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Volumn 29, Issue 2, 2015, Pages 374-384

Caveolin modulates integrin function and mechanical activation in the cardiomyocyte

Author keywords

Caveolae; Focal adhesions; Mechanotransduction; Myocardium

Indexed keywords

BETA1 INTEGRIN; CAVEOLIN 3; INTEGRIN BETA1D; PROTEIN HYDROLYSATE; UNCLASSIFIED DRUG; CAV3 PROTEIN, MOUSE; INTEGRIN;

EID: 84937396207     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-243139     Document Type: Article
Times cited : (23)

References (58)
  • 1
    • 0035827723 scopus 로고    scopus 로고
    • Integrins and the myocardium
    • Ross, R. S., and Borg, T. K. (2001) Integrins and the myocardium. Circ. Res. 88, 1112-1119
    • (2001) Circ. Res. , vol.88 , pp. 1112-1119
    • Ross, R.S.1    Borg, T.K.2
  • 2
    • 3042723613 scopus 로고    scopus 로고
    • Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading
    • Zimerman, B., Volberg, T., and Geiger, B. (2004) Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading. Cell Motil. Cytoskeleton 58, 143-159
    • (2004) Cell Motil. Cytoskeleton , vol.58 , pp. 143-159
    • Zimerman, B.1    Volberg, T.2    Geiger, B.3
  • 3
    • 0037188939 scopus 로고    scopus 로고
    • Importance of integrin signaling in myocyte growth and survival
    • Kuppuswamy, D. (2002) Importance of integrin signaling in myocyte growth and survival. Circ. Res. 90, 1240-1242
    • (2002) Circ. Res. , vol.90 , pp. 1240-1242
    • Kuppuswamy, D.1
  • 4
    • 0026245524 scopus 로고
    • Integrins as mechanochemical transducers
    • Ingber, D. (1991) Integrins as mechanochemical transducers. Curr. Opin. Cell Biol. 3, 841-848
    • (1991) Curr. Opin. Cell Biol. , vol.3 , pp. 841-848
    • Ingber, D.1
  • 5
    • 84894133788 scopus 로고    scopus 로고
    • Integrins and integrin-associated proteins in the cardiac myocyte
    • Israeli-Rosenberg, S., Manso, A. M., Okada, H., and Ross, R. S. (2014) Integrins and integrin-associated proteins in the cardiac myocyte. Circ. Res. 114, 572-586
    • (2014) Circ. Res. , vol.114 , pp. 572-586
    • Israeli-Rosenberg, S.1    Manso, A.M.2    Okada, H.3    Ross, R.S.4
  • 8
    • 84866298370 scopus 로고    scopus 로고
    • Caveolae, caveolins, cavins, and endothelial cell function: New insights
    • Sowa, G. (2012) Caveolae, caveolins, cavins, and endothelial cell function: new insights. Front. Physiol. 2, 120 doi:10.3389/fphys.2011.00120
    • (2012) Front. Physiol. , vol.2 , pp. 120
    • Sowa, G.1
  • 9
    • 27844442717 scopus 로고    scopus 로고
    • Compartmentation of G-proteincoupled receptors and their signalling components in lipid rafts and caveolae
    • Insel, P. A., Head, B. P., Patel, H. H., Roth, D. M., Bundey, R. A., and Swaney, J. S. (2005) Compartmentation of G-proteincoupled receptors and their signalling components in lipid rafts and caveolae. Biochem. Soc. Trans. 33, 1131-1134
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 1131-1134
    • Insel, P.A.1    Head, B.P.2    Patel, H.H.3    Roth, D.M.4    Bundey, R.A.5    Swaney, J.S.6
  • 10
    • 84907221124 scopus 로고    scopus 로고
    • Regulation of intracellular signaling and function by caveolin
    • E-pub ahead of print
    • Fridolfsson, H. N., Roth, D. M., Insel, P. A., and Patel, H. H. (2014) Regulation of intracellular signaling and function by caveolin. [E-pub ahead of print] FASEB J.
    • (2014) FASEB J.
