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Volumn 33, Issue 4, 2015, Pages 492-497

Pathophysiology of Liver Fibrosis

Author keywords

Cirrhosis; Fibrosis; Hepatic stellate cells; Liver; Myofibroblasts

Indexed keywords

APOPTOSIS; ARTICLE; CHRONIC LIVER DISEASE; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; FIBROGENESIS; HUMAN; INNATE IMMUNITY; INTESTINE FLORA; LIVER CIRRHOSIS; LIVER FIBROSIS; MICROENVIRONMENT; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PORTAL HYPERTENSION; PRIORITY JOURNAL; STELLATE CELL; TISSUE INJURY; WOUND HEALING; ANIMAL; COMPLICATION; DISEASE COURSE; EXTRACELLULAR MATRIX; LIVER; LIVER DISEASE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; RAT;

EID: 84937399899     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000374096     Document Type: Article
Times cited : (128)

References (51)
  • 2
    • 79955701910 scopus 로고    scopus 로고
    • Scraping fibrosis: Expressway to the core of fibrosis
    • Mehal WZ, Iredale J, Friedman SL: Scraping fibrosis: expressway to the core of fibrosis. Nat Med 2011; 17: 552-553.
    • (2011) Nat Med , vol.17 , pp. 552-553
    • Mehal, W.Z.1    Iredale, J.2    Friedman, S.L.3
  • 3
    • 3543098600 scopus 로고    scopus 로고
    • Liver fibrosis: From the bench to clinical targets
    • Pinzani M, Rombouts K: Liver fibrosis: from the bench to clinical targets. Dig Liver Dis 2004; 36: 231-242.
    • (2004) Dig Liver Dis , vol.36 , pp. 231-242
    • Pinzani, M.1    Rombouts, K.2
  • 4
    • 14944343292 scopus 로고    scopus 로고
    • Fibrosis in chronic liver diseases: Diagnosis and management
    • Pinzani M, Rombouts K, Colagrande S: Fibrosis in chronic liver diseases: diagnosis and management. J Hepatol 2005; 42(suppl 1):S22-S36.
    • (2005) J Hepatol , vol.42 , pp. S22-S36
    • Pinzani, M.1    Rombouts, K.2    Colagrande, S.3
  • 8
    • 84881558364 scopus 로고    scopus 로고
    • Beyond scoring: A modern interpretation of disease progression in chronic liver disease
    • Rosselli M, Macnaughtan J, Jalan R, Pinzani M: Beyond scoring: a modern interpretation of disease progression in chronic liver disease. Gut 2013; 63: 1234-1241.
    • (2013) Gut , vol.63 , pp. 1234-1241
    • Rosselli, M.1    Macnaughtan, J.2    Jalan, R.3    Pinzani, M.4
  • 9
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman SL: Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134: 1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 10
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • Wynn TA: Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007; 117: 524-529.
    • (2007) J Clin Invest , vol.117 , pp. 524-529
    • Wynn, T.A.1
  • 13
    • 0019230284 scopus 로고
    • Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs
    • Wake K: Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol 1980; 66: 303-353.
    • (1980) Rev Cytol , vol.66 , pp. 303-353
    • Wake, K.1
  • 14
    • 0028535872 scopus 로고
    • Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
    • Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A: Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994; 1: 71-81.
    • (1994) Mol Med , vol.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3    Hogan, M.4    Cerami, A.5
  • 15
    • 33646914221 scopus 로고    scopus 로고
    • The role of circulating fibrocytes in fibrosis
    • Quan TE, Cowper SE, Bucala R: The role of circulating fibrocytes in fibrosis. Curr Rheumatol Rep 2006; 8: 145-150.
    • (2006) Curr Rheumatol Rep , vol.8 , pp. 145-150
