Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study

Anesthesiology

Volumn 122, Issue 5, 2015, Pages 1123-1141

  Montes, Antonio ^a   Roca, Gisela ^b   Sabate, Sergi ^c   Lao, Jose Ignacio ^d   Navarro, Arcadi ^e   Cantillo, Jordi ^a   Canet, Jaume ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^c FUNDACIÓ PUIGVERT   (Spain)

^d Genomic Genetics International   (Spain)

^e CENTRE FOR GENOMIC REGULATION CRG   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID RECEPTOR; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; DELTA OPIATE RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; FATTY ACID AMIDASE; GLUTAMATE RECEPTOR; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INTERLEUKIN 10; INTERLEUKIN 6; IONOTROPIC RECEPTOR; KAPPA OPIATE RECEPTOR; MELANOCORTIN 4 RECEPTOR; MU OPIATE RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; PROENKEPHALIN; PROOPIOMELANOCORTIN; PROSTAGLANDIN SYNTHASE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SEROTONIN 2C RECEPTOR; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; TRANSFORMING GROWTH FACTOR BETA1; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TUMOR NECROSIS FACTOR; TYROSINE 3 MONOOXYGENASE;

ABDOMINAL HYSTERECTOMY; ADULT; AGE; AGED; ARTICLE; CHRONIC PAIN; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; HEREDITY; HERNIOPLASTY; HUMAN; HYSTERECTOMY; INGUINAL HERNIA; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MIDDLE AGED; MULTICENTER STUDY; OUTCOME ASSESSMENT; PHYSICAL EXAMINATION; POSTOPERATIVE PAIN; PREDICTOR VARIABLE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SHORT FORM 12; SINGLE NUCLEOTIDE POLYMORPHISM; SURGICAL RISK; THORACOTOMY; VAGINAL HYSTERECTOMY; ADVERSE EFFECTS; CHRONIC DISEASE; CLINICAL TRIAL; FOLLOW UP; GENETICS; HEALTH STATUS; HERNIORRHAPHY; PAIN, POSTOPERATIVE; RISK FACTOR; TREATMENT OUTCOME;

ADULT; AGE FACTORS; AGED; CHRONIC DISEASE; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HEALTH STATUS; HERNIORRHAPHY; HUMANS; HYSTERECTOMY; MALE; MENTAL HEALTH; MIDDLE AGED; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; RISK FACTORS; THORACOTOMY; TREATMENT OUTCOME;

EID: 84937604236     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000611     Document Type: Article

References (59)