    • Fridolfsson, H.N.1    Roth, D.M.2    Insel, P.A.3    Patel, H.H.4
  • 11
    • 84892178225 scopus 로고    scopus 로고
    • Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function: Membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling
    • Head, B. P., Patel, H. H., and Insel, P. A. (2014) Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim. Biophys. Acta 1838, 532-545
    • (2014) Biochim. Biophys. Acta , vol.1838 , pp. 532-545
    • Head, B.P.1    Patel, H.H.2    Insel, P.A.3
  • 12
    • 33749649546 scopus 로고    scopus 로고
    • Caveolae internalization regulates integrin-dependent signaling pathways
    • Echarri, A., and Del Pozo, M. A. (2006) Caveolae internalization regulates integrin-dependent signaling pathways. Cell Cycle 5, 2179-2182
    • (2006) Cell Cycle , vol.5 , pp. 2179-2182
    • Echarri, A.1    Del Pozo, M.A.2
  • 13
    • 79960320815 scopus 로고    scopus 로고
    • Caveolin 3-mediated integrin β1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix
    • Horiguchi, K., Fujiwara, K., Ilmiawati, C., Kikuchi, M., Tsukada, T., Kouki, T., and Yashiro, T. (2011) Caveolin 3-mediated integrin β1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix. J. Endocrinol. 210, 29-36
    • (2011) J. Endocrinol. , vol.210 , pp. 29-36
    • Horiguchi, K.1    Fujiwara, K.2    Ilmiawati, C.3    Kikuchi, M.4    Tsukada, T.5    Kouki, T.6    Yashiro, T.7
  • 14
    • 84888437192 scopus 로고    scopus 로고
    • Positioning of integrin β1, caveolin-1 and focal adhesion kinase on the adhered membrane of spreading cells
    • Jokhadar, S. Z., Majhenc, J., Svetina, S., and Batista, U. (2013) Positioning of integrin β1, caveolin-1 and focal adhesion kinase on the adhered membrane of spreading cells. Cell Biol. Int. 37, 1276-1284
    • (2013) Cell Biol. Int. , vol.37 , pp. 1276-1284
    • Jokhadar, S.Z.1    Majhenc, J.2    Svetina, S.3    Batista, U.4
  • 15
    • 79954986877 scopus 로고    scopus 로고
    • Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose
    • Lee, S. H., Lee, Y. J., Park, S. W., Kim, H. S., and Han, H. J. (2011) Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose. J. Cell. Physiol. 226, 1850-1859
    • (2011) J. Cell. Physiol. , vol.226 , pp. 1850-1859
    • Lee, S.H.1    Lee, Y.J.2    Park, S.W.3    Kim, H.S.4    Han, H.J.5
  • 19
    • 1342268582 scopus 로고    scopus 로고
    • Overexpression of P104L mutant caveolin-3 in mice develops hypertrophic cardiomyopathy with enhanced contractility in association with increased endothelial nitric oxide synthase activity
    • Ohsawa, Y., Toko, H., Katsura, M., Morimoto, K., Yamada, H., Ichikawa, Y., Murakami, T., Ohkuma, S., Komuro, I., and Sunada, Y. (2004) Overexpression of P104L mutant caveolin-3 in mice develops hypertrophic cardiomyopathy with enhanced contractility in association with increased endothelial nitric oxide synthase activity. Hum. Mol. Genet. 13, 151-157
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 151-157
    • Ohsawa, Y.1    Toko, H.2    Katsura, M.3    Morimoto, K.4    Yamada, H.5    Ichikawa, Y.6    Murakami, T.7    Ohkuma, S.8    Komuro, I.9    Sunada, Y.10
  • 26
    • 0036086808 scopus 로고    scopus 로고
    • Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII
    • Alden, K. J., Goldspink, P. H., Ruch, S. W., Buttrick, P. M., and García, J. (2002) Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII. Am. J. Physiol. Cell Physiol. 282, C768-C774
    • (2002) Am. J. Physiol. Cell Physiol. , vol.282 , pp. C768-C774
    • Alden, K.J.1    Goldspink, P.H.2    Ruch, S.W.3    Buttrick, P.M.4    García, J.5
