The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 370, Issue 1676, 2015, Pages

  Yaari, Gur ^a   Benichou, Jennifer I C ^a   Vander Heiden, Jason A ^b   Kleinstein, Steven H ^b,c   Louzoun, Yoram ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b YALE UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Affinity maturation; Antigen driven selection; B cell receptor; Lineage trees; Mutations; Next generation sequencing

Indexed keywords

BLOOD; CLONE; GENE FLOW; GERM CELL; IMMUNE RESPONSE; MUTATION; PROTEIN; TIMESCALE;

COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN MEDIATED CLONAL SELECTION; B LYMPHOCYTE; BIOLOGICAL MODEL; CELL LINEAGE; COMPLEMENTARITY DETERMINING REGION; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MUTATION; SOMATIC HYPERMUTATION; TIME FACTOR;

ANTIBODY AFFINITY; ANTIBODY DIVERSITY; B-LYMPHOCYTES; CELL LINEAGE; CLONAL SELECTION, ANTIGEN-MEDIATED; COMPLEMENTARITY DETERMINING REGIONS; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MODELS, GENETIC; MODELS, IMMUNOLOGICAL; MUTATION; RECEPTORS, ANTIGEN, B-CELL; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TIME FACTORS;

EID: 84937681813     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2014.0242     Document Type: Article

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