Effect of deworming on Th2 immune response during HIV-helminths co-infection

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Mulu, Andargachew ^a,b   Anagaw, Belay ^a   Gelaw, Aschalew ^a   Ota, Fuso ^c   Kassu, Afework ^a   Yifru, Sisay ^a  

^a UNIVERSITY OF GONDAR   (Ethiopia)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

ART; Deworming; Ethiopia; Helminths; IgE; Th2

Indexed keywords

ALBENDAZOLE; IMMUNOGLOBULIN E; PRAZIQUANTEL; ANTHELMINTIC AGENT;

ADULT; ANTIVIRAL THERAPY; ARTICLE; ASCARIS LUMBRICOIDES; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ENTAMOEBA HISTOLYTICA; ETHIOPIA; FEMALE; GIARDIA INTESTINALIS; HELMINTHIASIS; HOOKWORM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYMENOLEPIS NANA; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; NEMATODE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SINGLE DRUG DOSE; STRONGYLOIDE STERCORALIS; TAENIA SAGINATA; TH2 CELL; TREATMENT RESPONSE; TRICHURIS TRICHIURA; UNIVERSITY HOSPITAL; WORM EXPULSION; ANIMAL; BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; CYTOLOGY; HELMINTH; IMMUNOLOGY; LYMPHOCYTE COUNT; PARASITOLOGY; PROGNOSIS; TREATMENT OUTCOME; VIROLOGY; YOUNG ADULT;

ADULT; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COINFECTION; DISEASE PROGRESSION; ETHIOPIA; FEMALE; HELMINTHIASIS; HELMINTHS; HIV INFECTIONS; HUMANS; IMMUNOGLOBULIN E; LYMPHOCYTE COUNT; MALE; PROGNOSIS; PROSPECTIVE STUDIES; TH2 CELLS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84937197583     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0600-3     Document Type: Article

References (34)