  • 27
    • 0034533580 scopus 로고    scopus 로고
    • Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway
    • Pham, C. G., Harpf, A. E., Keller, R. S., Vu, H. T., Shai, S. Y., Loftus, J. C., and Ross, R. S. (2000) Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. Am. J. Physiol. Heart Circ. Physiol. 279, H2916-H2926
    • (2000) Am. J. Physiol. Heart Circ. Physiol. , vol.279 , pp. H2916-H2926
    • Pham, C.G.1    Harpf, A.E.2    Keller, R.S.3    Vu, H.T.4    Shai, S.Y.5    Loftus, J.C.6    Ross, R.S.7
  • 28
    • 24144462378 scopus 로고    scopus 로고
    • G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes
    • Head, B. P., Patel, H. H., Roth, D. M., Lai, N. C., Niesman, I. R., Farquhar, M. G., and Insel, P. A. (2005) G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J. Biol. Chem. 280, 31036-31044
    • (2005) J. Biol. Chem. , vol.280 , pp. 31036-31044
    • Head, B.P.1    Patel, H.H.2    Roth, D.M.3    Lai, N.C.4    Niesman, I.R.5    Farquhar, M.G.6    Insel, P.A.7
  • 34
  • 35
    • 0027421094 scopus 로고
    • A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1
    • Lenter, M., Uhlig, H., Hamann, A., Jenö, P., Imhof, B., and Vestweber, D. (1993) A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1. Proc. Natl. Acad. Sci. USA 90, 9051-9055
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9051-9055
    • Lenter, M.1    Uhlig, H.2    Hamann, A.3    Jenö, P.4    Imhof, B.5    Vestweber, D.6
  • 37
    • 0034627799 scopus 로고    scopus 로고
    • Expression of integrin subunit beta1B in integrin beta1-deficient GD25 cells does not interfere with alphaVbeta3 functions
    • Armulik, A., Svineng, G., Wennerberg, K., Fässler, R., and Johansson, S. (2000) Expression of integrin subunit beta1B in integrin beta1-deficient GD25 cells does not interfere with alphaVbeta3 functions. Exp. Cell Res. 254, 55-63
    • (2000) Exp. Cell Res. , vol.254 , pp. 55-63
    • Armulik, A.1    Svineng, G.2    Wennerberg, K.3    Fässler, R.4    Johansson, S.5
  • 39
    • 64049115544 scopus 로고    scopus 로고
    • Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: An integrating viewpoint
    • De Cavanagh, E. M., Ferder, M., Inserra, F., and Ferder, L. (2009) Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint. Am. J. Physiol. Heart Circ. Physiol. 296, H550-H558
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.296 , pp. H550-H558
    • De Cavanagh, E.M.1    Ferder, M.2    Inserra, F.3    Ferder, L.4
  • 41
    • 0012151543 scopus 로고    scopus 로고
    • Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle
    • Babbitt, C. J., Shai, S. Y., Harpf, A. E., Pham, C. G., and Ross, R. S. (2002) Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem. Cell Biol. 118, 431-439
    • (2002) Histochem. Cell Biol. , vol.118 , pp. 431-439
    • Babbitt, C.J.1    Shai, S.Y.2    Harpf, A.E.3    Pham, C.G.4    Ross, R.S.5
  • 42
    • 0034730790 scopus 로고    scopus 로고
    • Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart
    • Franchini, K. G., Torsoni, A. S., Soares, P. H., and Saad, M. J. (2000) Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart. Circ. Res. 87, 558-565
    • (2000) Circ. Res. , vol.87 , pp. 558-565
    • Franchini, K.G.1    Torsoni, A.S.2    Soares, P.H.3    Saad, M.J.4
  • 43
    • 0344507516 scopus 로고    scopus 로고
    • A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
    • Wei, Y., Yang, X., Liu, Q., Wilkins, J. A., and Chapman, H. A. (1999) A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J. Cell Biol. 144, 1285-1294