1. Crombie IK, Davies HT, Macrae WA, Cut and thrust: Antecedent surgery and trauma among patients attending a chronic pain clinic. Pain 1998 76 167 71
2. Johansen A, Romundstad L, Nielsen CS, Schirmer H, Stubhaug A, Persistent postsurgical pain in a general population: Prevalence and predictors in the Tromsø study. Pain 2012 153 1390 6
3. Kehlet H, Jensen TS, Woolf CJ, Persistent postsurgical pain: Risk factors and prevention. Lancet 2006 367 1618 25
4. Lavand'homme P, The progression from acute to chronic pain. Curr Opin Anaesthesiol 2011 24 545 50
5. Macrae WA, Chronic post-surgical pain: 10 years on. Br J Anaesth 2008 101 77 86
6. Kalso E, IV. Persistent post-surgery pain: Research agenda for mechanisms, prevention, and treatment. Br J Anaesth 2013 111 9 12
7. Schnabel A, Pogatzki-Zahn E, [Predictors of chronic pain following surgery: What do we know?]. Schmerz 2010 24 517 31
8. Kristensen AD, Pedersen TA, Hjortdal VE, Jensen TS, Nikolajsen L, Chronic pain in adults after thoracotomy in childhood or youth. Br J Anaesth 2010 104 75 9
9. Hinrichs-Rocker A, Schulz K, Järvinen I, Lefering R, Simanski C, Neugebauer EA, Psychosocial predictors and correlates for chronic post-surgical pain (CPSP)-A systematic review. Eur J Pain 2009 13 719 30
10. Khan RS, Ahmed K, Blakeway E, Skapinakis P, Nihoyannopoulos L, Macleod K, Sevdalis N, Ashrafian H, Platt M, Darzi A, Athanasiou T, Catastrophizing: A predictive factor for postoperative pain. Am J Surg 2011 201 122 31
11. Gärtner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H, Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA 2009 302 1985 92
12. Aasvang E, Kehlet H, Chronic postoperative pain: The case of inguinal herniorrhaphy. Br J Anaesth 2005 95 69 76
13. Smeds S, Löfström L, Eriksson O, Influence of nerve identification and the resection of nerves 'at risk' on postoperative pain in open inguinal hernia repair. Hernia 2010 14 265 70
14. Yarnitsky D, Crispel Y, Eisenberg E, Granovsky Y, Ben-Nun A, Sprecher E, Best LA, Granot M, Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk. Pain 2008 138 22 8
15. Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ, GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006 12 1269 77
16. Lee PJ, Delaney P, Keogh J, Sleeman D, Shorten GD, Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity. Clin J Pain 2011 27 93 101
17. Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Martinez A, Lao-Villadóniga JI, García-Fructuoso F, Vallejo M, Martínez-Lavín M, Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains. Arthritis Rheum 2009 60 2169 73
18. Lötsch J, Geisslinger G, Current evidence for a genetic modulation of the response to analgesics. Pain 2006 121 1 5
19. Stamer UM, Stüber F, Genetic factors in pain and its treatment. Curr Opin Anaesthesiol 2007 20 478 84
20. Kim H, Ramsay E, Lee H, Wahl S, Dionne RA, Genome-wide association study of acute post-surgical pain in humans. Pharmacogenomics 2009 10 171 9
21. Dominguez CA, Kalliomäki M, Gunnarsson U, Moen A, Sandblom G, Kockum I, Lavant E, Olsson T, Nyberg F, Rygh LJ, Røe C, Gjerstad J, Gordh T, Piehl F, The DQB1 ∗03:02 HLA haplotype is associated with increased risk of chronic pain after inguinal hernia surgery and lumbar disc herniation. Pain 2013 154 427 33
22. Macrae WA, Davies HT, Crombie IK, Linton S, Croft P, Von Korff M, Le Resche L, Chronic postsurgical pain. Epidemiology of Pain 1999 Seattle International Association for the Study of Pain 125 42
23. Wildgaard K, Ravn J, Kehlet H, Chronic post-thoracotomy pain: A critical review of pathogenic mechanisms and strategies for prevention. Eur J Cardiothorac Surg 2009 36 170 80
24. Nienhuijs S, Staal E, Strobbe L, Rosman C, Groenewoud H, Bleichrodt R, Chronic pain after mesh repair of inguinal hernia: A systematic review. Am J Surg 2007 194 394 400
25. Searle RD, Simpson MP, Simpson KH, Milton R, Bennett MI, Can chronic neuropathic pain following thoracic surgery be predicted during the postoperative period? Interact Cardiovasc Thorac Surg 2009 9 999 1002
26. Herrero MJ, Blanch J, Peri JM, De Pablo J, Pintor L, Bulbena A, A validation study of the hospital anxiety and depression scale (HADS) in a Spanish population. Gen Hosp Psychiatry 2003 25 277 83
27. Zigmond AS, Snaith RP, The hospital anxiety and depression scale. Acta Psychiatr Scand 1983 67 361 70
28. Schmidt S, Vilagut G, Garin O, Cunillera O, Tresserras R, Brugulat P, Mompart A, Medina A, Ferrer M, Alonso J, [Reference guidelines for the 12-Item Short-Form Health Survey version 2 based on the Catalan general population]. Med Clin (Barc) 2012 139 613 25
29. Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B, Bruxelle J, Cunin G, Fermanian J, Ginies P, Grun-Overdyking A, Jafari-Schluep H, Lantéri-Minet M, Laurent B, Mick G, Serrie A, Valade D, Vicaut E, Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 2005 114 29 36
30. Evans DM, Purcell S, Power calculations in genetic studies. Cold Spring Harb Protoc 2012 2012 664 74
