Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism

American Journal of Transplantation

Volumn 15, Issue 8, 2015, Pages 2231-2239

  Tonsho, M ^a   Lee, S ^a   Aoyama, A ^a   Boskovic, S ^a   Nadazdin, O ^a   Capetta, K ^a   Smith, R N ^a   Colvin, R B ^a   Sachs, D H ^a   Cosimi, A B ^a   Kawai, T ^a   Madsen, J C ^a   Benichou, G ^a   Allan, J S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Animal models; basic (laboratory) research science; lung transplantation pulmonology; nonhuman primate; tolerance; translational research science

Indexed keywords

ALLOANTIBODY; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MEPREDNISONE; MYCOPHENOLATE MOFETIL; TACROLIMUS; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3;

ACUTE GRAFT REJECTION; ALLOGRAFT; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; AUTOPSY; CELL SELECTION; CHIMERA; GRAFT RECIPIENT; GRAFT SURVIVAL; IN VITRO STUDY; LEUKOCYTE; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; MACACA FASCICULARIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MIXED HEMATOPOIETIC CHIMERISM; NONHUMAN; NONMYELOABLATIVE CONDITIONING; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; ALLOTRANSPLANTATION; ANIMAL; HEMATOPOIESIS;

ANIMALS; CHIMERISM; HEMATOPOIESIS; LUNG TRANSPLANTATION; MACACA FASCICULARIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84937526651     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13274     Document Type: Article

References (29)

1. Sykes M, Sachs DH., Mixed allogeneic chimerism as an approach to transplantation tolerance. Immunol Today 1988; 9: 23-27.
2. Tomita Y, Khan A, Sykes M., Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen. J Immunol 1994; 153: 1087-1098.
3. Kawai T, Sogawa H, Boskovic S, et al., CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant 2004; 4: 1391-1398.
4. Ochiai T, Benichou G, Cosimi AB, Kawai T., Induction of allograft tolerance in nonhuman primates and humans. Front Biosci 2007; 12: 4248-4253.
5. Kawai T, Cosimi AB, Spitzer TR, et al., HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358: 353-361.
6. Murakami T, Cosimi AB, Kawai T., Mixed chimerism to induce tolerance: Lessons learned from nonhuman primates. Transplant Rev 2009; 23: 19-24.
7. Nadazdin O, Boskovic S, Murakami T, et al., Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med 2011; 3: 86ra51.
8. Nadazdin O, Boskovic S, Wee SL, et al., Contributions of direct and indirect alloresponses to chronic rejection of kidneyallografts in nonhuman primates. J Immunol 2011; 187: 4589-4597.
9. Lakkis FG, Sayegh MH., Memory T cells: A hurdle to immunologic tolerance. J Am Soc Nephrol 2003; 14: 2402-2410.
10. Valujskikh A., The challenge of inhibiting alloreactive T-cell memory. Am J Transplant 2006; 6: 647-651.
11. Lo DJ, Weaver TA, Stempora L, et al., Selective targeting of human alloresponsive CD8(+) effector memory T cells based on CD2 expression. Am J Transplant 2011; 11: 22-33.
12. Koyama I, Nadazdin O, Boskovic S, et al., Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant 2007; 7: 1055-1061.
13. Yamada Y, Boskovic S, Aoyama A, et al., Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant 2012; 12: 330-340.
14. Yamada Y, Benichou G, Cosimi AB, Kawai T., Tolerance induction after organ transplantation, "delayed tolerance," via the mixed chimerism approach: Planting flowers in a battle field. Chimerism 2012; 3: 24-28.
15. Lee S, Yamada Y, Tonsho M, et al., Alefacept promotes immunosuppression-free renal allograft survival in nonhuman primates via depletion of recipient memory T cells. Am J Transplant 2013; 13: 3223-3229.
16. O'Connor SL, Blasky AJ, Pendley CJ, et al., Comprehensive characterization of MHC class II haplotypes in Mauritian cynomolgus macaques. Immunogenetics 2007; 59: 449-462.
17. Pendley CJ, Becker EA, Karl JA, et al., MHC class I characterization of Indonesian cynomolgus macaques. Immunogenetics 2008; 60: 339-351.
18. Aoyama A, Tonsho M, Ng CY, et al., Long-term lung transplantation in nonhuman primates. Am J Transplant 2015; doi: 10.1111/ajt.13130.
19. Nadazdin O, Boskovic S, Murakami T, et al., Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. Am J Transplant 2010; 10: 1375-1384.
20. Boskovic S, Kawai T, Smith RN, et al., Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates. Transplantation 2006; 82: 819-825.
21. Benichou G, Valujskikh A, Heeger PS., Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice. J Immunol 1999; 162: 352-358.
22. Baker RJ, Hernandez-Fuentes MP, Brookes PA, Chaudhry AN, Cook HT, Lechler RI., Loss of direct and maintenance of indirect alloresponses in renal allograft recipients: Implications for the pathogenesis of chronic allograft nephropathy. J Immunol 2001; 167: 7199-7206.
23. Yamada A, Laufer TM, Gerth AJ, et al., Further analysis of the T-cell subsets and pathways of murine cardiac allograft rejection. Am J Transplant 2003; 3: 23-27.
24. Smith RN, Kawai T, Boskovic S, et al., Chronic antibody mediated rejection of renal allografts: Pathological, serological and immunologic features in nonhuman primates. Am J Transplant 2006; 6: 1790-1798.
25. Lee RS, Yamada K, Houser SL, et al., Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy. Proc Natl Acad Sci U S A 2001; 98: 3276-3281.
26. Adams AB, Williams MA, Jones TR, et al., Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003; 111: 1887-1895.
27. Bingaman AW, Farber DL., Memory T cells in transplantation: Generation, function, and potential role in rejection. Am J Transplant 2004; 4: 846-852.
28. Levesque V, Bardwell PD, Shimizu I, et al., B-cell-dependent memory T cells impede nonmyeloablative mixed chimerism induction in presensitized mice. Am J Transplant 2011; 11: 2322-2331.
29. LeGuern C., Potential role of major histocompatibility complex class II peptides in regulatory tolerance to vascularized grafts. Transplantation 2004; 77 (1 Suppl): S35-S37.