CD4 T cells mediate cardiac xenograft rejection via host MHC Class II

Journal of Heart and Lung Transplantation

Volumn 31, Issue 9, 2012, Pages 1018-1024

  Plenter, Robert J ^a   Grazia, Todd J ^a   Doan, An N ^a   Gill, Ronald G ^a   Pietra, Biagio A ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

antigen presentation processing; MHC; T cell; transplantation

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CELL STIMULATION; CELL TRANSFER; CONTROLLED STUDY; GRAFT SURVIVAL; HEART; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; RATS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84864919029     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2012.05.018     Document Type: Article

References (49)

1. A.G. Rose Understanding the pathogenesis and the pathology of hyperacute cardiac rejection Cardiovasc Pathol 11 2002 171 176
2. D.K. Cooper, A.M. Keogh, J. Brink Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases J Heart Lung Transplant 19 2000 1125 1165
3. C. Knosalla, J. Muller, K. Moran Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation J Heart Lung Transplant 23 2004 623 626
4. G.V. Gonzalez-Stawinski, R.D. Davis Jr Rituximab as monotherapy for elicited xenoreactive antibody responses J Heart Lung Transplant 25 2006 1462 1466
5. C.G. McGregor, W.R. Davies, K. Oi Cardiac xenotransplantation: recent preclinical progress with 3-month median survival J Thorac Cardiovasc Surg 130 2005 844 851
6. G.R. Rayat, R.G. Gill Pancreatic islet xenotransplantation: barriers and prospects Curr Diab Rep 3 2003 336 343
7. K. Ogata, J. Platt Potential applications and prospects for cardiac xenotransplantation J Heart Lung Transplant 23 2004 515 526
8. T. Friedman, R.N. Smith, R.B. Colvin A critical role for human CD4+ T-cells in rejection of porcine islet cell xenografts Diabetes 48 1999 2340 2348
9. R.G. Gill CD4+ T cells are both necessary and sufficient for islet xenograft rejection Transplant Proc 26 1994 1203
10. B.J. Olack Rejection of porcine islet xenografts mediated by CD4+ T cells activated through the indirect antigen recognition pathway Xenotransplantation 9 2002 393 401
11. H. Wecker, H. Winn, H.J. Auchincloss CD4+ T cells, without CD8+ or B lymphocytes, can reject xenogeneic skin grafts Xenotransplantation 1994 8 16
12. L.A. Wolf, M. Coulombe, R.G. Gill Donor antigen-presenting cell-independent rejection of islet xenografts Transplantation 60 1995 1164 1170
13. Y. Zhao The critical role of mouse CD4+ cells in the rejection of highly disparate xenogeneic pig thymus grafts Xenotransplantation 7 2000 129 137
14. G.R. Rayat The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection Diabetes 52 2003 1433 1440
15. R.G. Gill The role of direct and indirect antigen presentation in the response to islet xenografts Transplant Proc 24 1992 642 643
16. H. Auchincloss Jr, R. Moses, D. Conti Xenograft rejection of class I-expressing transgenic skin is CD4-dependent and CD8-independent Transplant Proc 22 1990 2335 2336
17. B. Murphy, H. Auchincloss Jr, C.B. Carpenter T cell recognition of xeno-MHC peptides during concordant xenograft rejection Transplantation 61 1996 1133 1137
18. K.F. Lindahl, F.H. Bach Genetic and cellular aspects of xenogeneic mixed leukocyte culture reaction J Exp Med 144 1976 305 318
19. B.J. Alter, F.H. Bach Cellular basis of the proliferative response of human T cells to mouse xenoantigens J Exp Med 171 1990 333 338
20. P.G. Stock, N.L. Ascher, S. Chen Evidence for direct and indirect pathways in the generation of the alloimmune response against pancreatic islets Transplantation 52 1991 704 709
21. H. Auchincloss Jr, D.H. Sachs Xenogeneic transplantation Annu Rev Immunol 16 1998 433 470
22. H. Auchincloss Jr Cell-mediated xenoresponses: strong or weak? Clin Transplant 8 1994 155 159
23. C.A. Bravery Direct recognition of SLA- and HLA-like class II antigens on porcine endothelium by human T cells results in T cell activation and release of interleukin-2 Transplantation 60 1995 1024 1033
