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Volumn 8, Issue 6, 2015, Pages 1975-1986

One-step synthesis of fluorescent smart thermo-responsive copper clusters: A potential nanothermometer in living cells

Author keywords

cellular imaging; copper nanoclusters; fluorescence; nanothermometer

Indexed keywords


EID: 84937524025     PISSN: 19980124     EISSN: 19980000     Source Type: Journal    
DOI: 10.1007/s12274-015-0707-0     Document Type: Article
Times cited : (128)

References (57)
  • 1
    • 84857713943 scopus 로고    scopus 로고
    • Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopy
    • Okabe, K.; Inada, N.; Gota, C.; Harada, Y.; Funatsu, T.; Uchiyama, S. Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopy. Nat. Commun.2012, 3, 705–713.
    • (2012) Nat. Commun. , vol.3 , pp. 705-713
    • Okabe, K.1    Inada, N.2    Gota, C.3    Harada, Y.4    Funatsu, T.5    Uchiyama, S.6
  • 2
    • 84863921347 scopus 로고    scopus 로고
    • Luminescence nanothermometry
    • Jaque, D.; Vetrone, F. Luminescence nanothermometry. Nanoscale2012, 4, 4301–4326.
    • (2012) Nanoscale , vol.4 , pp. 4301-4326
    • Jaque, D.1    Vetrone, F.2
  • 3
    • 84876725181 scopus 로고    scopus 로고
    • Dualemitting nanoscale temperature sensors
    • McLaurin, E. J.; Bradshaw, L. R.; Gamelin, D. R. Dualemitting nanoscale temperature sensors. Chem. Mater.2013, 25, 1283–1292.
    • (2013) Chem. Mater. , vol.25 , pp. 1283-1292
    • McLaurin, E.J.1    Bradshaw, L.R.2    Gamelin, D.R.3
  • 5
    • 44849142363 scopus 로고    scopus 로고
    • Sensor paints
    • Wolfbeis, O. S. Sensor paints. Adv. Mater.2008, 20, 3759–3763.
    • (2008) Adv. Mater. , vol.20 , pp. 3759-3763
    • Wolfbeis, O.S.1
  • 6
    • 33846701633 scopus 로고    scopus 로고
    • Thermometer design at the nanoscale
    • Lee, J.; Kotov, N. A. Thermometer design at the nanoscale. Nano Today2007, 2, 48–51.
    • (2007) Nano Today , vol.2 , pp. 48-51
    • Lee, J.1    Kotov, N.A.2
  • 7
    • 33846009832 scopus 로고    scopus 로고
    • The historical development of temperature measurement in medicine
    • Ring, E. F. J. The historical development of temperature measurement in medicine. Infrared Phys. Technol.2007, 49, 297–301.
    • (2007) Infrared Phys. Technol. , vol.49 , pp. 297-301
    • Ring, E.F.J.1
  • 8
    • 48249104321 scopus 로고    scopus 로고
    • High-spatial-resolution surface-temperature mapping using fluorescent thermometry
    • Löw, P.; Kim, B.; Takama, N.; Bergaud, C. High-spatial-resolution surface-temperature mapping using fluorescent thermometry. Small2008, 4, 908–914.
    • (2008) Small , vol.4 , pp. 908-914
    • Löw, P.1    Kim, B.2    Takama, N.3    Bergaud, C.4
  • 9
    • 84859699247 scopus 로고    scopus 로고
    • Mapping intracellular temperature using green fluorescent protein
    • Donner, J. S.; Thompson, S. A.; Kreuzer, M. P.; Baffou, G.; Quidant, R. Mapping intracellular temperature using green fluorescent protein. Nano Lett.2012, 12, 2107–2111.
    • (2012) Nano Lett. , vol.12 , pp. 2107-2111
    • Donner, J.S.1    Thompson, S.A.2    Kreuzer, M.P.3    Baffou, G.4    Quidant, R.5
  • 11
    • 84862180031 scopus 로고    scopus 로고
    • Dual-emitting quantum dot/quantum rod-based nanothermometers with enhanced response and sensitivity in live cells
    • Albers, A. E.; Chan, E. M.; McBride, P. M.; Ajo-Franklin, C. M.; Cohen, B. E.; Helms, B. A. Dual-emitting quantum dot/quantum rod-based nanothermometers with enhanced response and sensitivity in live cells. J. Am. Chem. Soc.2012, 134, 9565–9568.
