Deworming of intestinal helminths reduces HIV-1 subtype C viremia in chronically co-infected individuals

International Journal of Infectious Diseases

Volumn 17, Issue 10, 2013, Pages

  Mulu, Andargachew ^a,b   Maier, Melanie ^a   Liebert, Uwe Gerd ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF GONDAR   (Ethiopia)

Author keywords

CD4+ T cell; CD8+ T cell; Deworming; HIV 1 subtype C; Viremia

Indexed keywords

ALBENDAZOLE; PRAZIQUANTEL; VIRUS RNA;

ADULT; ARTICLE; BLOOD LEVEL; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; ETHIOPIA; FEMALE; FOLLOW UP; HELMINTH; HELMINTHIASIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INTESTINE PARASITE; LONGITUDINAL STUDY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PARASITE LOAD; PERIPHERAL LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT DURATION; VIREMIA; VIRUS LOAD; WORM EXPULSION;

CD4(+) T CELL; CD8(+) T CELL; DEWORMING; HIV-1 SUBTYPE C; VIREMIA;

ADULT; ANIMALS; ANTHELMINTICS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; COINFECTION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INTESTINES; MALE; NEMATODE INFECTIONS; PROSPECTIVE STUDIES; RNA, VIRAL; SCHISTOSOMIASIS MANSONI; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84883812049     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2013.03.022     Document Type: Article

References (31)

