메뉴 건너뛰기




Volumn 25, Issue 8, 2015, Pages 931-937

Advances in the treatment of chronic wounds: A patent review

Author keywords

Bone marrow derived mesenchymal stem cells; Connexin43; CYP11B1; Decubitus; Diabetes; Elastase; Growth factors; Matrix metalloproteinases; Prolyl 4 hydroxylase; Wound healing

Indexed keywords

CONNEXIN 43 INHIBITOR; CYP11B1 INHIBITOR; ELASTASE INHIBITOR; ENZYME INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; OXYGENASE INHIBITOR; PROLYL 4 HYDROXYLASE INHIBITOR; PROTEIN INHIBITOR; RECOMBINANT GROWTH FACTOR; UNCLASSIFIED DRUG; BIOLOGICAL FACTOR;

EID: 84937214923     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2015.1045879     Document Type: Review
Times cited : (46)

References (63)
  • 1
    • 84888132076 scopus 로고    scopus 로고
    • US-National institutes of Healthfunded research for cutaneous wounds in 2012
    • Richmond NA, Lamel SA, Davidson JM, et al. US-National institutes of Healthfunded research for cutaneous wounds in 2012. Wound Repair Reg 2013;21:789-92
    • (2013) Wound Repair Reg , vol.21 , pp. 789-792
    • Richmond, N.A.1    Lamel, S.A.2    Davidson, J.M.3
  • 2
    • 84934968330 scopus 로고    scopus 로고
    • Preclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds
    • [Epub ahead of print]
    • Heublein H, Bader A, Giri S. Preclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds. Drug Discov Today 2015. [Epub ahead of print]
    • (2015) Drug Discov Today
    • Heublein, H.1    Bader, A.2    Giri, S.3
  • 3
    • 84911879917 scopus 로고    scopus 로고
    • Advances in skin grafting and treatment of cutaneous wounds
    • Sun BK, Siprashvilli Z, Khavari PA. Advances in skin grafting and treatment of cutaneous wounds. Science 2014;346:941-5
    • (2014) Science , vol.346 , pp. 941-945
    • Sun, B.K.1    Siprashvilli, Z.2    Khavari, P.A.3
  • 4
    • 27744448125 scopus 로고    scopus 로고
    • Wound healing and its impairment in the diabetic foot
    • Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;366:1736-43
    • (2005) Lancet , vol.366 , pp. 1736-1743
    • Falanga, V.1
  • 7
    • 84886601180 scopus 로고    scopus 로고
    • Steroidogenesis in the skin: Implication for local immune functions
    • Slominski A, Zbytek B, Nikolakis G, et al. Steroidogenesis in the skin: implication for local immune functions. J Steroid Biochem Mol Biol 2013;137:107-23
    • (2013) J Steroid Biochem Mol Biol , vol.137 , pp. 107-123
    • Slominski, A.1    Zbytek, B.2    Nikolakis, G.3
  • 8
    • 84901490008 scopus 로고    scopus 로고
    • Cutaneous glucocorticosteroidogenesis: Securing local homeostasis and the skin integrity
    • Slominski AT, Manna PR, Tuckey RC. Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity. Exp Dermatol 2014;23:369-74
    • (2014) Exp Dermatol , vol.23 , pp. 369-374
    • Slominski, A.T.1    Manna, P.R.2    Tuckey, R.C.3
  • 9
    • 79953184635 scopus 로고    scopus 로고
    • Cortisol synthesis in epidermis is induced by IL-1 and tissue injury
    • Vukelic S, Stojadinovic O, Pastar I, et al. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem 2011;286:10265-75
    • (2011) J Biol Chem , vol.286 , pp. 10265-10275
    • Vukelic, S.1    Stojadinovic, O.2    Pastar, I.3
  • 10
  • 11
    • 84925341588 scopus 로고    scopus 로고