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 9565-9568
    • Albers, A.E.1    Chan, E.M.2    McBride, P.M.3    Ajo-Franklin, C.M.4    Cohen, B.E.5    Helms, B.A.6
  • 12
    • 77049115867 scopus 로고    scopus 로고
    • Luminescent europium(III) nanoparticles for sensing and imaging of temperature in the physiological range
    • Peng, H. S.; Stich, M. I. J.; Yu, J. B.; Sun, L. N.; Fischer, L. H.; Wolfbeis, O. S. Luminescent europium(III) nanoparticles for sensing and imaging of temperature in the physiological range. Adv. Mater.2010, 22, 716–719.
    • (2010) Adv. Mater. , vol.22 , pp. 716-719
    • Peng, H.S.1    Stich, M.I.J.2    Yu, J.B.3    Sun, L.N.4    Fischer, L.H.5    Wolfbeis, O.S.6
  • 13
    • 79955658702 scopus 로고    scopus 로고
    • Upconverting nanoparticles for nanoscale thermometry
    • Fischer, L. H.; Harms, G. S.; Wolfbeis, O. S. Upconverting nanoparticles for nanoscale thermometry. Angew. Chem. Int. Ed.2011, 50, 4546–4551.
    • (2011) Angew. Chem. Int. Ed. , vol.50 , pp. 4546-4551
    • Fischer, L.H.1    Harms, G.S.2    Wolfbeis, O.S.3
  • 14
    • 77950859284 scopus 로고    scopus 로고
    • Hydrophilic fluorescent nanogel thermometer for intracellular thermometry
    • Gota, C.; Okabe, K.; Funatsu, T.; Harada, Y.; Uchiyama, S. Hydrophilic fluorescent nanogel thermometer for intracellular thermometry. J. Am. Chem. Soc.2009, 131, 2766–2767.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 2766-2767
    • Gota, C.1    Okabe, K.2    Funatsu, T.3    Harada, Y.4    Uchiyama, S.5
  • 15
    • 35348968910 scopus 로고    scopus 로고
    • Structure of a thiol monolayer-protected gold nanoparticle at 1.1 Å resolution
    • Jadzinsky, P. D.; Calero, G.; Ackerson, C. J.; Bushnell, D. A.; Kornberg, R. D. Structure of a thiol monolayer-protected gold nanoparticle at 1.1 Å resolution. Science2007, 318, 430–433.
    • (2007) Science , vol.318 , pp. 430-433
    • Jadzinsky, P.D.1    Calero, G.2    Ackerson, C.J.3    Bushnell, D.A.4    Kornberg, R.D.5
  • 16
    • 84884837082 scopus 로고    scopus 로고
    • Substrate hydrolysis triggered formation of fluorescent gold nanoclusters—a new platform for the sensing of enzyme activity
    • Chen, Y.; Zhou, H. P.; Wang, Y.; Li, W. Y.; Chen, J.; Lin, Q.; Yu, C. Substrate hydrolysis triggered formation of fluorescent gold nanoclusters—a new platform for the sensing of enzyme activity. Chem. Commun.2013, 49, 9821–9823.
    • (2013) Chem. Commun. , vol.49 , pp. 9821-9823
    • Chen, Y.1    Zhou, H.P.2    Wang, Y.3    Li, W.Y.4    Chen, J.5    Lin, Q.6    Yu, C.7
  • 17
    • 79961222633 scopus 로고    scopus 로고
    • A simple reducing approach using amine to give dual functional EuSe nanocrystals and morphological tuning
    • Wang, C. X.; Zhang, D.; Xu, L.; Jiang, Y. N.; Dong, F. X.; Yang, B.; Yu, K.; Lin, Q. A simple reducing approach using amine to give dual functional EuSe nanocrystals and morphological tuning. Angew. Chem. Int. Ed.2011, 50, 7587–7591.
