Study of permeation and blocker binding in TMEM16A calcium-activated chloride channels

Channels

Volumn 9, Issue 2, 2015, Pages 88-95

  Reyes, J P ^a   Huanosta Gutierrez A ^a   Lopez Rodriguez A ^b   Martinez Torres A ^a  

^a CENTRO DE FÍSICA APLICADA Y TECNOLOGÍA AVANZADA   (Mexico)

^b UNIVERSIDAD JUÁREZ DEL ESTADO DE DURANGO   (Mexico)

Author keywords

2 stilbenedisulfonic acid; 4; 4 Diisothiocyano 2; Anthracene 9 carboxylic acid; Calcium activated chloride channels; DIDS; Ion permeation; Pore; Pore blockers; TMEM16A; Xenopus tropicalis A 9 C

Indexed keywords

4, 4' DIISOTHIOCYANATOSTILBENE 2, 2' DISULFONIC ACID; 9 ANTHROIC ACID; ANION; CALCIUM ACTIVATED CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; MEMBRANE PROTEIN; SODIUM; T16INH A01; TRANSMEMBRANE MEMBER 16A; UNCLASSIFIED DRUG; CHLORIDE CHANNEL; CHLORIDE CHANNEL STIMULATING AGENT; TMEM16A PROTEIN, XENOPUS; XENOPUS PROTEIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE MUTATION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; REVERSAL POTENTIAL; XENOPUS TROPICALIS; AGONISTS; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; PERMEABILITY;

BINDING SITES; CHLORIDE CHANNEL AGONISTS; CHLORIDE CHANNELS; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PERMEABILITY; XENOPUS PROTEINS;

EID: 84937514369     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.1080/19336950.2015.1027849     Document Type: Article

References (17)

1. Pedemonte N, Galietta LJ. Structure and function of TMEM16 proteins (anoctamins). Physiol Rev 2014; 94:419–59; PMID:24692353; http://dx.doi.org/10.1152/physrev.00039.2011
2. Huang F, Wong X, Jan LY. International union of basic and clinical pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol Rev 2012; 64:1–15; PMID:22090471; http://dx.doi.org/10.1124/pr.111.005009
3. Malvezzi M, Chalat M, Janjusevic R, Picollo A, Terashima H, Menon AK, Accardi A. Ca2C-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel. Nat Commun 2013; 4:2367; PMID:23996062; http://dx.doi.org/10.1038/ncomms3367
4. Terashima H, Picollo A, Accardi A. Purified TMEM16A is sufficient to form Ca2+-activated Clchannels. Proc Natl Acad Sci U S A 2014; 110:19354–9; http://dx.doi.org/10.1073/pnas.1312014110
5. Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler R. Xray structure of a calcium-activated TMEM16 lipid scramblase. Nature 2014; 516:207–12; PMID:25383531; http://dx.doi.org/10.1038/nature13984
6. Reyes JP, Lopez-Rodriguez A, Espino-Saldana AE, Huanosta-Gutierrez A, Miledi R, Martinez-Torres A. Anion permeation in calcium-activated chloride channels formed by TMEM16A from Xenopus tropicalis. Pflugers Arch 2014; 466:1769–77; PMID:24352628; http://dx.doi.org/10.1007/s00424-013-1415-9
7. Bezanilla F. Ion channels: from conductance to structure. Neuron 2008; 60:456–68; PMID:18995820; http://dx.doi.org/10.1016/j.neuron.2008.10.035
8. Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 2008; 455:1210–5; PMID:18724360; http://dx.doi.org/10.1038/nature07313
9. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, et al. TMEM16F forms a Ca2C-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell 2012; 151:111–22; PMID:23021219; http://dx.doi.org/10.1016/j.cell.2012.07.036
10. Qu Z, Hartzell HC. Functional geometry of the permeation pathway of Ca2+-activated Cl-channels inferred from analysis of voltage-dependent block. J Biol Chem 2001; 276:18423–9; PMID:11279188; http://dx.doi.org/10.1074/jbc.M101264200
11. Qu Z, Hartzell HC. Anion permeation in Ca2+-activated Cl(-) channels. J Gen Physiol 2000; 116:825–44; PMID:11099350; http://dx.doi.org/10.1085/jgp.116.6.825
12. Betto G, Cherian OL, Pifferi S, Cenedese V, Boccaccio A, Menini A. Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel. J Gen Physiol 2014; 143:703–18; PMID:24863931; http://dx.doi.org/10.1085/jgp.201411182
13. Bradley E, Fedigan S, Webb T, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP. Pharmacological characterization of TMEM16A currents. Channels (Austin) 2014; 8:308–20; PMID:24642630; http://dx.doi.org/10.4161/chan.28065
14. Greenwood IA, Large WA. Modulation of the decay of Ca2+-activated Cl-currents in rabbit portal vein smooth muscle cells by external anions. J Physiol 1999; 516(Pt 2):365–76; PMID:10087337; http://dx.doi.org/10.1111/j.1469-7793.1999.0365v.x
15. Perez-Cornejo P, De Santiago JA, Arreola J. Permeant anions control gating of calcium-dependent chloride channels. J Membr Biol 2004; 198:125–33; PMID:15216414; http://dx.doi.org/10.1007/s00232-004-0659-x
16. Huanosta-Gutierrez A, Espino-Saldana AE, Reyes JP, Petriz A, Miledi R, Martinez-Torres A. TMEM16A alternative splicing isoforms in Xenopus tropicalis: distribution and functional properties. Biochem Biophys Res Commun 2014; 446:1096–101; PMID:24661876; http://dx.doi.org/10.1016/j.bbrc.2014.03.057
17. Woodhull AM. Ionic blockage of sodium channels in nerve. J Gen Physiol 1973; 61:687–708; PMID:4541078; http://dx.doi.org/10.1085/jgp.61.6.687