Toll-like receptor 4-induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma

Annals of Diagnostic Pathology

Volumn 19, Issue 4, 2015, Pages 232-238

  Wang, Xiaofang ^a   Li, Xiangli ^a   Zhang, Xiaoying ^a   Zang, Li ^a   Yang, Hongliang ^a   Zhao, Weipeng ^a   Zhao, Haifeng ^a   Li, Qian ^a   Xia, Bing ^a   Yu, Yong ^a   Wang, Yafei ^a   Zhao, Zhigang ^a   Zhang, Yizhuo ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Clinical parameters; Diffuse large B cell lymphoma (DLBCL); Immunohistochemistry; Toll like receptor 4 (TLR4); Tumor associated macrophages (TAMs)

Indexed keywords

BETA 2 MICROGLOBULIN; CD68 ANTIGEN; LACTATE DEHYDROGENASE; TOLL LIKE RECEPTOR 4; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; TLR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; ASSOCIATION; CANCER REGRESSION; CANCER STAGING; CELL INFILTRATION; CLINICAL FEATURE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERNATIONAL PROGNOSTIC INDEX; LARGE CELL LYMPHOMA; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETROSPECTIVE STUDY; SPLENOMEGALY; TREATMENT RESPONSE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; TUMOR VOLUME; BIOSYNTHESIS; GERMINAL CENTER; IMMUNOLOGY; MACROPHAGE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROCEDURES; PROGNOSIS; TREATMENT OUTCOME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BETA 2-MICROGLOBULIN; FEMALE; GERMINAL CENTER; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, LARGE B-CELL, DIFFUSE; MACROPHAGES; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; TOLL-LIKE RECEPTOR 4; TREATMENT OUTCOME;

EID: 84937513483     PISSN: 10929134     EISSN: 15328198     Source Type: Journal    
DOI: 10.1016/j.anndiagpath.2015.04.008     Document Type: Article

References (53)