    • (2011) Angew. Chem. Int. Ed. , vol.50 , pp. 7587-7591
    • Wang, C.X.1    Zhang, D.2    Xu, L.3    Jiang, Y.N.4    Dong, F.X.5    Yang, B.6    Yu, K.7    Lin, Q.8
  • 18
    • 84890135203 scopus 로고    scopus 로고
    • Lighting up thiolated Au@Ag nanoclusters via aggregation-induced emission
    • Dou, X. Y.; Yuan, X.; Yu, Y.; Luo, Z. T.; Yao, Q. F.; Leong, D. T.; Xie, J. Lighting up thiolated Au@Ag nanoclusters via aggregation-induced emission. Nanoscale2014, 6, 157–161.
    • (2014) Nanoscale , vol.6 , pp. 157-161
    • Dou, X.Y.1    Yuan, X.2    Yu, Y.3    Luo, Z.T.4    Yao, Q.F.5    Leong, D.T.6    Xie, J.7
  • 19
    • 80051763980 scopus 로고    scopus 로고
    • Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications
    • Shang, L.; Dong, S. J.; Nienhaus, G. U. Ultra-small fluorescent metal nanoclusters: Synthesis and biological applications. Nano Today2011, 6, 401–418.
    • (2011) Nano Today , vol.6 , pp. 401-418
    • Shang, L.1    Dong, S.J.2    Nienhaus, G.U.3
  • 20
    • 84875764762 scopus 로고    scopus 로고
    • Passive tumor targeting of renal-clearable luminescent gold nanoparticles: Long tumor retention and fast normal tissue clearance
    • Liu, J. B.; Yu, M. X.; Zhou, C.; Yang, S. Y.; Ning X. H.; Zheng, J. Passive tumor targeting of renal-clearable luminescent gold nanoparticles: Long tumor retention and fast normal tissue clearance. J. Am. Chem. Soc.2013, 135, 4978–4981.
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 4978-4981
    • Liu, J.B.1    Yu, M.X.2    Zhou, C.3    Yang, S.Y.4    Ning, X.H.5    Zheng, J.6
  • 21
    • 84897023162 scopus 로고    scopus 로고
    • +-rich nanoclusters as highly efficient nanoreservoirs for bacterial killing
    • +-rich nanoclusters as highly efficient nanoreservoirs for bacterial killing. Nano Res.2014, 7, 301–307.
    • (2014) Nano Res. , vol.7 , pp. 301-307
    • Yuan, X.1    Setyawati, M.I.2    Leong, D.T.3    Xie, J.P.4
  • 22
    • 84892698443 scopus 로고    scopus 로고
    • Facile preparation of fluorescent Agclusters-chitosan-hybrid nanocomposites for bio-applications
    • Wang, C.; Huang, Y. Facile preparation of fluorescent Agclusters-chitosan-hybrid nanocomposites for bio-applications. New J. Chem.2014, 38, 657–662.
    • (2014) New J. Chem. , vol.38 , pp. 657-662
    • Wang, C.1    Huang, Y.2
  • 23
    • 84892634198 scopus 로고    scopus 로고
    • Protein-directed synthesis of pH-responsive red fluorescent copper nanoclusters and their applications in cellular imaging and catalysis
    • Wang, C.; Wang, C. X.; Xu, L.; Cheng, H.; Lin, Q.; Zhang, C. Protein-directed synthesis of pH-responsive red fluorescent copper nanoclusters and their applications in cellular imaging and catalysis. Nanocale2014, 6, 1775–1781.
    • (2014) Nanocale , vol.6 , pp. 1775-1781
    • Wang, C.1    Wang, C.X.2    Xu, L.3    Cheng, H.4    Lin, Q.5    Zhang, C.6
  • 24
    • 84889046560 scopus 로고    scopus 로고
    • Stable Cu nanoclusters: From an aggregation induced emission mechanism to biosensing and catalytic applications
    • Jia, X. F.; Yuan, X.; Li, J.; Li, D. Y.; Wang, E. Stable Cu nanoclusters: From an aggregation induced emission mechanism to biosensing and catalytic applications. Chem. Commun.2014, 50, 237–239.
