Tandem mass spectrometric determination of atypical 3β-hydroxy-Δ5-bile acids in patients with 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency: Application to diagnosis and monitoring of bile acid therapeutic response

Clinical Chemistry

Volumn 61, Issue 7, 2015, Pages 955-963

  Zhang, Wujuan ^a   Jha, Pinky ^a   Wolfe, Brian ^a   Gioiello, Antimo ^b   Pellicciari, Roberto ^b   Wang, Jianshe ^c   Heubi, James ^a   Setchell, Kenneth D R ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF PERUGIA   (Italy)

^c CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 BETA HYDROXY DELTA 5 BILE ACID; 3 BETA HYDROXY DELTA 5 CARBON 27 STEROID REDUCTASE; AMINOTRANSFERASE; BILE ACID; STEROID REDUCTASE; UNCLASSIFIED DRUG; 3 BETA-HYDROXY-DELTA 5-C(27)-STEROID DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3BETA,7BETA-DIHYDROXY-5-CHOLEN-24-OIC ACID; CHOLIC ACID; CHOLIC ACID DERIVATIVE; SULFATE;

3 BETA HYDROXY DELTA 5 CARBON 27 STEROID REDUCTASE DEFICIENCY; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BILE ACID SYNTHESIS; COLLISIONALLY ACTIVATED DISSOCIATION; CONJUGATION; CONTROLLED STUDY; DISORDERS OF LIPID METABOLISM; DRUG DOSE TITRATION; EARLY DIAGNOSIS; ELECTROSPRAY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; GENETIC DISORDER; HUMAN; HYDROLYSIS; KIDNEY CONCENTRATING CAPACITY; LIMIT OF QUANTITATION; LIVER DISEASE; NEGATIVE FEEDBACK; RANDOMIZED CONTROLLED TRIAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIGNAL NOISE RATIO; TANDEM MASS SPECTROMETRY; URINALYSIS; URINARY EXCRETION; CHEMISTRY; CHILD; CHOLESTASIS; DEFICIENCY; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION STUDY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; METABOLISM; METABOLISM, INBORN ERRORS; NEWBORN; PRESCHOOL CHILD; PROCEDURES; REPRODUCIBILITY; URINE;

3-HYDROXYSTEROID DEHYDROGENASES; BILE ACIDS AND SALTS; CHILD; CHILD, PRESCHOOL; CHOLESTASIS; CHOLIC ACID; CHOLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INFANT, NEWBORN; LIMIT OF DETECTION; METABOLISM, INBORN ERRORS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFATES; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 84937393649     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2015.238238     Document Type: Article

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