    • Quan, T.E.1    Cowper, S.E.2    Bucala, R.3
  • 16
    • 69949160564 scopus 로고    scopus 로고
    • Redox mechanisms in hepatic chronic wound healing and fibrogenesis
    • Novo E, Parola M: Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair 2008; 1: 5.
    • (2008) Fibrogenesis Tissue Repair , vol.1 , pp. 5
    • Novo, E.1    Parola, M.2
  • 17
    • 40849083460 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver: The mist gradually clear
    • De Alwis NMW, Day CP: Non-alcoholic fatty liver: the mist gradually clear. J Hepatol 2008; 48:S105-S112.
    • (2008) J Hepatol , vol.48 , pp. S105-S112
    • De Alwis, N.M.W.1    Day, C.P.2
  • 18
  • 19
    • 84862017188 scopus 로고    scopus 로고
    • Gut microbiota and nonalcoholic fatty liver disease
    • Machado MV, Cortez-Pinto H: Gut microbiota and nonalcoholic fatty liver disease. Ann Hepatol 2012; 11: 440-449.
    • (2012) Ann Hepatol , vol.11 , pp. 440-449
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 21
    • 34447317835 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietin-1 as hypoxia-dependent autocrine and paracrine factors stimulating migration and chemotaxis of activated human hepatic stellate cells
    • Novo E, Cannito S, Zamara E, et al: Vascular endothelial growth factor and angiopoietin-1 as hypoxia-dependent autocrine and paracrine factors stimulating migration and chemotaxis of activated human hepatic stellate cells. Am J Pathol 2007; 170: 1942-1953.
    • (2007) Am J Pathol , vol.170 , pp. 1942-1953
    • Novo, E.1    Cannito, S.2    Zamara, E.3
  • 23
    • 84904795250 scopus 로고    scopus 로고
    • Epigenetics in liver disease
    • Mann DA: Epigenetics in liver disease. Hepatology 2014; 60: 1418-1425.
    • (2014) Hepatology , vol.60 , pp. 1418-1425
    • Mann, D.A.1
  • 24
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl B, Brenner DA: Interactions between the intestinal microbiome and liver diseases. Gastroenterology 2014; 146: 1513-1524.
    • (2014) Gastroenterology , vol.146 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 25
    • 84862017188 scopus 로고    scopus 로고
    • Gut microbiota and nonalcoholic fatty liver disease
    • Machado MV, Cortez-Pinto H: Gut microbiota and nonalcoholic fatty liver disease. Ann Hepatol 2012; 11: 440-449.
    • (2012) Ann Hepatol , vol.11 , pp. 440-449
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 26
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 27
    • 0038281478 scopus 로고    scopus 로고
    • Intestinal myofibroblasts in innate immune responses of the intestine
    • Otte JM, Rosenberg IM, Podolsky DK: Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 2003; 124: 1866-1878.
    • (2003) Gastroenterology , vol.124 , pp. 1866-1878
    • Otte, J.M.1    Rosenberg, I.M.2    Podolsky, D.K.3
  • 28
    • 27144512697 scopus 로고    scopus 로고
    • Chemokines provide the sustained inflammatory bridge between innate and acquired immunity
    • Coelho AL, Hogaboam CM, Kunkel SL: Chemokines provide the sustained inflammatory bridge between innate and acquired immunity. Cytokine Growth Factor Rev 2005; 16: 553-560.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 553-560
    • Coelho, A.L.1    Hogaboam, C.M.2    Kunkel, S.L.3
  • 30
    • 33847040759 scopus 로고    scopus 로고
    • Increased intestinal permeability in obese mice: New evidences in the pathogenesis of nonalcoholic steatohepatitis