31. Sabaté S, Canet J, Gomar C, Castillo J, Villalonga A, Investigateurs ANESCAT [Cross-sectional survey of anaesthetic practices in Catalonia, Spain]. Ann Fr Anesth Reanim 2008 27 371 83
32. MacGregor AJ, Andrew T, Sambrook PN, Spector TD, Structural, psychological, and genetic influences on low back and neck pain: A study of adult female twins. Arthritis Rheum 2004 51 160 7
33. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W, Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005 14 135 43
34. Palm F, Mössner R, Chen Y, He L, Gerlach M, Bischofs S, Riederer P, Lesch KP, Sommer C, Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter. Eur J Pain 2008 12 790 7
35. Mogil JS, Pain genetics: Past, present and future. Trends Genet 2012 28 258 66
36. Hoh J, Wille A, Ott J, Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res 2001 11 2115 9
37. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA, Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004 74 106 20
38. Brandsborg B, Nikolajsen L, Hansen CT, Kehlet H, Jensen TS, Risk factors for chronic pain after hysterectomy: A nationwide questionnaire and database study. A nesthesiology 2007 106 1003 12
39. Morcillo-Suarez C, Alegre J, Sangros R, Gazave E, de Cid R, Milne R, Amigo J, Ferrer-Admetlla A, Moreno-Estrada A, Gardner M, Casals F, Pérez-Lezaun A, Comas D, Bosch E, Calafell F, Bertranpetit J, Navarro A, SNP analysis to results (SNPator): A web-based environment oriented to statistical genomics analyses upon SNP data. Bioinformatics 2008 24 1643 4
40. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC, PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007 81 559 75
41. Stephens M, Smith NJ, Donnelly P, A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001 68 978 89
42. Guastella V, Mick G, Soriano C, Vallet L, Escande G, Dubray C, Eschalier A, A prospective study of neuropathic pain induced by thoracotomy: Incidence, clinical description, and diagnosis. Pain 2011 152 74 81
43. Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, Romano R, Lee ML, Xiao T, Papp A, Wang D, Sadée W, Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci USA 2007 104 20552 7
44. Laucht M, Becker K, Frank J, Schmidt MH, Esser G, Treutlein J, Skowronek MH, Schumann G, Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence. J Am Acad Child Adolesc Psychiatry 2008 47 673 81
45. Hamidovic A, Dlugos A, Skol A, Palmer AA, de Wit H, Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: An exploratory study with d-amphetamine in healthy participants. Exp Clin Psychopharmacol 2009 17 374 83
46. Caldeiro RM, Malte CA, Calsyn DA, Baer JS, Nichol P, Kivlahan DR, Saxon AJ, The association of persistent pain with out-patient addiction treatment outcomes and service utilization. Addiction 2008 103 1996 2005
47. Nissenbaum J, Devor M, Seltzer Z, Gebauer M, Michaelis M, Tal M, Dorfman R, Abitbul-Yarkoni M, Lu Y, Elahipanah T, delCanho S, Minert A, Fried K, Persson AK, Shpigler H, Shabo E, Yakir B, Pisanté A, Darvasi A, Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2. Genome Res 2010 20 1180 90
48. Kolesnikov Y, Gabovits B, Levin A, Veske A, Qin L, Dai F, Belfer I, Chronic pain after lower abdominal surgery: Do catechol-O-methyl transferase/opioid receptor μ-1 polymorphisms contribute? Mol Pain 2013 9 19
49. Althaus A, Hinrichs-Rocker A, Chapman R, Arránz Becker O, Lefering R, Simanski C, Weber F, Moser KH, Joppich R, Trojan S, Gutzeit N, Neugebauer E, Development of a risk index for the prediction of chronic post-surgical pain. Eur J Pain 2012 16 901 10
50. Rollman GB, Perspectives on hypervigilance. Pain 2009 141 183 4
51. Wood PB, Role of central dopamine in pain and analgesia. Expert Rev Neurother 2008 8 781 97
52. Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T, Sensitization in patients with painful knee osteoarthritis. Pain 2010 149 573 81
53. Kehlet H, Rathmell JP, Persistent postsurgical pain: The path forward through better design of clinical studies. A nesthesiology 2010 112 514 5
54. VanDenKerkhof EG, Peters ML, Bruce J, Chronic pain after surgery: Time for standardization? A framework to establish core risk factor and outcome domains for epidemiological studies. Clin J Pain 2013 29 2 8
55. Tasmuth T, Blomqvist C, Kalso E, Chronic post-treatment symptoms in patients with breast cancer operated in different surgical units. Eur J Surg Oncol 1999 25 38 43
56. Riddle DL, Wade JB, Jiranek WA, Kong X, Preoperative pain catastrophizing predicts pain outcome after knee arthroplasty. Clin Orthop Relat Res 2010 468 798 806
57. Fitzgibbons RJ Jr, Giobbie-Hurder A, Gibbs JO, Dunlop DD, Reda DJ, McCarthy M Jr, Neumayer LA, Barkun JS, Hoehn JL, Murphy JT, Sarosi GA Jr, Syme WC, Thompson JS, Wang J, Jonasson O, Watchful waiting vs repair of inguinal hernia in minimally symptomatic men: A randomized clinical trial. JAMA 2006 295 285 92
58. Martinez V, Baudic S, Fletcher D, [Chronic postsurgical pain]. Ann Fr Anesth Reanim 2013 32 422 35
59. Dworkin RH, McDermott MP, Raja SN, Preventing chronic postsurgical pain: How much of a difference makes a difference? A nesthesiology 2010 112 516 8