    • (2014) Chem. Commun. , vol.50 , pp. 237-239
    • Jia, X.F.1    Yuan, X.2    Li, J.3    Li, D.Y.4    Wang, E.5
  • 27
    • 81855227349 scopus 로고    scopus 로고
    • Synthesis of highly fluorescent metal (Ag, Au, Pt, and Cu) nanoclusters by electrostatically induced reversible phase transfer
    • Yuan, X.; Luo, Z. T.; Zhang, Q. B.; Zhang, X. H.; Zheng, Y. G.; Lee, J. Y.; Xie, J. P. Synthesis of highly fluorescent metal (Ag, Au, Pt, and Cu) nanoclusters by electrostatically induced reversible phase transfer. ACS Nano2011, 5, 8800–8808.
    • (2011) ACS Nano , vol.5 , pp. 8800-8808
    • Yuan, X.1    Luo, Z.T.2    Zhang, Q.B.3    Zhang, X.H.4    Zheng, Y.G.5    Lee, J.Y.6    Xie, J.P.7
  • 28
    • 77954304731 scopus 로고    scopus 로고
    • Mercaptosilane-assisted synthesis of metal clusters within zeolites and catalytic consequences of encapsulation
    • Choi, M.; Wu, Z.; Iglesia, E. Mercaptosilane-assisted synthesis of metal clusters within zeolites and catalytic consequences of encapsulation. J. Am. Chem. Soc.2010, 132, 9129–9137.
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 9129-9137
    • Choi, M.1    Wu, Z.2    Iglesia, E.3
  • 29
    • 83455181359 scopus 로고    scopus 로고
    • Photoreductive synthesis of water-soluble fluorescent metal nanoclusters
    • Zhang H.; Huang, X.; Li, L.; Zhang, G. W.; Hussain, I.; Li, Z.; Tan, B. Photoreductive synthesis of water-soluble fluorescent metal nanoclusters. Chem. Commun.2011, 48, 567–569.
    • (2011) Chem. Commun. , vol.48 , pp. 567-569
    • Zhang, H.1    Huang, X.2    Li, L.3    Zhang, G.W.4    Hussain, I.5    Li, Z.6    Tan, B.7
  • 30
    • 84883866742 scopus 로고    scopus 로고
    • Glutathione-capped fluorescent gold nanoclusters for dual-modal fluorescence/X-ray computed tomography imaging
    • Zhang, C. L.; Zhou, Z. J.; Qian, Q. R.; Gao, G.; Li, C.; Feng, L. L.; Wang, Q.; Cui, D. X. Glutathione-capped fluorescent gold nanoclusters for dual-modal fluorescence/X-ray computed tomography imaging. J. Mater. Chem. B2013, 1, 5045–5053.
    • (2013) J. Mater. Chem. B , vol.1 , pp. 5045-5053
    • Zhang, C.L.1    Zhou, Z.J.2    Qian, Q.R.3    Gao, G.4    Li, C.5    Feng, L.L.6    Wang, Q.7    Cui, D.X.8
  • 31
    • 84882994170 scopus 로고    scopus 로고
    • Green route to prepare biocompatible and near infrared thiolate-protected copper nanoclusters for cellular imaging
    • Wang, C.; Huang, Y. Green route to prepare biocompatible and near infrared thiolate-protected copper nanoclusters for cellular imaging. Nano2013, 8, 1350054.
    • (2013) Nano , vol.8 , pp. 1350054
    • Wang, C.1    Huang, Y.2
  • 32
    • 77957155447 scopus 로고    scopus 로고
    • Glutathione-stabilized magic-number silver cluster compounds
    • Kumar, S.; Bolan, M. D.; Bigioni, T. P. Glutathione-stabilized magic-number silver cluster compounds. J. Am. Chem. Soc.2010, 132, 13141–13143.
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 13141-13143
    • Kumar, S.1    Bolan, M.D.2    Bigioni, T.P.3
  • 34
    • 84896500091 scopus 로고    scopus 로고
    • Engineering ultrasmall water-soluble gold and silver nanoclusters for biomedical applications
    • Luo, Z. T.; Zheng K. Y.; Xie, J. P. Engineering ultrasmall water-soluble gold and silver nanoclusters for biomedical applications. Chem. Comm.2014, 50, 5143–5155.
