Molecular identification of aminoglycoside-modifying enzymes in clinical isolates of Escherichia coli resistant to amoxicillin/clavulanic acid isolated in Spain

International Journal of Antimicrobial Agents

Volumn 46, Issue 2, 2015, Pages 157-163

  Fernández Martínez, Marta ^a   Miró, Elisenda ^b   Ortega, Adriana ^c   Bou, Germán ^d   González López, Juan José ^e   Oliver, Antonio ^f   Pascual, Alvaro ^g   Cercenado, Emilia ^h   Oteo, Jesús ^c   Martínez Martínez, Luis ^a   Navarro, Ferran ^i,j  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL JUAN CANALEJO   (Spain)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^g HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

^h HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

ⁱ UNIVERSITY OF CANTABRIA   (Spain)

^j UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

more..

Author keywords

Aminoglycoside; Aminoglycoside modifying enzyme; Amoxicillin clavulanic acid; Escherichia coli; Resistance

Indexed keywords

16S RRNA METHYLASE; AMIKACIN; AMINOGLYCOSIDE MODIFYING ENZYME; AMOXICILLIN PLUS CLAVULANIC ACID; APRAMYCIN; BACTERIAL ENZYME; BETA LACTAMASE; BETA LACTAMASE CTX M 15; BETA LACTAMASE OXA 1; GENTAMICIN; HABEKACIN; KANAMYCIN; NEOMYCIN; NETILMICIN; RNA METHYLTRANSFERASE; TOBRAMYCIN; UNCLASSIFIED DRUG; ACYLTRANSFERASE; AMINOGLYCOSIDE; AMINOGLYCOSIDE ACETYLTRANSFERASE; AMOXICILLIN; ANTIINFECTIVE AGENT; CLAVULANIC ACID; GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE; KANAMYCIN KINASE; NUCLEOTIDYLTRANSFERASE; RNA 16S; TRANSFER RNA METHYLTRANSFERASE;

AAC(2'') IA GENE; AAC(3) IA GENE; AAC(3) IIA GENE; AAC(3) IVA GENE; AAC(6') IB GENE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; APH(3') IA GENE; ARMA GENE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BROTH DILUTION; CONTROLLED STUDY; ENZYME ANALYSIS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR GENETICS; NONHUMAN; NPMA GENE; PHENOTYPE; PRIORITY JOURNAL; RMTB GENE; RMTC GENE; SPAIN; CLINICAL TRIAL; CLUSTER ANALYSIS; DRUG INACTIVATION; ENZYMOLOGY; ESCHERICHIA COLI INFECTION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTICENTER STUDY;

ACETYLTRANSFERASES; AMINOGLYCOSIDES; AMOXICILLIN; ANTI-BACTERIAL AGENTS; CLAVULANIC ACID; CLUSTER ANALYSIS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMANS; INACTIVATION, METABOLIC; KANAMYCIN KINASE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; NUCLEOTIDYLTRANSFERASES; RNA, RIBOSOMAL, 16S; SPAIN; TRNA METHYLTRANSFERASES;

EID: 84937640433     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2015.03.008     Document Type: Article

References (30)

