Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch

Journal of the American Chemical Society

Volumn 137, Issue 28, 2015, Pages 9015-9021

  Wu, Ming Cheng ^a,b   Lowe, Phillip T ^a,c   Robinson, Christopher J ^a   Vincent, Helen A ^a   Dixon, Neil ^a   Leigh, James ^a   Micklefield, Jason ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; BIOTECHNOLOGY; GENES; LIGANDS; REENGINEERING; TRANSCRIPTION;

ANTIMICROBIAL TARGETS; BIOTECHNOLOGICAL APPLICATIONS; CELLULAR METABOLITES; SCREENING APPROACHES; SYNTHETIC COMPOUNDS; SYNTHETIC MOLECULES; TARGET GENE EXPRESSION; TRANSCRIPTIONAL SILENCING;

GENE EXPRESSION;

ADENINE; APTAMER; MESSENGER RNA; 7-(AMINOMETHYL)-7-DEAZAGUANINE; PYRIMIDINONE DERIVATIVE; PYRROLE DERIVATIVE; RIBOSWITCH;

ARTICLE; BACILLUS SUBTILIS; GENE FUNCTION; GENETIC SELECTION; METHODOLOGY; MUTANT; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; RIBOSWITCH; SCREENING; VALIDATION STUDY; CHEMISTRY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC ENGINEERING; GENETICS; METABOLISM; MUTAGENESIS; NUCLEOTIDE SEQUENCE; SYNTHETIC BIOLOGY; TRANSCRIPTION INITIATION;

APTAMERS, NUCLEOTIDE; BACILLUS SUBTILIS; BASE SEQUENCE; GENE EXPRESSION REGULATION, BACTERIAL; GENE SILENCING; GENETIC ENGINEERING; MUTAGENESIS; PYRIMIDINONES; PYRROLES; RIBOSWITCH; SYNTHETIC BIOLOGY; TRANSCRIPTIONAL ACTIVATION;

EID: 84937683269     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b03405     Document Type: Article

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