    • (2014) Chem. Comm. , vol.50 , pp. 5143-5155
    • Luo, Z.T.1    Zheng, K.Y.2    Xie, J.P.3
  • 35
    • 84881240565 scopus 로고    scopus 로고
    • A dualemission fluorescent nanocomplex of gold-cluster-decorated silica particles for live cell imaging of highly reactive oxygen species
    • Chen, T. T.; Hu, Y. H.; Cen, Y.; Chu, X.; Lu, Y. A dualemission fluorescent nanocomplex of gold-cluster-decorated silica particles for live cell imaging of highly reactive oxygen species. J. Am. Chem. Soc.2013, 135, 11595–11602.
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 11595-11602
    • Chen, T.T.1    Hu, Y.H.2    Cen, Y.3    Chu, X.4    Lu, Y.5
  • 37
    • 84867360164 scopus 로고    scopus 로고
    • From aggregation-induced emission of Au(I)-thiolate complexes to ultrabright Au(0)@Au(I)-thiolate core-shell nanoclusters
    • Luo, Z. T.; Yuan, X.; Yu, Y.; Zhang, Q. B.; Leong, D. T.; Lee, J. Y.; Xie, J. P. From aggregation-induced emission of Au(I)-thiolate complexes to ultrabright Au(0)@Au(I)-thiolate core-shell nanoclusters. J. Am. Chem. Soc.2012, 134, 16662–16670.
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 16662-16670
    • Luo, Z.T.1    Yuan, X.2    Yu, Y.3    Zhang, Q.B.4    Leong, D.T.5    Lee, J.Y.6    Xie, J.P.7
  • 38
    • 84862541342 scopus 로고    scopus 로고
    • 8 clusters: Synthesis mechanism and application for sensing of glutathione in a single drop of blood
    • 8 clusters: Synthesis mechanism and application for sensing of glutathione in a single drop of blood. Small2012, 8, 1912–1919.
    • (2012) Small , vol.8 , pp. 1912-1919
    • Chen, T.H.1    Tseng, W.L.2
  • 40
    • 84862572461 scopus 로고    scopus 로고
    • Fluorescent silver nanoclusters as effective probes for highly selective detection of mercury(II) at parts-per-billion levels
    • Wang, C. X.; Xu, L.; Wang, Y.; Zhang, D.; Shi, X. D.; Dong, F. X.; Yu, K.; Lin, Q.; Yang, B. Fluorescent silver nanoclusters as effective probes for highly selective detection of mercury(II) at parts-per-billion levels. Chem. Asian J.2012, 7, 1652–1656.
    • (2012) Chem. Asian J. , vol.7 , pp. 1652-1656
    • Wang, C.X.1    Xu, L.2    Wang, Y.3    Zhang, D.4    Shi, X.D.5    Dong, F.X.6    Yu, K.7    Lin, Q.8    Yang, B.9
  • 41
    • 84863272903 scopus 로고    scopus 로고
    • Developing a millifluidic platform for the synthesis of ultrasmall nanoclusters: Ultrasmall copper nanoclusters as a case study
    • Biswas, S.; Miller, J. T.; Li, Y. H.; Nandakumar, K.; Kumar, C. S. S. R. Developing a millifluidic platform for the synthesis of ultrasmall nanoclusters: Ultrasmall copper nanoclusters as a case study. Small2012, 8, 688–698.
    • (2012) Small , vol.8 , pp. 688-698
    • Biswas, S.1    Miller, J.T.2    Li, Y.H.3    Nandakumar, K.4    Kumar, C.S.S.R.5
  • 42
    • 0037816096 scopus 로고    scopus 로고
    • Preparation of Cu nanoclusters within dendrimer templates
    • Zhao, M. Q.; Sun, L.; Crooks, R. M. Preparation of Cu nanoclusters within dendrimer templates. J. Am. Chem. Soc.1998, 120, 4877–4878.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 4877-4878
    • Zhao, M.Q.1    Sun, L.2    Crooks, R.M.3
  • 43
    • 66749167686 scopus 로고    scopus 로고
    • Ultrasmall copper nanoparticles from a hydrophobically immobilized surfactant template
    • Brege, J. J.; Hamilton, C. E.; Crouse, C. A.; Barron, A. R. Ultrasmall copper nanoparticles from a hydrophobically immobilized surfactant template. Nano Lett.2009, 9, 2239–2242.