    • Brun P, Castagliuolo I, Di Leo V, et al: Increased intestinal permeability in obese mice: new evidences in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 292:G518-G525.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G518-G525
    • Brun, P.1    Castagliuolo, I.2    Di Leo, V.3
  • 31
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • Seki E, Brenner DA: Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008; 48: 322-335.
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 32
    • 17144455384 scopus 로고    scopus 로고
    • Histological improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy
    • Shiratori Y, Imazeki F, Moriyama M, Yano M, Arakawa Y, Yokosuka O, et al: Histological improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med 2000; 132: 517-524.
    • (2000) Ann Intern Med , vol.132 , pp. 517-524
    • Shiratori, Y.1    Imazeki, F.2    Moriyama, M.3    Yano, M.4    Arakawa, Y.5    Yokosuka, O.6
  • 33
    • 0035742752 scopus 로고    scopus 로고
    • Decreasing fibrogenesis: An immunoistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B
    • Kweon YO, Goodman ZD, Dienstag JL, Shiff ER, Brown NA, Burkardt E, et al: Decreasing fibrogenesis: an immunoistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol 2001; 35: 749-755.
    • (2001) J Hepatol , vol.35 , pp. 749-755
    • Kweon, Y.O.1    Goodman, Z.D.2    Dienstag, J.L.3    Shiff, E.R.4    Brown, N.A.5    Burkardt, E.6
  • 35
    • 0036242165 scopus 로고    scopus 로고
    • Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C
    • Poynard T, McHutchison J, Manns M, Trepo C, Lindsay K, Goodman Z, et al: Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 2002; 122: 1303-1313.
    • (2002) Gastroenterology , vol.122 , pp. 1303-1313
    • Poynard, T.1    McHutchison, J.2    Manns, M.3    Trepo, C.4    Lindsay, K.5    Goodman, Z.6
  • 36
    • 2942568157 scopus 로고    scopus 로고
    • Long-term benefit of interferon alpha therapy of chronic hepatitis D: Regression of advanced hepatic fibrosis
    • Farci P, Roskams T, Chessa L, Peddis G, Mazzoleni AP, Scioscia R, et al: Long-term benefit of interferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis. Gastroenterology 2004; 126: 1740-1749.
    • (2004) Gastroenterology , vol.126 , pp. 1740-1749
    • Farci, P.1    Roskams, T.2    Chessa, L.3    Peddis, G.4    Mazzoleni, A.P.5    Scioscia, R.6
  • 38
    • 34548806374 scopus 로고    scopus 로고
    • Sustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients
    • Hong Kong Liver Fibrosis Study
    • Hui CK, Leung N, Shek TW, Yao H, Lee WK, Lai JY, Lai ST, Wong WM, Lai LS, Poon RT, Lo CM, Fan ST, Lau GK, Hong Kong Liver Fibrosis Study: Sustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients. Hepatology 2007; 46: 690-698.
    • (2007) Hepatology , vol.46 , pp. 690-698
    • Hui, C.K.1    Leung, N.2    Shek, T.W.3    Yao, H.4    Lee, W.K.5    Lai, J.Y.6    Lai, S.T.7    Wong, W.M.8    Lai, L.S.9    Poon, R.T.10    Lo, C.M.11    Fan, S.T.12    Lau, G.K.13
  • 39
    • 0030692704 scopus 로고    scopus 로고
    • Reversibility of hepatic fibrosis in autoimmune hepatitis
    • Dufour JF, DeLellis R, Kaplan MM: Reversibility of hepatic fibrosis in autoimmune hepatitis. Ann Intern Med 1997; 127: 981-985.
    • (1997) Ann Intern Med , vol.127 , pp. 981-985
    • Dufour, J.F.1    Delellis, R.2    Kaplan, M.M.3
  • 40
    • 14844337493 scopus 로고    scopus 로고
    • Long-term management of alcoholic liver disease
    • Wakim-Fleming J, Mullen KD: Long-term management of alcoholic liver disease. Clin Liver Dis 2005; 9: 135-149.