    • Chronic wound repair and healing in older adults: Current status and future research
    • Gould L, Abadir P, Brem H, et al. Chronic wound repair and healing in older adults: current status and future research. Wound Rep Regen 2015;63(3):427-38
    • (2015) Wound Rep Regen , vol.63 , Issue.3 , pp. 427-438
    • Gould, L.1    Abadir, P.2    Brem, H.3
  • 12
    • 84908895813 scopus 로고    scopus 로고
    • Epithelialization in wound healing: A comprehensive review
    • Pastar I, Stojadinovic O, Yin NC, et al. Epithelialization in wound healing: A comprehensive review. Adv Wound Care 2014;3:445-64
    • (2014) Adv Wound Care , vol.3 , pp. 445-464
    • Pastar, I.1    Stojadinovic, O.2    Yin, N.C.3
  • 13
    • 13544259736 scopus 로고    scopus 로고
    • Cellular and molecular facets of keratinocyte reepithelization during wound healing
    • Santoro MM, Gaudino G. Cellular and molecular facets of keratinocyte reepithelization during wound healing. Exp Cell Res 2005;304:274-86
    • (2005) Exp Cell Res , vol.304 , pp. 274-286
    • Santoro, M.M.1    Gaudino, G.2
  • 14
    • 84858126311 scopus 로고    scopus 로고
    • The role of endogenous enzymes in chronic wounds: A focus on the implications of aberrant levels of both host and bacterial proteases in wound healing
    • Carty SM, Cochrane CA, Clegg PD, Percival SL. The role of endogenous enzymes in chronic wounds: A focus on the implications of aberrant levels of both host and bacterial proteases in wound healing. Wound Rep Reg 2012;20:125-36
    • (2012) Wound Rep Reg , vol.20 , pp. 125-136
    • Carty, S.M.1    Cochrane, C.A.2    Clegg, P.D.3    Percival, S.L.4
  • 15
    • 84878529977 scopus 로고    scopus 로고
    • Gap junction remodeling in skin repair following wounding and disease
    • Churko JM, Laird DW. Gap junction remodeling in skin repair following wounding and disease. Physiology 2013;28:190-8
    • (2013) Physiology , vol.28 , pp. 190-198
    • Churko, J.M.1    Laird, D.W.2
  • 16
  • 17
    • 84908887420 scopus 로고    scopus 로고
    • Stress-induced hormones cortisol and epinephrine impair wound epithelization
    • Stojadinovic O, Gordon KA, Lebrun E, Tomic-Canic M. Stress-induced hormones cortisol and epinephrine impair wound epithelization. Adv Wound Care 2012;1:29-35
    • (2012) Adv Wound Care , vol.1 , pp. 29-35
    • Stojadinovic, O.1    Gordon, K.A.2    Lebrun, E.3    Tomic-Canic, M.4
  • 18
    • 84860716906 scopus 로고    scopus 로고
    • Dexamethasone inhibits TGF-2-induced migration of human lens epithelial cells: Implications for posterior capsule opacification prevention
    • Yao J, Yang W, Liu Y, et al. Dexamethasone inhibits TGF-2-induced migration of human lens epithelial cells: implications for posterior capsule opacification prevention. Mol Med Reports 2012;5:1509-13
    • (2012) Mol Med Reports , vol.5 , pp. 1509-1513
    • Yao, J.1    Yang, W.2    Liu, Y.3
  • 19
    • 84867021930 scopus 로고    scopus 로고
    • Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis
    • Shikatani EA, Trifonova A, Mandel ER, et al. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS ONE 2012;7:e46625
    • (2012) PLoS ONE , vol.7 , pp. e46625
    • Shikatani, E.A.1    Trifonova, A.2    Mandel, E.R.3
  • 20
    • 84879638689 scopus 로고    scopus 로고
    • 11b-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects
