Cold-inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels

Circulation Research

Volumn 116, Issue 10, 2015, Pages 1655-1659

  Li, Jun ^a,b   Xie, Duanyang ^a   Huang, Jian ^a   Lv, Fei ^a   Shi, Dan ^a,b   Liu, Yi ^a,b   Lin, Li ^a,b   Geng, Li ^a   Wu, Yufei ^a   Liang, Dandan ^a,b   Chen, Yi Han ^a,b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

Action potential; Cardiac; Cold shock proteins; Ion channels; Myocytes; Repolarization

Indexed keywords

COLD INDUCIBLE RNA BINDING PROTEIN; MESSENGER RNA; POTASSIUM CHANNEL; RNA BINDING PROTEIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; CIRP PROTEIN, RAT; COLD SHOCK PROTEIN; KCND2 PROTEIN, RAT; KCND3 PROTEIN, RAT; KCNIP2 PROTEIN, RAT; KV CHANNEL INTERACTING PROTEIN; PROTEIN BINDING; SHAL POTASSIUM CHANNEL;

ACTION POTENTIAL DURATION; ALPHA CHAIN; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENOME; HEART FUNCTION; HEART MUSCLE CELL; HEART REPOLARIZATION; KNOCKOUT RAT; NONHUMAN; POTASSIUM CURRENT; PR INTERVAL; PRIORITY JOURNAL; QRS INTERVAL; QTC INTERVAL; RAT; RR INTERVAL; WILD TYPE; ACTION POTENTIAL; ANIMAL; BINDING SITE; CELL CULTURE; CHANNEL GATING; DEFICIENCY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HEART RATE; METABOLISM; PHENOTYPE; TIME; TRANSGENIC RAT;

ACTION POTENTIALS; ANIMALS; BINDING SITES; CELLS, CULTURED; COLD SHOCK PROTEINS AND PEPTIDES; GENOTYPE; HEART RATE; ION CHANNEL GATING; KV CHANNEL-INTERACTING PROTEINS; MYOCYTES, CARDIAC; PHENOTYPE; PROTEIN BINDING; RATS, TRANSGENIC; RNA, MESSENGER; RNA-BINDING PROTEINS; SHAL POTASSIUM CHANNELS; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84937512418     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.306287     Document Type: Article

References (15)

1. Lunde BM, Moore C, Varani G., RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol 2007; 8: 479-490. doi: 10.1038/nrm2178
2. Nishiyama H, Danno S, Kaneko Y, Itoh K, Yokoi H, Fukumoto M, Okuno H, Millán JL, Matsuda T, Yoshida O, Fujita J., Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. Am J Pathol 1998 152 289 296
3. 2 on the cold stress protein CIRP expression in rat neuronal cells. Free Radic Biol Med 1999 27 1238 1244
4. Qiang X, Yang WL, Wu R, Zhou M, Jacob A, Dong W, Kuncewitch M, Ji Y, Yang H, Wang H, Fujita J, Nicastro J, Coppa GF, Tracey KJ, Wang P., Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat Med 2013; 19: 1489-1495. doi: 10.1038/nm.3368
5. Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J., A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. J Cell Biol 1997 137 899 908
6. Sakurai T, Itoh K, Higashitsuji H, Nonoguchi K, Liu Y, Watanabe H, Nakano T, Fukumoto M, Chiba T, Fujita J., Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim Biophys Acta 2006; 1763: 290-295. doi: 10.1016/j.bbamcr.2006.02.007
7. Saito K, Fukuda N, Matsumoto T, Iribe Y, Tsunemi A, Kazama T, Yoshida-Noro C, Hayashi N., Moderate low temperature preserves the stemness of neural stem cells and suppresses apoptosis of the cells via activation of the cold-inducible RNA binding protein. Brain Res 2010; 1358: 20-29. doi: 10.1016/j.brainres.2010.08.048
8. 2-induced apoptosis in rat cortical neurons. Brain Res 2012; 1441: 47-52. doi: 10.1016/j.brainres.2011.12.053
9. Sheikh MS, Carrier F, Papathanasiou MA, Hollander MC, Zhan Q, Yu K, Fornace AJ Jr, Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein. J Biol Chem 1997 272 26720 26726
10. Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, Fujita J, Seeger K., Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. J Cell Sci 2004; 117: 1785-1794. doi: 10.1242/jcs.01026
11. Morf J, Rey G, Schneider K, Stratmann M, Fujita J, Naef F, Schibler U., Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally. Science 2012; 338: 379-383. doi: 10.1126/science.1217726
12. Nerbonne JM, Kass RS., Molecular physiology of cardiac repolarization. Physiol Rev 2005; 85: 1205-1253. doi: 10.1152/physrev.00002.2005
13. Nakamura TY, Coetzee WA, Vega-Saenz De Miera E, Artman M, Rudy B., Modulation of Kv4 channels, key components of rat ventricular transient outward K+ current, by PKC. Am J Physiol 1997 273 H1775 H1786
14. Birnbaum SG, Varga AW, Yuan LL, Anderson AE, Sweatt JD, Schrader LA., Structure and function of Kv4-family transient potassium channels. Physiol Rev 2004; 84: 803-833. doi: 10.1152/physrev.00039.2003
15. Antzelevitch C., Cardiac repolarization. The long and short of it. Europace 2005; 7 (Suppl 2) 3-9. doi: 10.1016/j.eupc.2005.05.010