Lung mesenchymal cells function as an inductive microenvironment for human lung cancer propagating cells

European Journal of Cardio-thoracic Surgery

Volumn 46, Issue 6, 2014, Pages e103-e112

  Ampollini, Luca ^a   Madeddu, Denise ^a   Falco, Angela ^a   Frati, Caterina ^a   Lorusso, Bruno ^a   Graiani, Gallia ^a   Saccani, Francesca ^a   Gervasi, Andrea ^a   Rossetti, Pietro ^a   Bonomini, Sabrina ^a   Gnetti, Letizia ^a   Lagrasta, Costanza Annamaria ^a   Silini, Enrico Maria ^a   Quaini, Eugenio ^b   Petronini, Piergiorgio ^a   Alfieri, Roberta ^a   Rusca, Michele ^a   Carbognani, Paolo ^a   Quaini, Federico ^a  

^a UNIVERSITY HOSPITAL OF PARMA   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

Cancer stem cell niche; Lung cancer; Mesenchymal cells; Tumour microenvironment; Tumour xenografts

Indexed keywords

5' NUCLEOTIDASE; CD133 ANTIGEN; CD14 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; ENDOGLIN; EPITHELIAL MEMBRANE ANTIGEN; HERMES ANTIGEN; MICROSOMAL AMINOPEPTIDASE; OCTAMER TRANSCRIPTION FACTOR 4; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR SOX2;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL; LUNG CARCINOGENESIS; MAJOR CLINICAL STUDY; MALE; MESENCHYME CELL; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL LUNG CARCINOMA; TUMOR CELL INOCULATION; TUMOR DIFFERENTIATION; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CANCER STEM CELL; CANCER TRANSPLANTATION; CARCINOGENESIS; LUNG; LUNG TUMOR; MESENCHYMAL STROMA CELL; MIDDLE AGED; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; VERY ELDERLY; XENOGRAFT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CARCINOGENESIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; FEMALE; HETEROGRAFTS; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; TUMOR MICROENVIRONMENT;

EID: 84937197774     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezu359     Document Type: Article

References (25)

1. Pfister DG, Johnson DH, Azzoli CG, Sause W, Smith TJ, Baker S Jr et al. American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guide line. J Clin Oncol 2004;22:330-53.
2. Zarogoulidis K, Zarogoulidis P, Darwiche K, Boutsikou E, Machairiotis N, Tsakiridis K et al. Treatment of non-small cell lung cancer (NSCLC). J Thorac Dis 2013;5:S389-96.
3. Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV et al. Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer 2012;12:767-75.
4. Tirino V, Camerlingo R, Franco R, Malanga D, La Rocca A, Viglietto G et al. The role of CD133 in the identification and characterisation of tumourinitiating cells in non-small-cell lung cancer. Eur J Cardiothorac Surg 2009; 36:446-53.
5. Scadden DT. The stem-cell niche as an entity of action. Nature 2006;441: 1075-79.
6. Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B et al. A perivascular niche for brain tumor stem cells. Cancer Cell 2007;11:69-82.
7. Tozer GM, Kanthou C, Baguley BC. Disrupting tumour blood vessels. Nat Rev Cancer 2005;5:423-35.
8. Scherzed A, Hackenberg S, Radeloff A, Froelich K, Rak K, Hagen R et al. Human mesenchymal stem cells promote cancer motility and cytokine secretion in vitro. Cells Tissues Organs 2013;198:327-37.
9. Bremnes RM, Dønnem T, Al-Saad S, Al-Shibli K, Andersen S, Sirera R et al. The role of tumor stroma in cancer progression and prognosis. J Thorac Oncol 2011;6:209-17.
10. Gottschling S, Granzow M, Kuner R, Jauch A, Herpel E, Xu EC et al. Mesenchymal stem cells in non small cell lung cancer-different from others? Insight from comparative molecular and functional analyses. Lung Cancer 2013;80:19-29.
11. Fujita H, Ohuchida K, Mizumoto K, Nakata K, Yu J, Kayashima T et al. a-Smooth muscle actin expressing stroma promotes an aggressive tumour biology in pancreatic ductal adenocarcinoma. Pancreas 2010;39:1254-62.
12. Vihinen P, Kähäri VM. Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer 2002;99:157-66.
13. Calle EE, Kaaks RR. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579-91.
14. Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005;352:786-92.
15. Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-43.
16. Meads MB, Gatenby RA, Dalton WS. Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 2009;9:665-74.
17. Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F et al. Evidence for human lung stem cells. N Engl J Med 2011;364:1795-806.
18. Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010;464:852-7.
19. Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R et al. Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell 2012;149:1207-20.
20. Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Ann Rev Pathol 2006;1:119-50.
21. Sabatini F, Petecchia L, Tavian M, Jodon de Villeroché V, Rossi GA, Brouty-Boyé D. Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multiline-age differentiating potentialities. Lab Invest 2005;85:962-71.
22. Kolluri KK, Laurent GJ, Janes SM. Mesenchymal stem cells as vectors for lung cancer therapy. Respiration 2013;85:443-51.
23. Rossini A, Frati C, Lagrasta C, Graiani G, Scopece A, Cavalli S et al. Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin. Cardiovasc Res 2011;89:650-60.
24. Li L, Tian H, Chen Z, Yue W, Li S, Li W. Inhibition of lung cancer cell proliferation mediated by human mesenchymal stem cells. Acta Biochim Biophys Sin 2011;43:143-8.
25. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol 2014;15:178-96.