    • Tiganescu A, Tahrani AA, Morgan SA, et al. 11b-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. J Clin Invest 2013;123:3051-60
    • (2013) J Clin Invest , vol.123 , pp. 3051-3060
    • Tiganescu, A.1    Tahrani, A.A.2    Morgan, S.A.3
  • 21
    • 84882824040 scopus 로고    scopus 로고
    • Corticosteroids and wound healing: Clinical considerations in the perioperative period
    • Wang AS, Armstrong EJ, Armstrong AW. Corticosteroids and wound healing: clinical considerations in the perioperative period. Am J Surg 2013;206:410-17
    • (2013) Am J Surg , vol.206 , pp. 410-417
    • Wang, A.S.1    Armstrong, E.J.2    Armstrong, A.W.3
  • 22
    • 80051710067 scopus 로고    scopus 로고
    • Optimization of the first selective steroid-11b-hydroxylase (CYP11B1) inhibitors for the treatment of cortisol dependent diseases
    • Hille UE, Zimmer C, Haupenthal J, Hartmann RW. Optimization of the first selective steroid-11b-hydroxylase (CYP11B1) inhibitors for the treatment of cortisol dependent diseases. ACS Med Chem. Lett 2011;2:559-64
    • (2011) ACS Med Chem. Lett , vol.2 , pp. 559-564
    • Hille, U.E.1    Zimmer, C.2    Haupenthal, J.3    Hartmann, R.W.4
  • 23
    • 84880174933 scopus 로고    scopus 로고
    • Cushing's syndrome: Development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)-pyridine type
    • Emmerich J, Hu Q, Hanke N, Hartmann RW. Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)-pyridine type. J Med Chem 2013;56:6022-32
    • (2013) J Med Chem , vol.56 , pp. 6022-6032
    • Emmerich, J.1    Hu, Q.2    Hanke, N.3    Hartmann, R.W.4
  • 24
    • 84907462346 scopus 로고    scopus 로고
    • Potent 11-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing
    • Zhu W, Hu Q, Hanke N, et al. Potent 11-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing. J Med Chem 2014;57:7811-17
    • (2014) J Med Chem , vol.57 , pp. 7811-7817
    • Zhu, W.1    Hu, Q.2    Hanke, N.3
  • 25
    • 84962058168 scopus 로고    scopus 로고
    • Selective Cyp11b1 inhibitors for the treatment of cortisol dependent diseases
    • Hartmann R, Hille U, Hu Q, et al. Selective Cyp11b1 inhibitors for the treatment of cortisol dependent diseases. WO2012052540 A1; 2012
    • WO2012052540 A1 , vol.2012
    • Hartmann, R.1    Hille, U.2    Hu, Q.3
  • 26
    • 84937236193 scopus 로고    scopus 로고
    • 11b-Hydroxysteroid dehydrogenases
    • Bionetworks GmbH
    • Bionetworks GmbH. Wilckens T. 11b-Hydroxysteroid dehydrogenases. WO 2006097337 A2; 2006
    • (2006) WO 2006097337 A2
    • Wilckens, T.1
  • 27
    • 84937236194 scopus 로고    scopus 로고
    • Substituted azole aromatic heterocycles as inhibitors of 11b-HSD-1
    • Amgen Inc.
    • Amgen Inc. Biovitrum Ab. Substituted azole aromatic heterocycles as inhibitors of 11b-HSD-1. WO2008011453 A2; 2008
    • (2008) WO2008011453 A2
    • Biovitrum, A.B.1
  • 28
    • 84937236195 scopus 로고    scopus 로고
    • Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1
    • Amgen Inc.
    • Amgen Inc. Biovitrum. Ab. Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1. CA2630718 A1; 2007
    • (2007) CA2630718 A1
    • Biovitrum, A.B.1
  • 29
    • 84937236196 scopus 로고    scopus 로고
    • Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
    • Vitae Pharmaceuticals Inc.
