus 로고    scopus 로고
    • Oncolytic virotherapy: Molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses
    • Guo ZS, Thorne SH, Bartlett DL. Oncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses. Biochim. Biophys. Acta 1785, 217-231 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1785 , pp. 217-231
    • Guo, Z.S.1    Thorne, S.H.2    Bartlett, D.L.3
  • 22
    • 84906483079 scopus 로고    scopus 로고
    • Trial watch: Oncolytic viruses for cancer therapy
    • Pol J, Bloy N, Obrist F et al. Trial watch: oncolytic viruses for cancer therapy. Oncoimmunology 3, e28694 (2014).
    • (2014) Oncoimmunology , vol.3 , pp. e28694
    • Pol, J.1    Bloy, N.2    Obrist, F.3
  • 23
    • 84882452568 scopus 로고    scopus 로고
    • A Phase i clinical trial of Ad5/3-Delta24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer
    • Kim KH, Dmitriev IP, Saddekni S et al. A Phase I clinical trial of Ad5/3-Delta24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer. Gynecol. Oncol. 130, 518-524 (2013).
    • (2013) Gynecol. Oncol. , vol.130 , pp. 518-524
    • Kim, K.H.1    Dmitriev, I.P.2    Saddekni, S.3
  • 24
    • 84878074018 scopus 로고    scopus 로고
    • Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus
    • Kanerva A, Nokisalmi P, Diaconu I et al. Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus. Clin. Cancer Res. 19, 2734-2744 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2734-2744
    • Kanerva, A.1    Nokisalmi, P.2    Diaconu, I.3
  • 25
    • 44249100151 scopus 로고    scopus 로고
    • Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: A Phase i trial
    • Park BH, Hwang T, Liu TC et al. Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a Phase I trial. Lancet Oncol. 9, 533-542 (2008).
    • (2008) Lancet Oncol. , vol.9 , pp. 533-542
    • Park, B.H.1    Hwang, T.2    Liu, T.C.3
  • 26
    • 84878530852 scopus 로고    scopus 로고
    • Oncolytic adenovirus with temozolomide induces autophagy and antitumor immune responses in cancer patients
    • Liikanen I, Ahtiainen L, Hirvinen ML et al. Oncolytic adenovirus with temozolomide induces autophagy and antitumor immune responses in cancer patients. Mol. Ther. 21, 1212-1223 (2013).
    • (2013) Mol. Ther. , vol.21 , pp. 1212-1223
    • Liikanen, I.1    Ahtiainen, L.2    Hirvinen, M.L.3
  • 27
    • 84901035359 scopus 로고    scopus 로고
    • Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans
    • Bramante S, Koski A, Kipar A et al. Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans. Int. J. Cancer 135, 720-730 (2014).
    • (2014) Int. J. Cancer , vol.135 , pp. 720-730
    • Bramante, S.1    Koski, A.2    Kipar, A.3
  • 28
    • 0037295403 scopus 로고    scopus 로고
    • ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties
    • Liu BL, Robinson M, Han ZQ et al. ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Ther. 10, 292-303 (2003).
    • (2003) Gene Ther. , vol.10 , pp. 292-303
    • Liu, B.L.1    Robinson, M.2    Han, Z.Q.3
  • 29
    • 0034047619 scopus 로고    scopus 로고
    • Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand
    • Mach N, Gillessen S, Wilson SB et al. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 60, 3239-3246 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3239-3246
    • Mach, N.1    Gillessen, S.2    Wilson, S.B.3
  • 30
    • 84919468025 scopus 로고    scopus 로고
    • Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity
    • Broz ML, Binnewies M, Boldajipour B et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell 26, 638-652 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 638-652
    • Broz, M.L.1    Binnewies, M.2    Boldajipour, B.3
  • 31
    • 70349336496 scopus 로고    scopus 로고
    • The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease
    • Hercus TR, Thomas D, Guthridge MA et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood 114, 1289-1298 (2009).
