Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron-sulfur cluster assembly

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1854, Issue 9, 2015, Pages 1113-1117

  Yan, Robert ^a   Adinolfi, Salvatore ^a   Pastore, Annalisa ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Electron transfer; Enzymology; Friedreich's ataxia; Iron sulfur cluster biogenesis; Metabolic machines

Indexed keywords

CYAY PROTEIN; DITHIOTHREITOL; FERREDOXIN; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; IRON SULFUR PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME SUBSTRATE COMPLEX; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REDUCTION;

EID: 84937631191     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2015.02.002     Document Type: Article

References (21)

1. R. Lill Function and biogenesis of iron-sulphur proteins Nature 460 2009 831
2. Y. Takahashi, and M. Nakamura Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli J. Biochem. (Tokyo) 126 1999 917
3. E. Behshad, and J.M. Bollinger Jr. Kinetic analysis of cysteine desulfurase CD0387 from Synechocystis sp PCC 6803: formation of the persulfide intermediate Biochemistry 48 2009 12014
4. E. Behshad, S.E. Parkin, and J.M. Bollinger Mechanism of cysteine desulfurase Slr0387 from Synechocystis sp PCC 6803: kinetic analysis of cleavage of the persulfide intermediate by chemical reductants Biochemistry 43 2004 12220
5. L.M. Zheng, V.L. Cash, D.H. Flint, and D.R. Dean Assembly of iron-sulfur clusters - identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii J. Biol. Chem. 273 1998 13264
6. R. Shi, A. Proteau, M. Villarroya, I. Moukadiri, L.H. Zhang, J.F. Trempe, A. Matte, M.E. Armengod, and M. Cygler Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions PLoS Biol. 8 2010 18
7. E.N. Marinoni, J.S. de Oliveira, Y. Nicolet, E.C. Raulfs, P. Amara, D.R. Dean, and J.C. Fontecilla-Camps (IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer Angew. Chem. Int. Ed. 51 2012 5439
8. A. Pastore, and H. Puccio Frataxin: a protein in search for a function J. Neurochem. 126 2013 43
9. G. Alper, and V. Narayanan Friedreich's ataxia Pediatr. Neurol. 28 2003 335
10. K.M. Ewen, M. Kleser, and R. Bernhardt Adrenodoxin: the archetype of vertebrate-type [2Fe-2S] cluster ferredoxins Biochim. Biophys. Acta Protein Proteomics 1814 2011 111
11. H. Lange, A. Kaut, G. Kispal, and R. Lill A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins Proc. Natl. Acad. Sci. U. S. A. 97 2000 1050
12. R. Miao, M. Martinho, J.G. Morales, H. Kim, E.A. Ellis, R. Lill, M.P. Hendrich, E. Munck, and P.A. Lindahl EPR and Mossbauer spectroscopy of intact mitochondria isolated from Yah1p-depleted Saccharomyces cerevisiae Biochemistry 47 2008 9888
13. A.D. Sheftel, O. Stehling, A.J. Pierik, H.-P. Elsaesser, U. Muehlenhoff, H. Webert, A. Hobler, F. Hannemann, R. Bernhardt, and R. Lill Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis Proc. Natl. Acad. Sci. U. S. A. 107 2010 11775
14. U. Tokumoto, and Y. Takahashi Genetic analysis of the isc operon in Escherichia coli involved in the biogenesis of cellular iron-sulfur protein J. Biochem. (Tokyo) 130 2001 63
15. A.V. Grinberg, F. Hannemann, B. Schiffler, J. Muller, U. Heinemann, and R. Bernhardt Adrenodoxin: structure, stability, and electron transfer properties Proteins Struct. Funct. Genet. 40 2000 590
16. R. Yan, P.V. Konarev, C. Iannuzzi, S. Adinolfi, B. Roche, G. Kelly, L. Simon, S.R. Martin, B. Py, F. Barras, D.I. Svergun, and A. Pastore Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS J. Biol. Chem. 288 2013 24777
17. J.H. Kim, R.O. Frederick, N.M. Reinen, A.T. Troupis, and J.L. Markley 2Fe-2S ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin J. Am. Chem. Soc. 135 2013 8117
18. F. Prischi, P.V. Konarev, C. Iannuzzi, C. Pastore, S. Adinolfi, S.R. Martin, D.I. Svergun, and A. Pastore Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly Nat. Commun. 1 2010
19. S. Adinolfi, F. Rizzo, L. Masino, M. Nair, S.R. Martin, A. Pastore, and P.A. Temussi Bacterial IscU is a well folded and functional single domain protein Eur. J. Biochem. 271 2004 2093
20. S. Adinolfi, C. Iannuzzi, F. Prischi, C. Pastore, S. Iametti, S.R. Martin, F. Bonomi, and A. Pastore Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS Nat. Struct. Mol. Biol. 16 2009 390
21. G. Kurisu, M. Kusunoki, E. Katoh, T. Yamazaki, K. Teshima, Y. Onda, Y. Kimata-Ariga, and T. Hase Structure of the electron transfer complex between ferredoxin and ferredoxin-NADP(+) reductase Nat. Struct. Biol. 8 2001 117