    • Vitae Pharmaceuticals Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. WO2010091067 A2; 2010
    • (2010) WO2010091067 A2
  • 30
    • 43749094102 scopus 로고    scopus 로고
    • First-class delivery:Getting growth factors to their destination
    • Davidson JM. First-class delivery: getting growth factors to their destination. J Invest Dermatol 2008;128:1360-2
    • (2008) J Invest Dermatol , vol.128 , pp. 1360-1362
    • Davidson, J.M.1
  • 31
    • 77953958239 scopus 로고    scopus 로고
    • Application of a PDGF-containing novel gel for ctaneous wound healing
    • Judith R, Nithya M, Rose C, et al. Application of a PDGF-containing novel gel for ctaneous wound healing. Life Sci 2010;87:1-8
    • (2010) Life Sci , vol.87 , pp. 1-8
    • Judith, R.1    Nithya, M.2    Rose, C.3
  • 32
    • 33846903306 scopus 로고    scopus 로고
    • Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats
    • Cheng B, Liu HW, Fu XB, et al. Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats. J Dermatol Sci 2007;45:193-201
    • (2007) J Dermatol Sci , vol.45 , pp. 193-201
    • Cheng, B.1    Liu, H.W.2    Fu, X.B.3
  • 33
    • 38849118281 scopus 로고    scopus 로고
    • Collagen membranes loaded with collagen-binding human PDGF-BB accelerate wound healing in a rabbit dermal ischemic ulcer model
    • Sun W, Lin H, Xie H, et al. Collagen membranes loaded with collagen-binding human PDGF-BB accelerate wound healing in a rabbit dermal ischemic ulcer model. Growth Fact 2007;25:309-18
    • (2007) Growth Fact , vol.25 , pp. 309-318
    • Sun, W.1    Lin, H.2    Xie, H.3
  • 34
    • 84937236197 scopus 로고    scopus 로고
    • Methods of stimulating wound healing by administration of vascular endothelial growth factor D (VEGF-D)
    • Vegenics Pty Ltd
    • Vegenics Pty Ltd. Methods of stimulating wound healing by administration of vascular endothelial growth factor D (VEGF-D). US8227410 B2; 2012
    • US8227410 B2 , vol.2012
  • 35
    • 84937236198 scopus 로고    scopus 로고
    • Novel peptides for wound healing
    • Gene Signal International SA.
    • Gene Signal International SA. Novel peptides for wound healing. US20110306545 A1; 2011
    • (2011) US20110306545 A1
  • 36
    • 84937236199 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors
    • Ranbaxy Laboratories Ltd.
    • Ranbaxy Laboratories Ltd. Matrix metalloproteinase inhibitors. US8846910 B2; 2014
    • (2014) US8846910 B2
  • 37
    • 84962081718 scopus 로고    scopus 로고
    • Thiazol derivatives as pro-matrix metalloproteinase inhibitors
    • Janssen Pharmaceutica NV. Thiazol derivatives as pro-matrix metalloproteinase inhibitors. WO2012162468 A1; 2012
    • (2012) WO2012162468 A1
    • Janssen Pharmaceutica, N.V.1
  • 38
    • 84937236201 scopus 로고    scopus 로고
    • Metalloproteinase 9 and metalloproteinase 2 binding proteins
    • Dyax Corp
    • Dyax Corp. Metalloproteinase 9 and metalloproteinase 2 binding proteins. US8013125 B2. 2011
    • (2011) US8013125 B2.
  • 39
    • 84937236202 scopus 로고    scopus 로고
    • Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
    • Amgen
    • Amgen. Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods. US20140228540 A1; 2014
    • (2014) US20140228540 A1
  • 40
    • 84937236203 scopus 로고    scopus 로고
    • Metalloproteinase inhibitors for wound healing
    • Kimberly-Clark Worldwide, Inc
    • Kimberly-Clark Worldwide, Inc. Metalloproteinase inhibitors for wound healing. US7186693 B2; 2007
    • (2007) US7186693 B2
  • 41
    • 84904749172 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factor in wound healing
    • Hong WX, Hu MS, Esquivel M, et al. The role of hypoxia-inducible factor in wound healing. Adv Wound Care 2014;3:390-9
    • (2014) Adv Wound Care , vol.3 , pp. 390-399
    • Hong, W.X.1    Hu, M.S.2    Esquivel, M.3
  • 42
    • 84937236204 scopus 로고    scopus 로고
    • Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors
    • Bayer Intellectual Property GmbH
    • Bayer Intellectual Property GmbH. Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors. US8524699 B2; 2013
    • US8524699 B2 , vol.2013
  • 43
    • 84937236205 scopus 로고    scopus 로고
    • Diazaquinolones that inhibit prolyl hydroxylase activity
    • Amgen.