    • (2005) Clin Liver Dis , vol.9 , pp. 135-149
    • Wakim-Fleming, J.1    Mullen, K.D.2
  • 41
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • Dixon JB, Bhathal PS, Hughes NR, O'Brien PE: Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology 2004; 39: 1647-1654.
    • (2004) Hepatology , vol.39 , pp. 1647-1654
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3    O'brien, P.E.4
  • 42
    • 0348047323 scopus 로고    scopus 로고
    • Effects of surgical treatment of the metabolic syndrome on liver fibrosis, and cirrhosis
    • Kral JG, Thung SN, Biron S, Hould FS, Lebel S, Marceau S, et al: Effects of surgical treatment of the metabolic syndrome on liver fibrosis, and cirrhosis. Surgery 2004; 135: 48-58.
    • (2004) Surgery , vol.135 , pp. 48-58
    • Kral, J.G.1    Thung, S.N.2    Biron, S.3    Hould, F.S.4    Lebel, S.5    Marceau, S.6
  • 43
    • 1942470986 scopus 로고    scopus 로고
    • Cirrhosis reversal: A duel between dogma and myth
    • Desmet VJ, Roskams T: Cirrhosis reversal: a duel between dogma and myth. J Hepatol 2004; 40: 860-867.
    • (2004) J Hepatol , vol.40 , pp. 860-867
    • Desmet, V.J.1    Roskams, T.2
  • 44
    • 0033749190 scopus 로고    scopus 로고
    • Regression of human cirrhosis: Morphologic features and the genesis of incomplete septal cirrhosis
    • Wanless IR, Nakashima E, Sherman M: Regression of human cirrhosis: morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med 2000; 124: 1599-1607.
    • (2000) Arch Pathol Lab Med , vol.124 , pp. 1599-1607
    • Wanless, I.R.1    Nakashima, E.2    Sherman, M.3
  • 45
    • 0037383894 scopus 로고    scopus 로고
    • Milestones in liver disease: Scoring chronic hepatitis
    • Desmet VJ: Milestones in liver disease: scoring chronic hepatitis. J Hepatol 2003; 38: 382-386.
    • (2003) J Hepatol , vol.38 , pp. 382-386
    • Desmet, V.J.1
  • 46
    • 0021055147 scopus 로고
    • The Copenhagen study group for liver disease: Conversion of micronodular into macronodular cirrhosis
    • Fauerholdt L, Schlichting P, Christensen E, Poulsen H, Tygstrup N, Juhl E: The Copenhagen study group for liver disease: conversion of micronodular into macronodular cirrhosis. Hepatology 1983; 3: 928-931.
    • (1983) Hepatology , vol.3 , pp. 928-931
    • Fauerholdt, L.1    Schlichting, P.2    Christensen, E.3    Poulsen, H.4    Tygstrup, N.5    Juhl, E.6
  • 47
    • 0030175327 scopus 로고    scopus 로고
    • Pyridinoline collagen cross-links in patients with chronic viral hepatitis and cirrhosis
    • Hayasaka A, Ilda S, Suzuki N, Kondo F, Miyazaki M, Yonemitsu H: Pyridinoline collagen cross-links in patients with chronic viral hepatitis and cirrhosis. J Hepatol 1996; 24: 692-698.
    • (1996) J Hepatol , vol.24 , pp. 692-698
    • Hayasaka, A.1    Ilda, S.2    Suzuki, N.3    Kondo, F.4    Miyazaki, M.5    Yonemitsu, H.6
  • 50
    • 70350077449 scopus 로고    scopus 로고
    • Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies
    • Popov Y, Schuppan D: Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology 2009; 50: 1294-1306.
    • (2009) Hepatology , vol.50 , pp. 1294-1306
    • Popov, Y.1    Schuppan, D.2
  • 51
    • 84856461322 scopus 로고    scopus 로고
    • Antifibrotic therapy: Lost in translation
    • Shuppan D, Pinzani M: Antifibrotic therapy: lost in translation? J Hepatol 2012; 56(suppl):S66-S74.
    • (2012) J Hepatol , vol.56 , pp. S66-S74
    • Shuppan, D.1    Pinzani, M.2


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