1. I. Galani, M. Souli, G.L. Daikos, Z. Chrysouli, G. Poulakou, M. Psichogiou, and et al. Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece J Chemother 24 2012 191 194
2. J.B. Aggen, E.S. Armstrong, A.A. Goldblum, P. Dozzo, M.S. Linsell, M.J. Gliedt, and et al. Synthesis and spectrum of the neoglycoside ACHN-490 Antimicrob Agents Chemother 54 2010 4636 4642
3. J. Campos, M. Ferech, E. Lázaro, F. de Abajo, J. Oteo, P. Stephens, and et al. Surveillance of outpatient antibiotic consumption in Spain according to sales data and reimbursement data J Antimicrob Chemother 60 2007 698 701
4. A. Ortega, J. Oteo, M. Aranzamendi-Zaldumbide, R.M. Bartolomé, G. Bou, E. Cercenado, and et al. Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli Antimicrob Agents Chemother 56 2012 3576 3581
5. K. Poole Efflux-mediated multiresistance in Gram-negative bacteria Clin Microbiol Infect 10 2004 12 26
6. E.H. Nakamatsu, E. Fujihira, R.C. Ferreira, A. Balan, S.O. Costa, and L.C. Ferreira Oligopeptide uptake and aminoglycoside resistance in Escherichia coli K12 FEMS Microbiol Lett 269 2007 229 233
7. M.S. Ramirez, and E. Tolmasky Aminoglycoside modifying enzymes Drug Resist Updat 13 2010 151 171
8. K.J. Shaw, P.N. Rather, R.S. Hare, and G.H. Miller Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes Microbiol Rev 57 1993 138 163
9. J. Wachino, and Y. Arakawa Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update Drug Resist Updat 15 2012 133 148
10. Y. Doi, and Y. Arakawa 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides Clin Infect Dis 45 2007 88 94
11. D.M. Livermore, T.G. Winstanley, and K.P. Shannon Interpretative reading: recognizing the unusual and inferring resistance mechanisms from resistance phenotypes J Antimicrob Chemother 48 Suppl 1 2001 87 102
12. P.C. Lindemann, K. Risberg, H.G. Wiker, and H. Mylvaganam Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from western Norway APMIS 120 2011 495 502
13. D.M. Livermore, S. Mushtaq, M. Warner, J.C. Zhang, S. Maharjan, M. Doumith, and et al. Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates J Antimicrob Chemother 66 2011 48 53
14. R. Almaghrabi, C.J. Clancy, Y. Doi, B. Hao, L. Chen, R.K. Shields, and et al. Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents Antimicrob Agents Chemother 58 2014 4443 4451
15. J. Rodríguez-Baño, J. Oteo, A. Ortega, M. Villar, M.C. Conejo, G. Bou, and et al. Epidemiological and clinical complexity of amoxicillin-clavulanate-resistant Escherichia coli J Clin Microbiol 51 2013 2414 2417
16. Clinical and Laboratory Standards Institute Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard - ninth edition. Document M07-A9 2012 CLSI Wayne, PA
17. European Committee on Antimicrobial Susceptibility Testing Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1 2013 European Committee on Antimicrobial Susceptibility Testing [accessed 16 April 2015]
18. European Food Safety Authority Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Guidance on the assessment of bacterial susceptibility to antimicrobials of human and veterinary importance EFSA J 10 2012 2740
19. M.W. Vetting, C.H. Park, S.S. Hegde, G.A. Jacoby, D.C. Hooper, and J.S. Blanchard Mechanistic and structural analysis of aminoglycoside N-acetyl-transferase AAC(6′)-Ib and its bifunctional, fluoroquinolone-active AAC(6′)-Ib-cr variant Biochemistry 47 2008 9825 9835
20. J. Oteo, J.J. González-López, A. Ortega, J.N. Quintero-Zárate, G. Bou, E. Cercenado, and et al. Inhibitor-resistant TEM- and OXA-1-producing Escherichia coli isolates resistant to amoxicillin-clavulanate are more clonal and possess lower virulence gene content than susceptible clinical isolates Antimicrob Agents Chemother 58 2014 3874 3881
21. E. Miró, F. Grünbaum, L. Gómez, A. Rivera, B. Mirelis, P. Coll, and et al. Characterization of aminoglycoside-modifying enzymes in Enterobacteriaceae clinical strains and characterization of the plasmids implicated in their diffusion Microb Drug Resist 19 2013 94 99
22. C. Kosmidis, M. Giannopoulou, A. Flountzi, A. Markogiannakis, D. Goukos, G. Petrikkos, and et al. Genetic basis of aminoglycoside resistance following changes in aminoglycoside prescription patterns J Chemother 25 2013 217 221
23. F.J. Schmitz, J. Verhoef, A.C. Fluit SENTRY Participants Group Prevalence of aminoglycoside resistance in 20 European university hospitals participating in the European SENTRY Antimicrobial Surveillance Programme Eur J Clin Microbiol Infect Dis 18 1999 414 421
24. R. Vanhoof, H.J. Nyssen, E. Van Bossuyt, E. Hannecart-Pokorni Aminoglycoside Resistance Study Group Aminoglycoside resistance in Gram-negative blood isolates from various hospitals in Belgium and Grand Duchy of Luxembourg J Antimicrob Chemother 44 1999 483 488
25. E. Ruiz, A.A. Ocampo-Sosa, J. Alcoba-Flórez, E. Román, G. Arlet, C. Torres, and et al. Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6′)-Ib-cr gene Antimicrob Agents Chemother 56 2012 1097 1100
26. M.S. Ramirez, N. Nikolaidis, and M.E. Tolmasky Rise and dissemination of aminoglycoside resistance: the aac(6′)-Ib paradigm Front Microbiol 4 2013 121
27. S.Y. Kim, Y.J. Park, J.K. Yu, and Y.S. Kim Aminoglycoside susceptibility profiles of Enterobacter cloacae isolates harboring the aac(6′)-Ib gene Korean J Lab Med 31 2011 279 281
28. M.A. Davis, T.E. Besser, L.H. Orfe, K.N. Baker, A.S. Lanier, S.L. Broschat, and et al. Genotypic-phenotypic discrepancies between antibiotic resistance characteristics of Escherichia coli isolates from calves in management settings with high and low antibiotic use Appl Environ Microbiol 77 2011 3293 3299
29. E. Machado, T.M. Coque, R. Cantón, F. Baquero, J.C. Sousa, L. Peixe, and et al. Dissemination in Portugal of CTX-M-15-, OXA-1-, and TEM-1-producing Enterobacteriaceae strains containing the aac(6′)-Ib-cr gene, which encodes an aminoglycoside and fluoroquinolone-modifying enzyme Antimicrob Agents Chemother 50 2006 3220 3221
30. E. Karisik, M.J. Ellington, R. Pike, R.E. Warren, D.M. Livermore, and N. Woodford Molecular characterization of plasmids encoding CTX-M-15 β-lactamases from Escherichia coli strains in the United Kingdom J Antimicrob Chemother 58 2006 665 668