    • Amgen. Diazaquinolones that inhibit prolyl hydroxylase activity. US8097620 B2; 2012
    • (2012) US8097620 B2
  • 44
    • 84937236206 scopus 로고    scopus 로고
    • Prolyl hydroxylase inhibitors
    • GlaxoSmithKline Llc.
    • GlaxoSmithKline Llc. Prolyl hydroxylase inhibitors. WO2010059552 A1; 2010
    • (2010) WO2010059552 A1
  • 45
    • 84962120777 scopus 로고    scopus 로고
    • Benzoimidazole glycinamides as prolyl hydroxylase inhibitors
    • Janssen Pharmaceutica N. V. Benzoimidazole glycinamides as prolyl hydroxylase inhibitors. WO2009134754 A1; 2009
    • (2009) WO2009134754 A1
    • Janssen Pharmaceutica, N.V.1
  • 46
    • 84919457239 scopus 로고    scopus 로고
    • Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1
    • Ruthenborg RJ, Ban J-J, Wazir A, et al. Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1. Mol Cells 2014;37:637-43
    • (2014) Mol Cells , vol.37 , pp. 637-643
    • Ruthenborg, R.J.1    Ban, J.-J.2    Wazir, A.3
  • 47
    • 84875756145 scopus 로고    scopus 로고
    • Concise review: Role of mesenchymal stem cells in wound repair
    • Maxson S, Lopez EA, Yoo D, et al. Concise review: role of mesenchymal stem cells in wound repair. Stem Cells Trans Med 2012;1:142-9
    • (2012) Stem Cells Trans Med , vol.1 , pp. 142-149
    • Maxson, S.1    Lopez, E.A.2    Yoo, D.3
  • 48
    • 84872783947 scopus 로고    scopus 로고
    • Therapeutic potential of bone marrowderived mesenchymal stem cells for cutaneous wound healing
    • Chen JS, Wong VW, Gurtner GC. Therapeutic potential of bone marrowderived mesenchymal stem cells for cutaneous wound healing. Front Immun 2012;3:192
    • (2012) Front Immun , vol.3 , pp. 192
    • Chen, J.S.1    Wong, V.W.2    Gurtner, G.C.3
  • 49
    • 84901438924 scopus 로고    scopus 로고
    • Activity of mesenchymal stem cells in therapies for chronic skin wound healing
    • Nuschke A. Activity of mesenchymal stem cells in therapies for chronic skin wound healing. Organesis 2014;10:29-37
    • (2014) Organesis , vol.10 , pp. 29-37
    • Nuschke, A.1
  • 50
    • 84937236208 scopus 로고    scopus 로고
    • Cell therapy to improve wound healing and related compositions and methods
    • Cryo-Cell International, Inc
    • Cryo-Cell International, Inc. Cell therapy to improve wound healing and related compositions and methods. EP2553089 A1; 2013
    • EP2553089 A1 , vol.2013
  • 51
    • 84937236209 scopus 로고    scopus 로고
    • Mesenchymal stem cells and uses therefor
    • Mesoblast International Sarl.
    • Mesoblast International Sarl. Mesenchymal stem cells and uses therefor. US 2011/0318314 A1; 2011
    • (2011) US 2011/0318314 A1
  • 52
    • 84937236210 scopus 로고    scopus 로고
    • Stem cell, precursor cell, or target cellbased treatment of multi-organ failure and renal dysfunction
    • US Department of Veterans Affairs, University of Utah Research Foundation
    • US Department of Veterans Affairs, University of Utah Research Foundation. Stem cell, precursor cell, or target cellbased treatment of multi-organ failure and renal dysfunction. US20140086886 A1; 2014
    • (2014) US20140086886 A1
  • 53
    • 84937236211 scopus 로고    scopus 로고
    • Methods of culturing and expanding mesenchymal stem cells and isolated cell populations generated thereby
    • Gamida Cell Ltd.
    • Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells and isolated cell populations generated thereby. US20140023623 A1; 2014
    • (2014) US20140023623 A1
  • 54
    • 84855432805 scopus 로고    scopus 로고
    • Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications
    • Barros SC, Martins JA, Marcos JC, Cavaco-Paulo A. Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications. Enzym Micro Tec 2012;50:107-14
    • (2012) Enzym Micro Tec , vol.50 , pp. 107-114
    • Barros, S.C.1    Martins, J.A.2    Marcos, J.C.3    Cavaco-Paulo, A.4
  • 55
    • 84919784244 scopus 로고    scopus 로고
    • Proteases and delayed wound healing
    • Carty SM, Percival SL. Proteases and delayed wound healing. Adv Wound Care 2013;2:438-47
    • (2013) Adv Wound Care , vol.2 , pp. 438-447
    • Carty, S.M.1    Percival, S.L.2
  • 56
    • 84962127132 scopus 로고    scopus 로고
    • Methods to accelerate tissue and wound healing rates and reduce swelling and scar formation
    • Delano FA, Schonbein GW. Methods to accelerate tissue and wound healing rates and reduce swelling and scar formation. WO2011038417 A2; 2011
    • WO2011038417 A2 , vol.2011
    • Delano, F.A.1    Schonbein, G.W.2
  • 58
  • 59
    • 84866005644 scopus 로고    scopus 로고
    • Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds
    • Ormondo S, Chou C-Y, Goold L, et al. Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds. J Membr Biol 2012;245:381-8
    • (2012) J Membr Biol , vol.245 , pp. 381-388
    • Ormondo, S.1    Chou, C.-Y.2    Goold, L.3
  • 60
    • 84885649941 scopus 로고    scopus 로고
    • A connexin43 mimetic peptide promotes regenerative healing and improves mechanical properties in skin and heart
    • Ongstad EL, O'Quinn MP, Ghatnekar G. A connexin43 mimetic peptide promotes regenerative healing and improves mechanical properties in skin and heart. Adv Wound Care 2013;2:55-62
    • (2013) Adv Wound Care , vol.2 , pp. 55-62
    • Ongstad, E.L.1    O'quinn, M.P.2    Ghatnekar, G.3
  • 61
    • 84925956562 scopus 로고    scopus 로고
    • The effect of a connexin43. Based peptide on the healing of chronic venous leg ulcers: A multicenter, randomized trial
    • The first clinical data on Cx43 inhibitor to promote wound healing in chronic venous ulcer.
    • Ghatnekar GS, Grek CL, Armstrong DG, et al. The effect of a connexin43. based peptide on the healing of chronic venous leg ulcers: A multicenter, randomized trial. J Invest Dermatol 2015;135:289-98. The first clinical data on Cx43 inhibitor to promote wound healing in chronic venous ulcer.
    • (2015) J Invest Dermatol , vol.135 , pp. 289-298
    • Ghatnekar, G.S.1    Grek, C.L.2    Armstrong, D.G.3
  • 62
    • 84962118131 scopus 로고    scopus 로고
    • Compositions and methods for promoting wound healing and tissue regeneration
    • Gourdie R, Ghatnekar G, Jourdan J. Compositions and methods for promoting wound healing and tissue regeneration. EP2377546 A2; 2011
    • (2011) EP2377546 A2
    • Gourdie, R.1    Ghatnekar, G.2    Jourdan, J.3
  • 63
    • 84937236216 scopus 로고    scopus 로고
    • Anti-connexin compounds targeted to connexins and methods of use thereof
    • Coda Therapeutics Inc.
    • Coda Therapeutics Inc. Anti-connexin compounds targeted to connexins and methods of use thereof. US8815819; 2014
    • (2014) US8815819


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.