    • (1999) J. Cell Biol. , vol.144 , pp. 1285-1294
    • Wei, Y.1    Yang, X.2    Liu, Q.3    Wilkins, J.A.4    Chapman, H.A.5
  • 44
    • 0742305342 scopus 로고    scopus 로고
    • Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization
    • Upla, P., Marjomäki, V., Kankaanpää, P., Ivaska, J., Hyypiä, T., Van Der Goot, F. G., and Heino, J. (2004) Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. Mol. Biol. Cell 15, 625-636
    • (2004) Mol. Biol. Cell , vol.15 , pp. 625-636
    • Upla, P.1    Marjomäki, V.2    Kankaanpää, P.3    Ivaska, J.4    Hyypiä, T.5    Van Der Goot, F.G.6    Heino, J.7
  • 45
    • 77949528042 scopus 로고    scopus 로고
    • Caveolae act as membrane reserves which limit mechanosensitive I(Cl,swell) channel activation during swelling in the rat ventricular myocyte
    • Kozera, L., White, E., and Calaghan, S. (2009) Caveolae act as membrane reserves which limit mechanosensitive I(Cl,swell) channel activation during swelling in the rat ventricular myocyte. PLoS ONE 4, e8312
    • (2009) PLoS ONE , vol.4
    • Kozera, L.1    White, E.2    Calaghan, S.3
  • 47
    • 0038364029 scopus 로고    scopus 로고
    • Effects of acute ventricular volume manipulation on in situ cardiomyocyte cell membrane configuration
    • Kohl, P., Cooper, P. J., and Holloway, H. (2003) Effects of acute ventricular volume manipulation on in situ cardiomyocyte cell membrane configuration. Prog. Biophys. Mol. Biol. 82, 221-227
    • (2003) Prog. Biophys. Mol. Biol. , vol.82 , pp. 221-227
    • Kohl, P.1    Cooper, P.J.2    Holloway, H.3
  • 48
    • 34447125096 scopus 로고    scopus 로고
    • Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization
    • Lange, K., Kammerer, M., Hegi, M. E., Grotegut, S., Dittmann, A., Huang, W., Fluri, E., Yip, G. W., Götte, M., Ruiz, C., and Orend, G. (2007) Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization. Cancer Res. 67, 6163-6173
    • (2007) Cancer Res. , vol.67 , pp. 6163-6173
    • Lange, K.1    Kammerer, M.2    Hegi, M.E.3    Grotegut, S.4    Dittmann, A.5    Huang, W.6    Fluri, E.7    Yip, G.W.8    Götte, M.9    Ruiz, C.10    Orend, G.11
  • 49
    • 34147151018 scopus 로고    scopus 로고
    • Differential signaling and hypertrophic responses in cyclically stretched vs endothelin-1 stimulated neonatal rat cardiomyocytes
    • De Jonge, H. W., Dekkers, D. H., Houtsmuller, A. B., Sharma, H. S., and Lamers, J. M. (2007) Differential signaling and hypertrophic responses in cyclically stretched vs endothelin-1 stimulated neonatal rat cardiomyocytes. Cell Biochem. Biophys. 47, 21-32
    • (2007) Cell Biochem. Biophys. , vol.47 , pp. 21-32
    • De Jonge, H.W.1    Dekkers, D.H.2    Houtsmuller, A.B.3    Sharma, H.S.4    Lamers, J.M.5
  • 50
    • 11144231268 scopus 로고    scopus 로고
    • Transgenic expression of alpha7-beta1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice
    • Burkin, D. J., Wallace, G. Q., Milner, D. J., Chaney, E. J., Mulligan, J. A., and Kaufman, S. J. (2005) Transgenic expression of alpha7-beta1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice. Am. J. Pathol. 166, 253-263
    • (2005) Am. J. Pathol. , vol.166 , pp. 253-263
    • Burkin, D.J.1    Wallace, G.Q.2    Milner, D.J.3    Chaney, E.J.4    Mulligan, J.A.5    Kaufman, S.J.6
  • 51
    • 33745209452 scopus 로고    scopus 로고
    • Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin
    • Swaney, J. S., Patel, H. H., Yokoyama, U., Head, B. P., Roth, D. M., and Insel, P. A. (2006) Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J. Biol. Chem. 281, 17173-17179
