Ascorbic acid abrogates microparticle generation and vascular injuries associated with high-pressure exposure

Journal of Applied Physiology

Volumn 119, Issue 1, 2015, Pages 77-82

  Yang, Ming ^a   Bhopale, Veena M ^a   Thom, Stephen R ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Decompression; Microparticles; Neutrophil activation; Oxidative stress

Indexed keywords

ANTIGEN; ANTIOXIDANT; ASCORBIC ACID; ENZYME INHIBITOR; LIPOCORTIN 5; PHOSPHATIDYLSERINE;

AIR PRESSURE; ANIMAL; BIOSYNTHESIS; BLOOD VESSEL; C57BL MOUSE; CAPILLARY PERMEABILITY; DECOMPRESSION SICKNESS; DRUG EFFECTS; LEUKOCYTE ACTIVATION; MEMBRANE MICROPARTICLE; METABOLISM; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; VEGETARIAN DIET;

AIR PRESSURE; ANIMALS; ANNEXIN A5; ANTIGENS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD VESSELS; CAPILLARY PERMEABILITY; CELL-DERIVED MICROPARTICLES; DECOMPRESSION SICKNESS; DIET, VEGETARIAN; ENZYME INHIBITORS; MICE; MICE, INBRED C57BL; NEUTROPHIL ACTIVATION; PHOSPHATIDYLSERINES;

EID: 84937219029     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00183.2015     Document Type: Article

References (32)