    • (2009) Blood , vol.114 , pp. 1289-1298
    • Hercus, T.R.1    Thomas, D.2    Guthridge, M.A.3
  • 32
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff G, Jaffee E, Lazenby A et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl Acad. Sci. USA 90, 3539-3543 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3
  • 33
    • 0035720479 scopus 로고    scopus 로고
    • Perilesional injection of r-GM-CSF in patients with cutaneous melanoma metastases
    • Hoeller C, Jansen B, Heere-Ress E et al. Perilesional injection of r-GM-CSF in patients with cutaneous melanoma metastases. J. Invest. Dermatol. 117, 371-374 (2001).
    • (2001) J. Invest. Dermatol. , vol.117 , pp. 371-374
    • Hoeller, C.1    Jansen, B.2    Heere-Ress, E.3
  • 34
    • 84977111376 scopus 로고    scopus 로고
    • Current status of granulocyte-macrophage colony-stimulating factor in the immunotherapy of melanoma
    • Kaufman HL, Ruby CE, Hughes T et al. Current status of granulocyte-macrophage colony-stimulating factor in the immunotherapy of melanoma. J. Immunother. Cancer 2, 11 (2014).
    • (2014) J. Immunother. Cancer , vol.2 , pp. 11
    • Kaufman, H.L.1    Ruby, C.E.2    Hughes, T.3
  • 35
    • 0034294865 scopus 로고    scopus 로고
    • Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor
    • Toda M, Martuza RL, Rabkin SD. Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor. Mol. Ther. 2, 324-329 (2000).
    • (2000) Mol. Ther. , vol.2 , pp. 324-329
    • Toda, M.1    Martuza, R.L.2    Rabkin, S.D.3
  • 36
    • 84893937889 scopus 로고    scopus 로고
    • Intralesional immunotherapy for melanoma
    • Hersey P, Gallagher S. Intralesional immunotherapy for melanoma. J. Surg. Oncol. 109, 320-326 (2014).
    • (2014) J. Surg. Oncol. , vol.109 , pp. 320-326
    • Hersey, P.1    Gallagher, S.2
  • 37
    • 84907521153 scopus 로고    scopus 로고
    • Primary overall survival (OS) from OPTiM, a randomized Phase III trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma
    • Kaufman HL, Andtbacka RHI, Collichio FA, Amatruda T, Senzer NN et al. Primary overall survival (OS) from OPTiM, a randomized Phase III trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma. J. Clin. Oncol. 32, 9008-abstr (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 9008
    • Kaufman, H.L.1    Andtbacka, R.H.I.2    Collichio, F.A.3    Amatruda, T.4    Senzer, N.N.5
  • 38
    • 84897476768 scopus 로고    scopus 로고
    • Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
    • Zamarin D, Holmgaard RB, Subudhi SK et al. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci. Transl. Med. 6, 226ra32 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 226ra32
    • Zamarin, D.1    Holmgaard, R.B.2    Subudhi, S.K.3
  • 39
    • 73349133717 scopus 로고    scopus 로고
    • Phase II clinical trial of a granulocyte-macrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma
    • Senzer NN, Kaufman HL, Amatruda T et al. Phase II clinical trial of a granulocyte-macrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma. J. Clin. Oncol. 27, 5763-5771 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5763-5771
    • Senzer, N.N.1    Kaufman, H.L.2    Amatruda, T.3
  • 40
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O'Day S et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin. Cancer Res. 15, 7412-7420 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 41
    • 34447258415 scopus 로고    scopus 로고
    • Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine
    • Filipazzi P, Valenti R, Huber V et al. Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. J. Clin. Oncol. 25, 2546-2553 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 2546-2553
    • Filipazzi, P.1    Valenti, R.2    Huber, V.3
  • 42
    • 84868240415 scopus 로고    scopus 로고
    • Differing patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-alpha or TLR-9 agonist and GM-CSF with peptide vaccination
    • Tarhini AA, Butterfield LH, Shuai Y et al. Differing patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-alpha or TLR-9 agonist and GM-CSF with peptide vaccination. J. Immunother. 35, 702-710 (2012).
