Up-Regulation of FOXM1 by E6 Oncoprotein through the MZF1/NKX2-1 Axis Is Required for Human Papillomavirus-Associated Tumorigenesis

Neoplasia (United States)

Volumn 16, Issue 11, 2014, Pages 961-971

  Chen, Po Ming ^a   Cheng, Ya Wen ^a   Wang, Yao Chen ^b,c   Wu, Tzu Chin ^b,c   Chen, Chih Yi ^d   Lee, Huei ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO 3 (3,5 DIMETHYL 1,3 HEPTADIEN 1 YL) 7,8 DIHYDRO 7,8 DIHYDROXY 7 METHYLBENZO[C]PYRAN 6 ONE; BETA CATENIN; FORKHEAD TRANSCRIPTION FACTOR; GELATINASE A; PROTEIN E6; PROTEIN P53; THIOSTREPTON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXM1; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NKX2 1; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CELL INVASION; CELLS BY BODY ANATOMY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; IMMUNOPRECIPITATION; LUNG CANCER; MAJOR CLINICAL STUDY; METASTASIS; MOUSE; MOUTH CANCER; NONHUMAN; OVERALL SURVIVAL; PAPILLOMAVIRUS INFECTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; TUMOR INVASION; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

EID: 84937558482     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1016/j.neo.2014.09.010     Document Type: Article

References (32)