1. R. Chung, R. Lai, P. Wei, J. Lee, J. Hanson, A.R. Belch, and et al. Concordant but not discordant bone marrow involvement in diffuse large B-cell lymphoma predicts a poor clinical outcome independent of the International Prognostic Index Blood 110 2007 1278 1282
2. M.R. Staudt, Y. Kanan, J.H. Jeong, J.F. Papin, R. Hines-Boykin, and D.P. Dittmer The tumor microenvironment controls primary effusion lymphoma growth in vivo Cancer Res 64 2004 4790 4799
3. A. Sanchez-Aguilera, C. Montalban, P. de la Cueva, L. Sanchez-Verde, M.M. Morente, M. Garcia-Cosio, and et al. Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma Blood 108 2006 662 668
4. D. de Jong, A. Koster, A. Hagenbeek, J. Raemaekers, D. Veldhuizen, S. Heisterkamp, and et al. Impact of the tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols Haematologica 94 2009 70 77
5. L. Bingle, N.J. Brown, and C.E. Lewis The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies J Pathol 196 2002 254 265
6. Y. Nakayama, N. Nagashima, N. Minagawa, Y. Inoue, T. Katsuki, K. Onitsuka, and et al. Relationships between tumor-associated macrophages and clinicopathological factors in patients with colorectal cancer Anticancer Res 22 2002 4291 4296
7. M.A. Zaki, N. Wada, J. Ikeda, H. Shibayama, K. Hashimoto, T. Yamagami, and et al. Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma Virchows Arch 459 2011 361 366
8. M.H. Barros, R. Hassan, and G. Niedobitek Tumor-associated macrophages in pediatric classical Hodgkin lymphoma: association with Epstein-Barr virus, lymphocyte subsets, and prognostic impact Clin Cancer Res 18 2012 3762 3771
9. L. Panico, F. Ronconi, M. Lepore, V. Tenneriello, N. Cantore, A.C. Dell'angelo, and et al. Prognostic role of tumor-associated macrophages and angiogenesis in classical Hodgkin lymphoma Leuk Lymphoma 54 2013 2418 2425
10. M. Taskinen, M.L. Karjalainen-Lindsberg, H. Nyman, L.M. Eerola, and S. Leppa A high tumor-associated macrophage content predicts favorable outcome in follicular lymphoma patients treated with rituximab and cyclophosphamide-doxorubicin-vincristine-prednisone Clin Cancer Res 13 2007 5784 5789
11. R. Medzhitov, P. Preston-Hurlburt, and C.A. Janeway Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 1997 394 397
12. B. Huang, J. Zhao, H. Li, K.L. He, Y. Chen, S.H. Chen, and et al. Toll-like receptors on tumor cells facilitate evasion of immune surveillance Cancer Res 65 2005 5009 5014
13. G. Elson, I. Dunn-Siegrist, B. Daubeuf, and J. Pugin Contribution of Toll-like receptors to the innate immune response to gram-negative and gram-positive bacteria Blood 109 2007 1574 1583
14. W. He, Q. Liu, L. Wang, W. Chen, N. Li, and X. Cao TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance Mol Immunol 44 2007 2850 2859
15. N. Simiantonaki, U. Kurzik-Dumke, G. Karyofylli, C. Jayasinghe, R. Michel-Schmidt, and C.J. Kirkpatrick Reduced expression of TLR4 is associated with the metastatic status of human colorectal cancer Int J Mol Med 20 2007 21 29
16. M.R. Chicoine, M. Zahner, E.K. Won, R.R. Kalra, T. Kitamura, A. Perry, and et al. The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4 Neurosurgery 60 2007 372 380 [discussion 381]
17. G. Delsol The 2008 WHO lymphoma classification Ann Pathol 28 2008 S20 S24 [Spec No 1]
18. C. Steidl, T. Lee, S.P. Shah, P. Farinha, G. Han, T. Nayar, and et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma N Engl J Med 362 2010 875 885
19. B. Li, M. Shi, J. Li, H. Zhang, B. Chen, L. Chen, and et al. Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma Stem Cells Dev 16 2007 921 930
20. C. Visco, Y. Li, Z.Y. Xu-Monette, R.N. Miranda, T.M. Green, A. Tzankov, and et al. Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study Leukemia 26 2012 2103 2113
21. X. Wei, F. Huang, Y. Wei, H. Jing, M. Xie, X. Hao, and et al. Low lymphocyte-to-monocyte ratio predicts unfavorable prognosis in non-germinal center type diffuse large B-cell lymphoma Leuk Res 38 2014 694 698
22. S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
23. B. Ruffell, N.I. Affara, and L.M. Coussens Differential macrophage programming in the tumor microenvironment Trends Immunol 33 2012 119 126
24. K. Fukuda, A. Kobayashi, and K. Watabe The role of tumor-associated macrophage in tumor progression Front Biosci (Schol Ed) 4 2012 787 798
25. S.K. Biswas, and A. Mantovani Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm Nat Immunol 11 2010 889 896
26. B.Z. Qian, and J.W. Pollard Macrophage diversity enhances tumor progression and metastasis Cell 141 2010 39 51
27. T. Hagemann, T. Lawrence, I. McNeish, K.A. Charles, H. Kulbe, R.G. Thompson, and et al. "Re-educating" tumor-associated macrophages by targeting NF-kappaB J Exp Med 205 2008 1261 1268
28. Y. Luo, H. Zhou, J. Krueger, C. Kaplan, S.H. Lee, C. Dolman, and et al. Targeting tumor-associated macrophages as a novel strategy against breast cancer J Clin Invest 116 2006 2132 2141
