Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates

Science Translational Medicine

Volumn 3, Issue 86, 2011, Pages

  Nadazdin, Ognjenka ^a   Boskovic, Svjetlan ^a   Murakami, Toru ^a   Tocco, Georges ^a   Smith, Rex Neal ^a   Colvin, Robert B ^a   Sachs, David H ^a   Allan, James ^a   Madsen, Joren C ^a   Kawai, Tatsuo ^a   Cosimi, A Benedict ^a   Benichou, Gilles ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; CYCLOSPORIN A; GAMMA INTERFERON; KETOROLAC; RITUXIMAB; THYMOCYTE ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CONTROLLED STUDY; DONOR SELECTION; DRUG DOSE TITRATION; DRUG WITHDRAWAL; GRAFT RECIPIENT; GRAFT SURVIVAL; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; MEMORY T LYMPHOCYTE; MULTIPLE CYCLE TREATMENT; NONHUMAN; NONMYELOABLATIVE CONDITIONING; PRIMATE; PRIORITY JOURNAL; SHORT COURSE THERAPY; SURVIVAL RATE; THROMBOSIS; TRANSPLANTATION TOLERANCE; ANIMAL; BONE MARROW TRANSPLANTATION; FLOW CYTOMETRY; IMMUNOLOGICAL MEMORY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MACACA FASCICULARIS; T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; FLOW CYTOMETRY; GRAFT SURVIVAL; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; KIDNEY TRANSPLANTATION; MACACA FASCICULARIS; MALE; T-LYMPHOCYTES;

EID: 79958204678     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002093     Document Type: Article

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47. Funding: This work was supported by grants from the Massachusetts General Hospital Executive Committee on Research and National Institute of Allergy and Infectious Diseases grant U19 AI066705 to G.B., NIH grants 19 DK080652 and HL018446 to A.B.C., and NIH grants U191066705 and PO1HL18646 to J.C.M. Author contributions: All authors designed the study. O.N. and T.M. performed and analyzed most of the experiments, participated in their design, and analyzed the data. S.B., D.H.S., J.A., J.C.M., T.K., and A.B.C. performed the kidney transplantations and participated in the design of some of the experiments. R.B.C. and R.-N.S. performed histological evaluation of kidney transplants and provided critical suggestions and discussions. G.T. helped with statistical analyses, participated in the design of some of the experiments, and provided critical suggestions and discussions. G.B. conceived and supervised this study, was involved in the design and evaluation of all experiments, and wrote the manuscript with comments from coauthors. Competing interests: The authors declare that they have no competing interests.