1. Eftedal I, Ljubkovic M, Flatberg A, Jorgensen A, Brubakk AO, Dujic Z. Acute and potentially persistent effects of scuba diving on the blood transcriptome of experienced divers. Physiol Genomics 45: 965-972, 2013.
2. Eftedal OS, Lydersen S, Brubakk AO. The relationship between venous gas bubbles and adverse effects of decompression after air dives. Undersea Hyperb Med 34: 99-105, 2007.
3. Ferrer MD, Sureda A, Batle JM, Romaguera D, Tauler P, Tur JA, Pons A. Scuba diving enhances endogenous antioxidant defenses in lymphocytes and neutrophils. Free Radic Res 41: 274-281, 2007.
4. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86: 6377-6381, 1989.
5. Jackson TS, Xu A, Vita JA, Keaney JF. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 83: 916-922, 1998.
6. Ljubkovic M, Dujic Z, Mollerlokken A, Bakovic S, Obad A, Breskovic T, Brubakk AO. Venous and arterial bubbles at rest after no-decompression air dives. Med Sci Sports Exerc 43: 990-995, 2011.
7. Ljubkovic M, Marinovic J, Obad A, Breskovic T, Gaustad SE, Dujic Z. High incidence of venous and arterial gas emboli at rest after trimix diving without protocol violations. J Appl Physiol 109: 1670-1674, 2010.
8. Madden D, Thom SR, Milovanova TN, Yang M, Bhopale VM, Ljubkovic M, Dujic Z. Exercise before SCUBA diving ameliorates decompression-induced neutrophil activation. Med Sci Sports Exerc 46: 1928-1935, 2014.
9. Madden D, Thom SR, Yang M, Bhopale VM, Milovanova TN, Ljubkovic M, Dujic Z. High intensity cycling before SCUBA diving reduces post-decompression microparticle production and neutrophil activation. Eur J Appl Physiol 114: 1955-1961, 2014.
10. Madden LA, Chrismas BC, Mellor D, Vince RV, Midgley AW, McNaughton LR, Atkins SL, Laden G. Endothelial function and stress response after simulated dives to 18 msw breathing air or oxygen. Aviat Space Environ Med 81: 41-51, 2010.
11. Morabito C, Bosco G, Pilla R, Corona C, Mancinelli R, Yang Z, Camporesi EM, Fano G, Mariggio MA. Effect of pre-breathing oxygen at different depth on oxidative status and calcium concentration in lymphocytes of scuba divers. Acta Physiol Scand 202: 69-78, 2011.
12. Morel O, Jesel L, Hugel B, Douchet MP, Zupan M, Chauvin M, Freyssinet JM, Toti F. Protective effects of vitamin C on endothelium damage and platelet activation during myocardial infarction in patients with sustained generation of circulating microparticles. J Thromb Haemost 1: 171-177, 2003.
13. Obad A, Palada I, Valic Z, Ivancev V, Bakovic D, Wisloff U, Brubakk AO, Dujic Z. The effects of acute oral antioxidants on diving-induced alterations in human cardiovascular function. J Physiol 578: 859-870, 2007.
14. Obad A, Valic Z, Palada I, Brubakk AO, Modun D, Dujic Z. Antioxidant pretreatment and reduced arterial endothelial dysfunction after diving. Aviat Space Environ Med 78: 1114-1120, 2007.
15. Pleiner J, Schaller G, Mittermayer F, Marsik C, MacAllister RJ, Kapiotis S, Ziegler S, Ferlitsch A, Wolzt M. Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion. Atherosclerosis 197: 383-391, 2008.
16. Pontier JM, Gempp E, Ignatescu M. Blood platelet-derived microparticles release and bubble formation after an open-sea dive. Appl Physiol Nutr Metab 37: 1-5, 2012.
17. Rauma AL, Mykkanen H. Antioxidant status in vegetarians versus omnivores. Nutrition 16: 111-119, 2000.
18. Rossig L, Hoffmann J, Hugel B, Mallat Z, Haase A, Freyssinet JM, Tadgui A, Aicher A, Zeiher AM, Dimmeler S. Vitamin C inhibits endothelial cell apoptosis in congestive failure. Circulation 104: 2182-2187, 2001.
19. Squadrito GL, Jin X, Pryor WA. Stopped-flow kinetic study of the reaction of ascorbic acid with peroxynitrite. Arch Biochem Biophys 322: 53-59, 1995.
20. Stowell SR, Smith NH, Zimring JC, Fu X, Palmer AF, Fontes J, Banerjee U, Yazer MH. Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization. Transfusion 53: 2248-2257, 2013.
21. Sureda A, Batle JM, Capo X, Martorell M, Cordova A, Tur JA, Pons A. Scuba diving induces nitric oxide synthesis and the expression of inflammatory and regulatory genes of the immune response in neutrophils. Physiol Genomics 46: 647-654, 2014.
22. Sureda A, Batle JM, Ferrer MD, Mastre-Alfaro A, Tur JA, Pons A. Scuba diving activates vascular antioxidant system. Int J Sports Med 33: 531-536, 2012.
23. Sureda A, Ferrer MD, Batle JM, Tauler P, Tur JA, Pons A. Scuba diving increases erythrocyte and plasma antioxidant defenses and spares NO without oxidative damage. Med Sci Sports Exerc 41: 1271-1276, 2009.
24. Szeto YT, Kwok TCY, Benzie FF. Effects of a long-term vegetarian diet on biomarkers of antioxidant status and cardiovascular disease risk. Nutrition 20: 863-866, 2004.
25. Thom SR, Bhopale VM, Yang M. Neutrophils generate microparticles during exposure to inert gases due to cytoskeletal oxidative stress. J Biol Chem 289: 18831-18845, 2014.
26. Thom SR, Milovanova TN, Bogush M, Bhopale VM, Yang M, Bushmann K, Pollock NW, Ljubkovic M, Denoble P, Dujic Z. Microparticle production, neutrophil activation and intravascular bubbles following open-water SCUBA diving. J Appl Physiol 112: 1268-1278, 2012.
27. Thom SR, Milovanova TN, Bogush M, Yang M, Bhopale VM, Pollock NW, Ljubkovic M, Denoble P, Madden D, Lozo M, Dujic Z. Bubbles, microparticles and neutrophil activation: Changes with exercise level and breathing gas during open-water SCUBA diving. J Appl Physiol 114: 1396-1405, 2013.
28. Thom SR, Yang M, Bhopale VM, Huang S, Milovanova TN. Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries. J Appl Physiol 110: 340-351, 2011.
29. Thom SR, Yang M, Bhopale VM, Milovanova TN, Bogush M, Buerk DG. Intra-microparticle nitrogen dioxide is a bubble nucleation site leading to decompression-induced neutrophil activation and vascular injury. J Appl Physiol 114: 550-558, 2013.
30. Vince RV, McNaughton LR, Taylor L, Midgley AW, Laden G, Madden LA. Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives. Eur J Appl Physiol 105: 507-513, 2009.
31. Yang M, Kosterin P, Salzberg BM, Milovanova TN, Bhopale VM, Thom SR. Microparticles generated by decompression stress cause central nervous system injury manifested as neurohypophiseal terminal action potential broadening. J Appl Physiol 115: 1481-1486, 2013.
32. Yang M, Milovanova TN, Bogush M, Uzan G, Bhopale VM, Thom SR. Microparticle enlargement and altered surface proteins after air decompression are associated with inflammatory vascular injuries. J Appl Physiol 112: 204-211, 2012.