    • (2009) Nano Lett. , vol.9 , pp. 2239-2242
    • Brege, J.J.1    Hamilton, C.E.2    Crouse, C.A.3    Barron, A.R.4
  • 45
    • 79951825511 scopus 로고    scopus 로고
    • One-pot synthesis, photoluminescence, and electrocatalytic properties of subnanometer-sized copper clusters
    • Wei, W. T.; Lu, Y. Z.; Chen, W.; Chen, S. W. One-pot synthesis, photoluminescence, and electrocatalytic properties of subnanometer-sized copper clusters. J. Am. Chem. Soc.2011,133, 2060–2063.
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 2060-2063
    • Wei, W.T.1    Lu, Y.Z.2    Chen, W.3    Chen, S.W.4
  • 47
    • 84873381449 scopus 로고    scopus 로고
    • A galvanic replacement route to prepare strongly fluorescent and highly stable gold nanodots for cellular imaging
    • Wang, C. X.; Wang, Y.; Xu, L.; Shi, X. D.; Li, X. W.; Xu, X. W.; Sun, H. C.; Yang, B.; Lin, Q. A galvanic replacement route to prepare strongly fluorescent and highly stable gold nanodots for cellular imaging. Small2013, 9, 413–420.
    • (2013) Small , vol.9 , pp. 413-420
    • Wang, C.X.1    Wang, Y.2    Xu, L.3    Shi, X.D.4    Li, X.W.5    Xu, X.W.6    Sun, H.C.7    Yang, B.8    Lin, Q.9
  • 49
    • 84912096455 scopus 로고    scopus 로고
    • Recent advances in the synthesis,^characterization,^and biomedical applications of ultrasmall thiolated silver nanoclusters
    • Zheng, K. Y.; Yuan, X.; Goswami, N.; Zhang, Q. B.; Xie, J. P. Recent advances in the synthesis, characterization, and biomedical applications of ultrasmall thiolated silver nanoclusters. RSC Advances2014, 4, 60581–60596.
    • (2014) RSC Advances , vol.4 , pp. 60581-60596
    • Zheng, K.Y.1    Yuan, X.2    Goswami, N.3    Zhang, Q.B.4    Xie, J.P.5
  • 52
    • 84887465105 scopus 로고    scopus 로고
    • Cu nanoclusters with aggregation induced emission enhancement
    • Jia, X. F.; Li, J.; Wang, E. K. Cu nanoclusters with aggregation induced emission enhancement. Small2013, 9, 3873–3879.
    • (2013) Small , vol.9 , pp. 3873-3879
    • Jia, X.F.1    Li, J.2    Wang, E.K.3
  • 53
    • 33644546388 scopus 로고    scopus 로고
    • Dual-responsive surfaces that switch between superhydrophilicity and superhydrophobicity
    • Xia, F.; Feng, L.; Wang, S. T.; Sun, T. L.; Song, W. L.; Jiang, W. H.; Jiang, L. Dual-responsive surfaces that switch between superhydrophilicity and superhydrophobicity. Adv. Mater.2006, 18, 432–436.
    • (2006) Adv. Mater. , vol.18 , pp. 432-436
    • Xia, F.1    Feng, L.2    Wang, S.T.3    Sun, T.L.4    Song, W.L.5    Jiang, W.H.6    Jiang, L.7
  • 55
    • 0037206723 scopus 로고    scopus 로고
    • Nanoparticle luminescence thermometry
    • Wang, S. P.; Westcott, S.; Chen, W. Nanoparticle luminescence thermometry. J. Phys. Chem. B2002, 106, 11203–11209.
    • (2002) J. Phys. Chem. B , vol.106 , pp. 11203-11209
    • Wang, S.P.1    Westcott, S.2    Chen, W.3


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