Discovery of substituted 1,4-dihydroquinolines as novel class of ABCB1 modulators

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 5015-5021

  Hemmer, Marc ^a   Krawczyk, Sören ^a   Simon, Ina ^a   Lage, Hermann ^b   Hilgeroth, Andreas ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Drug discovery; Efflux pump inhibition; Inhibitor; Multidrug resistance (MDR); Structure activity data

Indexed keywords

ANTINEOPLASTIC AGENT; DAUNORUBICIN; ETHYL 1 (3 METHOXYBENZYL) 4 (3 METHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (3 METHOXYBENZYL) 4 (3,4 DIMETHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (3 METHOXYBENZYL) 4 (3,5 DIMETHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (3 METHOXYBENZYL) 4 (4 METHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (3 METHOXYBENZYL)QUINOLINIUM 3 CARBOXYLATE BROMIDE; ETHYL 1 (4 METHOXYBENZYL) 4 (3 METHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (4 METHOXYBENZYL) 4 (3,4 DIMETHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (4 METHOXYBENZYL) 4 (3,5 DIMETHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (4 METHOXYBENZYL) 4 (4 METHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 (4 METHOXYBENZYL)QUINOLINIUM 3 CARBOXYLATE BROMIDE; ETHYL 1 BENZYL 4 (3,4 DIMETHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 BENZYL 4 (3,5 DIMETHOXYPHENYL) 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 BENZYL 4 PHENYL 1,4 DIHYDROQUINOLINIUM 3 CARBOXYLATE; ETHYL 1 BENZYLQUINOLINIUM 3 CARBOXYLATE BROMIDE; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG; 1,4-DIHYDROQUINOLINE; ABCB1 PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN; QUINOLINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC50; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN EXPRESSION; STOMACH CARCINOMA; STRUCTURE ACTIVITY RELATION; T CELL LYMPHOMA; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; ENZYME SPECIFICITY; HUMAN; METABOLISM; PRECLINICAL STUDY; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; HUMANS; P-GLYCOPROTEINS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84937512610     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.05.016     Document Type: Article

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