    • (2012) J. Immunother. , vol.35 , pp. 702-710
    • Tarhini, A.A.1    Butterfield, L.H.2    Shuai, Y.3
  • 43
    • 84964314651 scopus 로고    scopus 로고
    • CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy
    • Engeland CE, Grossardt C, Veinalde R et al. CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy. Mol. Ther. 22, 1949-1959 (2014).
    • (2014) Mol. Ther. , vol.22 , pp. 1949-1959
    • Engeland, C.E.1    Grossardt, C.2    Veinalde, R.3
  • 44
    • 84905008082 scopus 로고    scopus 로고
    • Primary analysis of a Phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma
    • Puzanov I, Milhem MM, Andtbacka RH, Minor DR, Hamid O et al. Primary analysis of a Phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma. J. Clin. Oncol. 32, 9029-abstr. (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 9029
    • Puzanov, I.1    Milhem, M.M.2    Andtbacka, R.H.3    Minor, D.R.4    Hamid, O.5
  • 45
    • 33846650370 scopus 로고    scopus 로고
    • Clinical trial results with oncolytic virotherapy: A century of promise, a decade of progress
    • Liu TC, Galanis E, Kirn D. Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress. Nat. Clin. Pract. Oncol. 4, 101-117 (2007).
    • (2007) Nat. Clin. Pract. Oncol. , vol.4 , pp. 101-117
    • Liu, T.C.1    Galanis, E.2    Kirn, D.3
  • 46
    • 77952238515 scopus 로고    scopus 로고
    • A Phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma
    • Bedikian AY, Richards J, Kharkevitch D et al. A Phase 2 study of high-dose Allovectin-7 in patients with advanced metastatic melanoma. Melanoma Res. 20, 218-226 (2010).
    • (2010) Melanoma Res. , vol.20 , pp. 218-226
    • Bedikian, A.Y.1    Richards, J.2    Kharkevitch, D.3
  • 47
    • 1642453768 scopus 로고    scopus 로고
    • Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, coxsackievirus a21
    • Shafren DR, Au GG, Nguyen T et al. Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, coxsackievirus a21. Clin. Cancer Res. 10, 53-60 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 53-60
    • Shafren, D.R.1    Au, G.G.2    Nguyen, T.3
  • 48
    • 84937723705 scopus 로고    scopus 로고
    • Abstract 2939: CAVATAK-mediated oncolytic immunotherapy in advanced melanoma patients
    • Andtbacka RH, Shafren DR, Grose M, Post L, Weisberg J. Abstract 2939: CAVATAK-mediated oncolytic immunotherapy in advanced melanoma patients. Cancer Res. 74, 2939 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 2939
    • Andtbacka, R.H.1    Shafren, D.R.2    Grose, M.3    Post, L.4    Weisberg, J.5
  • 49
    • 84880437254 scopus 로고    scopus 로고
    • Intralesional injection of rose bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer
    • Toomey P, Kodumudi K, Weber A et al. Intralesional injection of rose bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer. PLoS ONE 8, e68561 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e68561
    • Toomey, P.1    Kodumudi, K.2    Weber, A.3
  • 50
    • 84937677060 scopus 로고    scopus 로고
    • Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in Phase II study PV-10-MM-02
    • Agarwala SS, Thompson JF, Smithers BM, Ross MI, Scoggins CR et al. Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in Phase II study PV-10-MM-02. J. Clin. Oncol. 32, 9027 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 9027
    • Agarwala, S.S.1    Thompson, J.F.2    Smithers, B.M.3    Ross, M.I.4    Scoggins, C.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.