29. I. Takanami, K. Takeuchi, and S. Kodaira Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: association with angiogenesis and poor prognosis Oncology 57 1999 138 142
30. I.F. Lissbrant, P. Stattin, P. Wikstrom, J.E. Damber, L. Egevad, and A. Bergh Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival Int J Oncol 17 2000 445 451
31. S. Shimura, G. Yang, S. Ebara, T.M. Wheeler, A. Frolov, and T.C. Thompson Reduced infiltration of tumor-associated macrophages in human prostate cancer: association with cancer progression Cancer Res 60 2000 5857 5861
32. Y. Komohara, D. Niino, Y. Saito, K. Ohnishi, H. Horlad, and K. Ohshima Clinical significance of CD163 tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma Cancer Sci 104 2013 945 951
33. C. Casulo, M. Arcila, O.L. Bohn, J. Teruya-Feldstein, J. Maragulia, and C.H. Moskowitz Tumor associated macrophages in relapsed and refractory Hodgkin lymphoma Leuk Res 37 2013 1178 1183
34. S. Hasselblom, U. Hansson, M. Sigurdardottir, H. Nilsson-Ehle, B. Ridell, and P.O. Andersson Expression of CD68+ tumor-associated macrophages in patients with diffuse large B-cell lymphoma and its relation to prognosis Pathol Int 58 2008 529 532
35. N. Wada, M.A.A. Zaki, Y. Hori, K. Hashimoto, M. Tsukaguchi, Y. Tatsumi, and et al. Tumour-associated macrophages in diffuse large B-cell lymphoma: a study of the Osaka Lymphoma Study Group Histopathology 60 2012 313 319
36. S.J. Nam, H. Go, J.H. Paik, T.M. Kim, D.S. Heo, C.W. Kim, and et al. An increase of M2 macrophages predicts poor prognosis in patients with diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone Leuk Lymphoma 55 2014 2466 2476
37. F. Marchesi, M. Cirillo, A. Bianchi, M. Gately, O.M. Olimpieri, E. Cerchiara, and et al. High density of CD68+/CD163+ tumour-associated macrophages (M2-TAM) at diagnosis is significantly correlated to unfavorable prognostic factors and to poor clinical outcomes in patients with diffuse large B-cell lymphoma Hematol Oncol 2014 10.1002/hon.2142
38. S. Riihijarvi, I. Fiskvik, M. Taskinen, H. Vajavaara, M. Tikkala, O. Yri, and et al. Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial Haematologica 100 2015 238 245
39. A. Duletic-Nacinovic, S. Stifter, B. Marijic, K. Lucin, T. Valkovic, D. Petranovic, and et al. Serum IL-6, IL-8, IL-10 and beta2-microglobulin in association with International Prognostic Index in diffuse large B cell lymphoma Tumori 94 2008 511 517
40. A. Iwasaki, and R. Medzhitov Toll-like receptor control of the adaptive immune responses Nat Immunol 5 2004 987 995
41. K.Q. Chen, J. Huang, W.H. Gong, P. Iribarren, N.M. Dunlop, and J.M. Wang Toll-like receptors in inflammation, infection and cancer Int Immunopharmacol 7 2007 1271 1285
42. T.M. Earl, I.B. Nicoud, J.M. Pierce, J.P. Wright, N.E. Majoras, J.E. Rubin, and et al. Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis Ann Surg Oncol 16 2009 1043 1050
43. S. Pandey, R.D. Mittal, M. Srivastava, K. Srivastava, S. Singh, S. Srivastava, and et al. Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women Gynecol Oncol 114 2009 501 505
44. Y.B. Zhang, F.L. He, M. Fang, T.F. Hua, B.D. Hu, Z.H. Zhang, and et al. Increased expression of Toll-like receptors 4 and 9 in human lung cancer Mol Biol Rep 36 2009 1475 1481
45. H.Y. Fu, C. Li, W. Yang, X.D. Gai, T. Jia, Y.M. Lei, and et al. FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape Acta Histochem 115 2013 151 157
46. E.L. Wang, Z.R. Qian, M. Nakasono, T. Tanahashi, K. Yoshimoto, Y. Bando, and et al. High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer Br J Cancer 102 2010 908 915
47. A. Ahmed, J.H. Wang, and H.P. Redmond Silencing of TLR4 increases tumor progression and lung metastasis in a murine model of breast cancer Ann Surg Oncol 20 Suppl 3 2013 S389 S396
48. Y.W. Koh, H.J. Kang, C. Park, D.H. Yoon, S. Kim, C. Suh, and et al. The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages Oncologist 17 2012 871 880
49. J.A. Harris, S. Jain, Q. Ren, A. Zarineh, C. Liu, and S. Ibrahim CD163 versus CD68 in tumor associated macrophages of classical Hodgkin lymphoma Diagn Pathol 7 2012 12
50. Z. Huang, Y. Yang, Y. Jiang, J. Shao, X. Sun, J. Chen, and et al. Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers Biomaterials 34 2013 746 755
51. C.Y. Liu, J.Y. Xu, X.Y. Shi, W. Huang, T.Y. Ruan, P. Xie, and et al. M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway Lab Invest 93 2013 844 854
52. F. Hakim, Y. Wang, S.X. Zhang, J. Zheng, E.S. Yolcu, A. Carreras, and et al. Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling Cancer Res 74 2014 1329 1337
53. L.C. Li, Z. Varghese, J.F. Moorhead, C.T. Lee, J.B. Chen, and X.Z. Ruan Cross-talk between TLR4-MyD88-NF-kappaB and SCAP-SREBP2 pathways mediates macrophage foam cell formation Am J Physiol Heart Circ Physiol 304 2013 H874 H884