1. Rositch A.F., Koshiol J., Hudgens M.G., Razzaghi H., Backes D.M., Pimenta J.M., Franco E.L., Poole C., Smith J.S. Patterns of persistent genital human papillomavirus infection among women worldwide: a literature review and meta-analysis. Int J Cancer 2013, 133:1271-1285.
2. Schlecht N.F., Platt R.W., Duarte-Franco E., Costa M.C., Sobrinho J.P., Prado J.C., Ferenczy A., Rohan T.E., Villa L.L., Franco E.L. Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia. J Natl Cancer Inst 2003, 95:1336-1343.
3. Anantharaman D., Gheit T., Waterboer T., Abedi-Ardekani B., Carreira C., McKay-Chopin S., Gaborieau V., Marron M., Lagiou P., Ahrens W. Human papillomavirus infections and upper aero-digestive tract cancers: the ARCAGE study. J Natl Cancer Inst 2013, 105:536-545.
4. Gillison M.L., Shah K.V. Role of mucosal human papillomavirus in nongenital cancers. J Natl Cancer Inst Monogr 2003, 31:57-65.
5. Cheng Y.W., Chiou H.L., Sheu G.T., Hsieh L.L., Chen J.T., Chen C.Y., Su J.M., Lee H. The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res 2001, 61:2799-2803.
6. Cheng Y.W., Wu M.F., Wang J., Yeh K.T., Goan Y.G., Chiou H.L., Chen C.Y., Lee H. Human papillomavirus 16/18 E6 oncoprotein is expressed in lung cancer and related with p53 inactivation. Cancer Res 2007, 67:10686-10693.
7. Fei Y., Yang J., Hsieh W.C., Wu J.Y., Wu T.C., Goan Y.G., Lee H., Cheng Y.W. Different human papillomavirus 16/18 infection in Chinese non-small cell lung cancer patients living in Wuhan, China. Jpn J Clin Oncol 2006, 36:274-279.
8. Koshiol J., Rotunno M., Gillison M.L., Van Doorn L.J., Chaturvedi A.K., Tarantini L., Song H., Quint W.G., Struijk L., Goldstein A.M., et al. Assessment of human papillomavirus in lung tumor tissue. J Natl Cancer Inst 2011, 103:501-507.
9. Moody C.A., Laimins L.A. Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer 2010, 10:550-560.
10. Tung M.C., Wu H.H., Cheng Y.W., Wang L., Chen C.Y., Yeh S.D., Wu T.C., Lee H. Association of epidermal growth factor receptor mutations with human papillomavirus 16/18 E6 oncoprotein expression in non-small cell lung cancer. Cancer 2013, 119:3367-3376.
11. Waseem A., Ali M., Odell E.W., Fortune F., Teh M.T. Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol 2010, 46:536-542.
12. Gemenetzidis E., Bose A., Riaz A.M., Chaplin T., Young B.D., Ali M., Sugden D., Thurlow J.K., Cheong S.C., Teo S.H., et al. FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One 2009, 4:e4849.
13. Yang D.K., Son C.H., Lee S.K., Choi P.J., Lee K.E., Roh M.S. Forkhead box M1 expression in pulmonary squamous cell carcinoma: correlation with clinicopathologic features and its prognostic significance. Hum Pathol 2009, 40:464-470.
14. Xu N., Jia D., Chen W., Wang H., Liu F., Ge H., Zhu X., Song Y., Zhang X., Zhang D. FoxM1 is associated with poor prognosis of non-small cell lung cancer patients through promoting tumor metastasis. PLoS One 2013, 8:e59412.
15. Chan D.W., Yu S.Y., Chiu P.M., Yao K.M., Liu V.W., Cheung A.N., Ngan H.Y. Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis. J Pathol 2008, 215:245-252.
16. Barsotti A.M., Prives C. Pro-proliferative FoxM1 is a target of p53-mediated repression. Oncogene 2009, 28:4295-4305.
17. Millour J., de Olano N., Horimoto Y., Monteiro L.J., Langer J.K., Aligue R., Hajji N., Lam E.W. ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. Mol Cancer Ther 2011, 10:1046-1058.
18. Lüscher-Firzlaff J.M., Westendorf J.M., Zwicker J., Burkhardt H., Henriksson M., Müller R., Pirollet F., Lüscher B. Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation. Oncogene 1999, 18:5620-5630.
19. Chuang C.Y., Sung W.W., Wang L., Lin W.L., Yeh K.T., Su M.C., Hsin C.H., Lee S.Y., Wu B.C., Cheng Y.W., et al. Differential impact of IL-10 expression on survival and relapse between HPV16-positive and -negative oral squamous cell carcinomas. PLoS One 2012, 7:e47541.
20. Sung W.W., Wang Y.C., Lin P.L., Cheng Y.W., Chen C.Y., Wu T.C., Lee H. IL-10 promotes tumor aggressiveness via upregulation of CIP2A transcription in lung adenocarcinoma. Clin Cancer Res 2013, 19:4092-4103.
21. Chang J.T. An economic and efficient method of RNAi vector constructions. Anal Biochem 2004, 334:199-200.
22. Zhang N., Wei P., Gong A., Chiu W.T., Lee H.T., Colman H., Huang H., Xue J., Liu M., Wang Y., et al. FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 2011, 20:427-442.
23. Gong A., Huang S. FoxM1 and Wnt/β-catenin signaling in glioma stem cells. Cancer Res 2012, 72:5658-5662.
24. Park H.J., Gusarova G., Wang Z., Carr J.R., Li J., Kim K.H., Qiu J., Park Y.D., Williamson P.R., Hay N., et al. Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med 2011, 3:21-34.
25. Li Y.J., Tsai Y.C., Chen Y.C., Christiani D.C. Human papilloma virus and female lung adenocarcinoma. Semin Oncol 2009, 36:542-552.
26. Anantharaman D., Gheit T., Waterboer T., Halec G., Carreira C., Abedi-Ardekani B., McKay-Chopin S., Zaridze D., Mukeria A., Szeszenia-Dabrowska N., et al. No causal association identified for human papillomavirus infections in lung cancer. Cancer Res 2014, 74:3525-3534.
27. Ragin C., Obikoya-Malomo M., Kim S., Chen Z., Flores-Obando R., Gibbs D., Koriyama C., Aguayo F., Koshiol J., Caporaso N.E., et al. HPV-associated lung cancers: an international pooled analysis. Carcinogenesis 2014, 35:1267-1275.
28. Dai B., Pieper R.O., Li D., Wei P., Liu M., Woo S.Y., Aldape K.D., Sawaya R., Xie K., Huang S. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res 2010, 70:2951-2961.
29. Huang C., Qiu Z., Wang L., Peng Z., Jia Z., Logsdon C.D., Le X., Wei D., Huang S., Xie K. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res 2012, 72:655-665.
30. Noordhuis M.G., Fehrmann R.S., Wisman G.B., Nijhuis E.R., van Zanden J.J., Moerland P.D., Loren Ver, van Themaat E., Volders H.H., Kok M., et al. Involvement of the TGF-β and β-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer. Clin Cancer Res 2011, 17:1317-1330.
31. Andrews NA, Jones AS, Helliwell TR, Kinsella AR Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases. Br J Cancer 1997, 75:1474-1480.
32. Li X.Q., Yang X.L., Zhang G., Wu S.P., Deng X.B., Xiao S.J., Liu Q.Z., Yao K.T., Xiao G.H. Nuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer. J Transl Med 2013, 11:114.