1. MacDonald AS, Araujo MI, Pearce EJ (2002) Immunology of parasitic helminth infections. Infect Immun 70:427-433
2. Secord EA, Kleiner GI, Auci DL, Smith-Norowitz T, Chice S, Finkielstein A et al (1998) IgE against HIV proteins in clinically healthy children with HIV disease. J Allergy Clin Immunol 98:980-984
3. Park JH, Shin BC, Do BH, Oh JT, Lee JM, Kim SW et al (2002) Serum IgE levels in Korean patients with human immunodeficiency virus infection. Korean J Intern Med 17:88-93
4. Bentwich Z, Kalinkovich A, Weisman Z (1995) Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today 16:187-191
5. Kalinkovich A, Weisman Z, Bentwich Z (1995) Role of TH1 and TH2 in the pathogenesis of AIDS and various other diseases. Harefuah 128:228-233
6. Bentwich Z, Weisman Z, Moroz C, Bar-Yehuda S, Kalinkovich A (1996) Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infections? Clin Exp Immunol 103:239-243
7. Kalinkovich A, Weisman Z, Bentwich Z (1999) Chemokines and chemokine receptors: role in HIV infection. Immunol Lett 68:281-287
8. Bentwich Z, Maartens G, Torten D, Lal AA, Lal RB (2000) Concurrent infections and HIV pathogenesis. AIDS 14:2071-2081
9. + T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians. Clin Exp Immunol 132:113-119
10. Borkow G, Bentwich Z (2004) Symptomatic immune activation associated with symptomatic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Clin Microbiol Rev 17:1012-1030
11. Bentwich Z, Kalinkovich A, Weisman Z, Borkow G, Beyers N, Beyers AD et al (1999) Can eradication of helminthic infections change the face of AIDS and tuberculosis? Immunol Today 20:485-487
12. Brazille P, Dereuddre-Bosquet N, Leport C, Clayette P, Boyer O, Vildé JL et al (2003) Decreases in plasma TNF-alpha level and IFN-gamma mRNA level in peripheral blood mononuclear cells (PBMC) and an increase in IL-2 mRNA level in PBMC are associated with effective highly active antiretroviral therapy in HIV-infected patients. Clin Exp Immunol 131:304-311
13. ++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS 16:589-596
14. Kassu A, Mohammad A, Fujimaki Y, Moges F, Elias D, Mekonnen F et al (2004) Serum IgE levels of tuberculosis patients in a tropical setup with high prevalence of HIV and intestinal parasitoses. Clin Exp Immunol 138:122-127. doi: 10.1111/j.1365-2249.2004.02597.x
15. Gelaw A, Abate E, Idh J, Mulu A, Anagaw B, Belyhun Y et al (2012) Plasma IgE level and eosinophil count in smear positive tuberculosis patients with and without helminthic infections at Gondar University Hospital, Northwest Ethiopia. Eur J Exp Biol 2(6):2010-2014
16. Amare B, Belyhun Y, Moges B, Mulu A, Ota F, Tafess K et al (2012) Serum IgE levels of diarrheic patients in northwest Ethiopia with high prevalence of HIV and intestinal parasitoses. J AIDS Clin Res 3:136. doi: 10.4172/2155-6113.1000136
17. Kassu A, Fujino M, Nishizawa M, Mulu A, Trineh, M, Abate E et al (2007) Levels of serum HIV-1 RNA viral load in tuberculosis patients with or without intestinal parasites during treatment of tuberculosis in Gondar, Ethiopia. Ethiop J Heal Biomed Sci 1(1):5-13
18. Mulu A, Maier M, Liebert UG (2013) Deworming of intestinal helminths reduces HIV-1 subtype C viremia in chronically co-infected individuals. Int J Infect Dis 17(10):e897-e901. doi: 10.1016/j.ijid.2013.03.022
19. Wolday D, Mayaan S, Mariam ZG, Berhe N, Seboxa T, Britton S et al (2002) Treatment of intestinal worms is associated with decreased HIV plasma viral load. J Acquir Immune Defic Syndr 31:56-62
20. Lawn SD, Karanja DM, Mwinzia P, Andove J, Colley DG, Folks TM et al (2000) The effect of treatment of schistosomiasis on blood plasma HIV-1 RNA concentration in coinfected individuals. AIDS 14:2437-2443
21. Walson JL, Herrin BR, John-Stewart G (2009) Deworming helminth co-infected individuals for delaying HIV disease progression. Cochrane Database Syst Rev (3):CD006419. doi: 10.1002/14651858.CD006419.pub3
22. Alexander PE, De P (2009) HIV-1 and intestinal helminth review update: Updating a Cochrane Review and building the case for treatment and has the time come to test and treat? Parasite Immunology 31:283-286. doi: 10.1111/j.1365-3024.2009.01100.x
23. WHO (2005) Interim WHO clinical staging of HIV/AIDS and HIV/AIDS case definitions for surveillance African region, WHO/HIV/2005.02. WHO, Geneva. http://www.who.int/hiv/pub/guidelines/. Accessed 2 Sept 2013
24. Cheesbrough M (1998) District laboratory practice in Tropical countries, Tropical health technology. Part I. Cambridge University Press, Cambridge, pp 192-198
25. Mkhize-Kwitshana Z, Taylor M, Jooste P, Mabaso M, Walzl G (2011) The influence of different helminth infection phenotypes on immune responses against HIV in coinfected adults in South Africa. BMC Infect Dis 11:273
26. McSorley HJ, Hewitson PJ, Maizels MR (2013) Immunomodulation by helminth parasites: defining mechanisms and mediators. Int J Parasitol. doi: 10.1016/j.ijpara.2012.11.011
27. Sonaimuthu B, Baghyanathan V (2012) Study on the functional role of immunoglobulin E as surrogate marker for HIV/AIDS infection. Retrovirology 9(Suppl 2):P96. doi: 10.1186/1742-4690-9-S2-P96
28. Dugas N, Dereuddre-Bosquet N, Goujard C, Dormont D, Tardieu M, Delfraissy JF (2000) Role of nitric oxide in the promoting effect of HIV type 1 infection and of gp 120 envelop glycoprotein on interleukin 4-induced IgE production by normal human mononuclear cells. AIDS Res Hum Retroviruses 16:251-258
29. Haus M, Heese H, De V, Weinberg EG, Potter PC, Hall MJ et al (1988) The influence of ethnicity, an atopic family history and maternal ascariasis on cord blood serum IgE concentrations. J Allergy Clin Immunol 82:179-189
30. Abate E, Belayneh M, Gelaw A, Idh J, Getachew A, Alemu S et al (2012) The impact of asymptomatic helminth co-infection in patients with newly diagnosed tuberculosis in north-west Ethiopia. PLoS One 7(8):e42901. doi: 10.1371/journal.pone.0042901
31. Fehintola FA, Ademowo OG (2009) Efficacy of cotrimoxazole-chloroquine in the treatment of Schistosoma mansoni. Trans R Soc Trop Med Hyg 77:363-371
32. Messele T, Abdulkadir M, Fontanet AL, Petros B, Hamann D, Koot M et al (1999) Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clin Exp Immunol 115:443-450
33. Mulu A, Liebert UG, Maier M (2014) Virological efficacy and immunological recovery among Ethiopian HIV-1 infected adults and children. BMC Infect Dis 14(1):28. doi: 10.1186/1471-2334-14-28
34. Bundy DAP, Walson JL, Watkins KL (2013) Worms, wisdom, and wealth: why deworming can make economic sense. Trends Parasitol 29(3):142-148