    • (2006) J. Biol. Chem. , vol.281 , pp. 17173-17179
    • Swaney, J.S.1    Patel, H.H.2    Yokoyama, U.3    Head, B.P.4    Roth, D.M.5    Insel, P.A.6
  • 52
    • 41149124594 scopus 로고    scopus 로고
    • Caveolae as organizers of pharmacologically relevant signal transduction molecules
    • Patel, H. H., Murray, F., and Insel, P. A. (2008) Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu. Rev. Pharmacol. Toxicol. 48, 359-391
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 359-391
    • Patel, H.H.1    Murray, F.2    Insel, P.A.3
  • 53
    • 0037072827 scopus 로고    scopus 로고
    • Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass heterooligomer with caveolin-1
    • Lee, H., Park, D. S., Wang, X. B., Scherer, P. E., Schwartz, P. E., and Lisanti, M. P. (2002) Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass heterooligomer with caveolin-1. J. Biol. Chem. 277, 34556-34567
    • (2002) J. Biol. Chem. , vol.277 , pp. 34556-34567
    • Lee, H.1    Park, D.S.2    Wang, X.B.3    Scherer, P.E.4    Schwartz, P.E.5    Lisanti, M.P.6
  • 54
    • 0031058040 scopus 로고    scopus 로고
    • Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium
    • Kuppuswamy, D., Kerr, C., Narishige, T., Kasi, V. S., Menick, D. R., and Cooper IV, G. (1997) Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium. J. Biol. Chem. 272, 4500-4508
    • (1997) J. Biol. Chem. , vol.272 , pp. 4500-4508
    • Kuppuswamy, D.1    Kerr, C.2    Narishige, T.3    Kasi, V.S.4    Menick, D.R.5    Cooper, G.6
  • 55
    • 0042733080 scopus 로고    scopus 로고
    • Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: Cytoskeletal regulation of ERK translocation
    • Kawamura, S., Miyamoto, S., and Brown, J. H. (2003) Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J. Biol. Chem. 278, 31111-31117
    • (2003) J. Biol. Chem. , vol.278 , pp. 31111-31117
    • Kawamura, S.1    Miyamoto, S.2    Brown, J.H.3
  • 56
    • 34447500137 scopus 로고    scopus 로고
    • Stretch-induced MAP kinase activation in cardiac myocytes: Differential regulation through beta1-integrin and focal adhesion kinase
    • Lal, H., Verma, S. K., Smith, M., Guleria, R. S., Lu, G., Foster, D. M., and Dostal, D. E. (2007) Stretch-induced MAP kinase activation in cardiac myocytes: differential regulation through beta1-integrin and focal adhesion kinase. J. Mol. Cell. Cardiol. 43, 137-147
    • (2007) J. Mol. Cell. Cardiol. , vol.43 , pp. 137-147
    • Lal, H.1    Verma, S.K.2    Smith, M.3    Guleria, R.S.4    Lu, G.5    Foster, D.M.6    Dostal, D.E.7
  • 57
    • 0042266791 scopus 로고    scopus 로고
    • Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes
    • Torsoni, A. S., Constancio, S. S., Nadruz, W., Jr., Hanks, S. K., and Franchini, K. G. (2003) Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circ. Res. 93, 140-147
    • (2003) Circ. Res. , vol.93 , pp. 140-147
    • Torsoni, A.S.1    Constancio, S.S.2    Nadruz, W.3    Hanks, S.K.4    Franchini, K.G.5
  • 58
    • 15444375974 scopus 로고    scopus 로고
    • Reduction of caveolin-3 expression does not inhibit stretch-induced phosphorylation of ERK2 in skeletal muscle myotubes
    • Bellott, A. C., Patel, K. C., and Burkholder, T. J. (2005) Reduction of caveolin-3 expression does not inhibit stretch-induced phosphorylation of ERK2 in skeletal muscle myotubes. J. Appl. Physiol. 98, 1554-1561
    • (2005) J. Appl. Physiol. , vol.98 , pp. 1554-1561
    • Bellott, A.C.1    Patel, K.C.2    Burkholder, T.J.3


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