24. A. Dorling Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population Eur J Immunol 26 1996 1378 1387
25. A.D. Kirk The human antiporcine cellular repertoire In vitro studies of acquired and innate cellular responsiveness Transplantation 55 1993 924 931
26. S.A. Rollins Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2 Transplantation 57 1994 1709 1716
27. K. Yamada, D.H. Sachs, H. DerSimonian Human anti-porcine xenogeneic T cell response Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition J Immunol 155 1995 5249 5256
28. N.P. Singh Blockade of indirect recognition mediated by CD4+ T cells leads to prolonged cardiac xenograft survival Xenotransplantation 11 2004 33 42
29. T.J. Grazia A two-step model of acute CD4 T-cell mediated cardiac allograft rejection J Immunol 172 2004 7451 7458
30. B.A. Pietra CD4 T cell-mediated cardiac allograft rejection requires donor but not host MHC class II J Clin Invest 106 2000 1003 1010
31. R.J. Corry, H.J. Winn, P.S. Russell Primarily vascularized allografts of hearts in mice The role of H-2D, H-2K, and non-H-2 antigens in rejection Transplantation 16 1973 343 350
32. D.B. Wilde Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines J Immunol 131 1983 2178 2183
33. M. Sarmiento Cloned T lymphocytes and monoclonal antibodies as probes for cell surface molecules active in T cell-mediated cytolysis Immunol Rev 68 1982 135 169
34. M.J. Grusby Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice Science 253 1991 1417 1420
35. S. Yi CD4+ T cells initiate pancreatic islet xenograft rejection via an interferon-gamma-dependent recruitment of macrophages and natural killer cells Transplantation 73 2002 437 446
36. S. Harrison An efficient method for producing alpha(1,3)- galactosyltransferase gene knockout pigs Cloning Stem Cells 6 2004 327 331
37. C.Y. Zhou Transgenic pigs expressing human CD59, in combination with human membrane cofactor protein and human decay-accelerating factor Xenotransplantation 12 2005 142 148
38. X. Zhu, F.J. Dor, D.K. Cooper Pig-to-non-human primate heart transplantation: immunologic progress over 20 years J Heart Lung Transplant 26 2007 210 218
39. A. De Creus, K. van Beneden, T. Taghon Langerhans cells that have matured in vivo in the absence of T cells are fully capable of inducing a helper CD4 as well as a cytotoxic CD8 response J Immunol 165 2000 645 653
40. V. Shreedhar, A.M. Moodycliffe, S.E. Ullrich Dendritic cells require T cells for functional maturation in vivo Immunity 11 1999 625 636
41. A. Andres Macrophage depletion prolongs discordant but not concordant islet xenograft survival Transplantation 79 2005 543 549
42. S. Itescu Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period Hum Immunol 59 1998 275 286
43. P. Schmidt A new murine model of islet xenograft rejection: graft destruction is dependent on a major histocompatibility-specific interaction between T-cells and macrophages Diabetes 52 2003 1111 1118
44. T.M. Kupfer, M.L. Crawford, K. Pham MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo J Immunol 175 2005 2309 2316
45. E. Angstetra, K.L. Graham, S. Emmett In vivo effects of cytokines on pancreatic beta-cells in models of type 1 diabetes dependent on CD4+ T lymphocytes Immunol Cell Biol 87 2009 178 185
46. P.S. Heeger, C. Kemper Novel roles of complement in T effector cell regulation Immunobiology 217 2012 216 224
47. A.B. Adams, M.A. Williams, T.R. Jones Heterologous immunity provides a potent barrier to transplantation tolerance J Clin Invest 111 2003 1887 1895
48. L.J. Daniels, J.L. Platt Hyperacute xenograft rejection as an immunologic barrier to xenotransplantation Kidney Int 58 suppl 1997 S28 S35
49. I.F. McKenzie Pig islet xenografts are susceptible to "anti-pig" but not Gal alpha(1,3)Gal antibody plus complement in Gal o/o mice J Immunol 161 1998 5116 5119