Blockade of Extracellular HMGB1 Suppresses Xenoreactive B Cell Responses and Delays Acute Vascular Xenogeneic Rejection

American Journal of Transplantation

Volumn 15, Issue 8, 2015, Pages 2062-2074

  Li, J H ^a   Zhao, B ^a   Zhu, X H ^a   Wang, L ^a   Zou, H J ^b   Chen, S ^a,c,d   Guo, H ^a,c,d   Ruan, Y L ^a   Zheng, F ^b,c,d   Xiang, Y ^a,c,d   Ming, C S ^a,c,d   Gong, F L ^b,c,d   Chen, G ^a,c,d  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d BEIJING HOSPITAL   (China)

Author keywords

Animal models: murine; basic (laboratory) research science, heart transplantation cardiology; immunobiology; innate immunity; rejection: vascular; xenoantibody; xenotransplantation

Indexed keywords

CD19 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 6; MESSENGER RNA; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 4; HMGB1 PROTEIN, HUMAN;

ACUTE VASCULAR REJECTION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL DAMAGE; CELL INFILTRATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; CYTOPLASM VESICLE; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; EXTRACELLULAR SPACE; GRAFT SURVIVAL; HEART MUSCLE CELL; HEART TRANSPLANTATION; IMMUNE RESPONSE; LYMPHOCYTIC INFILTRATION; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPLEEN CELL; UPREGULATION; XENOTRANSPLANTATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; GRAFT REJECTION; IMMUNOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; B-LYMPHOCYTES; GRAFT REJECTION; HMGB1 PROTEIN; MALE; MICE; MICE, INBRED BALB C; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84937519817     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13275     Document Type: Article

References (23)

1. Land WG., Emerging role of innate immunity in organ transplantation: Part I: Evolution of innate immunity and oxidative allograft injury. Transplant Rev (Orlando, FL) 2012; 26: 60-72.
2. Huang Y, Yin H, Han J, et al., Extracellular hmgb1 functions as an innate immune-mediator implicated in murine cardiac allograft acute rejection. Am J Transplant 2007; 7: 799-808.
3. Land WG., Emerging role of innate immunity in organ transplantation part II: Potential of damage-associated molecular patterns to generate immunostimulatory dendritic cells. Transplant Rev (Orlando, FL) 2012; 26: 73-87.
4. LaRosa DF, Rahman AH, Turka LA., The innate immune system in allograft rejection and tolerance. J Immunol 2007; 178: 7503-7509.
5. Manfredi AA, Capobianco A, Bianchi ME, Rovere-Querini P., Regulation of dendritic- and T-cell fate by injury-associated endogenous signals. Crit Rev Immunol 2009; 29: 69-86.
6. Jurewicz M, Takakura A, Augello A, et al., Ischemic injury enhances dendritic cell immunogenicity via TLR4 and NF-kappa B activation. J Immunol 2010; 184: 2939-2948.
7. Mori DN, Kreisel D, Fullerton JN, Gilroy DW, Goldstein DR,. Inflammatory triggers of acute rejection of organ allografts. Immunol Rev 2014; 258: 132-144.
8. Javaherian K, Liu JF, Wang JC., Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science 1978; 199: 1345-1346.
9. Bustin M, Hopkins RB, Isenberg I., Immunological relatedness of high mobility group chromosomal proteins from calf thymus. J Biol Chem 1978; 253: 1694-1699.
10. Park JS, Svetkauskaite D, He Q, et al., Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004; 279: 7370-7377.
11. Hori O, Brett J, Slattery T, et al., The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem 1995; 270: 25752-25761.
12. Duan L, Wang CY, Chen J, et al., High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response. Lab Invest 2011; 91: 43-53.
13. Moser B, Szabolcs MJ, Ankersmit HJ, et al., Blockade of RAGE suppresses alloimmune reactions in vitro and delays allograft rejection in murine heart transplantation. Am J Transplant 2007; 7: 293-302.
14. Wang H, DeVries ME, Deng S, et al., The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nat Med 2000; 6: 549-555.
15. Wang H, Hosiawa KA, Min W, et al., Cytokines regulate the pattern of rejection and susceptibility to cyclosporine therapy in different mouse recipient strains after cardiac allografting. J Immunol 2003; 171: 3823-3836.
16. Li J, Gong Q, Zhong S, et al., Neutralization of the extracellular HMGB1 released by ischaemic damaged renal cells protects against renal ischaemia-reperfusion injury. Nephrol Dial Transplant 2011; 26: 469-478.
17. Chen ZH., A technique of cervical heterotopic heart transplantation in mice. Transplantation 1991; 52: 1099-1101.
18. Dumitriu IE, Baruah P, Manfredi AA, Bianchi ME, Rovere-Querini P., HMGB1: Guiding immunity from within. Trends Immunol 2005; 26: 381-387.
19. Kazama H, Ricci JE, Herndon JM, Hoppe G, Green DR, Ferguson TA., Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 2008; 29: 21-32.
20. Andrassy M, Volz HC, Igwe JC, et al., High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008; 117: 3216-3226.
21. Tsung A, Sahai R, Tanaka H, et al., The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005; 201: 1135-1143.
22. Wu H, Ma J, Wang P, et al., HMGB1 contributes to kidney ischemia reperfusion injury. J Am Soc Nephrol 2010; 21: 1878-1890.
23. Plenter RJ, Grazia TJ, Doan AN, Gill RG, Pietra BA., CD4 T cells mediate cardiac xenograft rejection via host MHC Class II. J Heart Lung Transplant 2012; 31: 1018-1024.