1. World Health Organization HIV/AIDS Program Global HIV epidemic updates 2011 2011, WHO, Geneva.
2. Brooker S. Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers-a review. Int J Parasitol 2010, 40:1137-1144.
3. Bentwich Z., Kalinkovich A., Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today 1995, 16:187-191.
4. Bentwich Z., Weisman Z., Moroz C., Bar-Yehuda S., Kalinkovich A. Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infections?. Clin Exp Immunol 1996, 103:239-243.
5. Kalinkovich A., Weisman Z., Bentwich Z. Chemokines and chemokine receptors: role in HIV infection. Immunol Lett 1999, 68:281-287.
6. Bentwich Z., Maartens G., Torten D., Lal A., Lal R. Concurrent infections and HIV pathogenesis. AIDS 2000, 14:2071-2081.
7. Bentwich Z., Kalinkovich A., Weisman Z., Borkow G., Beyers N., Beyers A.D. Can eradication of helminthic infections change the face of AIDS and tuberculosis?. Immunol Today 1999, 20:485-487.
8. Wolday D., Mayaan S., Mariam Z.G., Berhe N., Seboxa T., Britton S., et al. Treatment of intestinal worms is associated with decreased HIV plasma viral load. J Acquir Immune Defic Syndr 2002, 31:56-62.
9. Walson J.L., Otieno P.A., Mbuchi M., Richardson B.A., Lohman-Payne B., Macharia S.W., et al. Albendazole treatment among adults with HIV-1 and helminth co-infection: a randomized double blind placebo trial. AIDS 2008, 22:1601-1609.
10. Elliott A.M., Mawa P.A., Joseph S., Namujju P.B., Kizza M., Nakiyingi J.S., et al. Associations between helminth infection and CD4+ T cell count, viral load and cytokine responses in HIV-1-infected Ugandan adults. Trans R Soc Trop Med Hyg 2003, 97:103-108.
11. Hosseinipour M.C., Napravnik S., Joaki G., Gama S., Mbeye N., Banda B., et al. HIV and parasitic infection and the effect of treatment among adult outpatients in Malawi. J Infect Dis 2007, 195:1278-1282.
12. Modjarrad K., Zulu I., Redden D.T., Njobvu L., Lane H.C., Bentwich Z., Vermund S.H. Treatment of intestinal helminths does not reduce plasma concentrations of HIV-1 RNA in coinfected Zambian adults. J Infect Dis 2005, 192:1277-1283.
13. Interim WHO clinical staging of HIV/AIDS and HIV/AIDS case definitions for surveillance African region. WHO/HIV/2005.02. Geneva: WHO; 2005. Available at: (accessed September 2, 2012). http://www.who.int/hiv/pub/guidelines/.
14. Cheesbrough M. District laboratory practice in tropical countries 1998, 192-198. Tropical Health Technology, Norfolk, UK.
15. Kassu A., Fujino M., Nishizawa M., Mengistu G., Diro E., Ayele B., et al. Levels of serum HIV-1 RNA viral load in tuberculosis patients with or without intestinal parasites during treatment of tuberculosis in Gondar. Ethiopia. Ethiop J Heal & Biomed Sci 2008, 1:1-7.
16. Walson J.L., Herrin B.R., John-Stewart G. Deworming helminth co-infected individuals for delaying HIV disease progression. Cochrane Database Syst Rev 2009, (3):CD006419.
17. Quinn T.C., Wawer M.J., Sewankambo N., Serwadda D., Li C., Wabwire-Mangen F., et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000, 342:921-929.
18. Mellors J.W., Munoz A., Giorgi J.V., Margolick J.B., Tassoni C.J., Gupta P., et al. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997, 126:946-954.
19. Morgan D., Whitworth J. The natural history of HIV-1 infection in Africa. Nat Med 2001, 7:143-145.
20. Bentwich Z., Weisman Z., Grossman Z., Galai N., Kalinkovich A. Pathogenesis of AIDS in Africa-lessons from the Ethiopian immigrants in Israel. Immunologist 1997, 5:211-226.
21. Kalinkovich A., Weisman Z., Greenberg Z., Nahmias J., Eitan S., Stein M., Bentwich Z. Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection. Clin Exp Immunol 1998, 114:414-421.
22. Brown M., Kizza M., Watera C., Quigley M.A., Rowland S., Hughes P., et al. Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. J Infect Dis 2004, 190:1869-1879.
23. Messele T., Abdulkadir M., Fontanet A.L., Petros B., Hamann D., Koot M., et al. Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clin Exp Immunol 1999, 115:443-450.
24. Lawn S.D., Karanja D.M., Mwinzia P., Andove J., Colley D.G., Folks T.M., et al. The effect of treatment of schistosomiasis on blood plasma HIV-1 RNA concentration in coinfected individuals. AIDS 2000, 14:2437-2443.
25. Kassu A., Tsegaye A., Wolday D., Petros B., Aklilu M., Sanders E.J., et al. Role of incidental and/or cured intestinal parasitic infections on profile of CD4+ and CD8+ T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians. Clin Exp Immunol 2003, 132:113-119.
26. Tsegaye A., Messele T., Tilahun T., Hailu E., Sahlu T., Doorly R., et al. Immunohematological reference ranges for adult Ethiopians. Clin Diagn Lab Immunol 1999, 6:410-414.
27. Tadesse A., Kassu A. Intestinal parasite isolates in AIDS patients with chronic diarrhea in Gondar Teaching Hospital. Northwest Ethiopia. Ethiop Med J 2005, 43:93-96.
28. Dyer J.R., Eron J.J., Hoffman I.F., Kazembe P., Vernazza P.L., Nkata E., et al. Association of CD4 cell depletion and elevated blood and seminal plasma human immunodeficiency virus type 1 (HIV-1) RNA concentrations with genital ulcer disease in HIV-1-infected men in Malawi. J Infect Dis 1998, 177:224-227.
29. Hoffman I.F., Jere C.S., Taylor T.E., Munthali P., Dyer J.R., Wirima J.J., et al. The effect of P. falciparum malaria on HIV-1 RNA blood plasma concentration. AIDS 1999, 13:487-494.
30. Anzala A.O., Simonsen J.N., Kimani J., Ball T.B., Nagelkerke N.J., Rutherford J., et al. Acute sexually transmitted infections increase HIV-1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts. J Infect Dis 2000, 182:459-466.
31. Bergquist R., Johansen M.V., Utzinger J. Diagnostic dilemmas in helminthology: what tools to use and when?. Trends Parasitol 2009, 25:151-156.