메뉴 건너뛰기




Volumn 25, Issue 8, 2015, Pages 873-884

Novel diagnostic tools and solutions for multiple sclerosis treatment: A patent review (2009-2014)

Author keywords

Autoimmunity; Circulatory abnormality; Inflammation; Oligodendropathy; Redox processes

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOPOETIN 2 INHIBITOR; BETA INTERFERON; BIOLOGICAL MARKER; CYCLOSPORIN A; DACLIZUMAB; DAPTOMYCIN; GELSOLIN; IDEBENONE; MURAMYL DIPEPTIDE; MYELIN BASIC PROTEIN; OXADIAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TERIFLUNOMIDE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

EID: 84937197241     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2015.1043267     Document Type: Review
Times cited : (11)

References (93)
  • 3
    • 0000361150 scopus 로고
    • Histology of "sclerose en plaque" (in French)
    • Charcot JM. Histology of "sclerose en plaque" (in French). Gazette Hosp (Paris) 1868;41:554-66
    • (1868) Gazette Hosp (Paris) , vol.41 , pp. 554-566
    • Charcot, J.M.1
  • 4
  • 5
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis I. Clinical results of a multicenter, randomized, double-blind, placebocontrolled trial
    • The IFNB Multiple Sclerosis Study Group
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis I. Clinical results of a multicenter, randomized, double-blind, placebocontrolled trial. Neurology 1993;43(4):655-61
    • (1993) Neurology , vol.43 , Issue.4 , pp. 655-661
  • 6
    • 0023248694 scopus 로고
    • A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis
    • Bornstein MB, Miller A, Slagle S, et al. A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis. N Eng J Med 1987;317:408-14
    • (1987) N Eng J Med , vol.317 , pp. 408-414
    • Bornstein, M.B.1    Miller, A.2    Slagle, S.3
  • 8
    • 0030987548 scopus 로고    scopus 로고
    • Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis
    • Aharoni R, Teitelbaum D, Sela M, et al. Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis. Proc Nat Acad Sci USA 1997;94(20):10821-6
    • (1997) Proc Nat Acad Sci USA , vol.94 , Issue.20 , pp. 10821-10826
    • Aharoni, R.1    Teitelbaum, D.2    Sela, M.3
  • 9
    • 54049087015 scopus 로고    scopus 로고
    • Assessment: The use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review). Report of the therapeutics and technology assessment subcommittee of the American academy of neurology
    • Goodin DS, Cohen BA, O'Connor P, et al. Assessment: The use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review). Report of the therapeutics and technology assessment subcommittee of the American academy of neurology. Neurology 2008;71(10):766-73
    • (2008) Neurology , vol.71 , Issue.10 , pp. 766-773
    • Goodin, D.S.1    Cohen, B.A.2    O'connor, P.3
  • 10
    • 0345305703 scopus 로고    scopus 로고
    • The use of mitoxantrone (Novantrone) for the treatment of multiple sclerosis
    • Goodin DS, Arnason BG, Coyle PK, et al. The use of mitoxantrone (Novantrone) for the treatment of multiple sclerosis. Neurology 2003;61(10):1332-8
    • (2003) Neurology , vol.61 , Issue.10 , pp. 1332-1338
    • Goodin, D.S.1    Arnason, B.G.2    Coyle, P.K.3
  • 11
    • 0034676548 scopus 로고    scopus 로고
    • Relapses and progression of disability in multiple sclerosis
    • Confavreux C, Vukusic S, Moreau T, et al. Relapses and progression of disability in multiple sclerosis. N Engl J Med 2000;343:1430-8
    • (2000) N Engl J Med , vol.343 , pp. 1430-1438
    • Confavreux, C.1    Vukusic, S.2    Moreau, T.3
  • 12
    • 0032881051 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: A geographically based study 7. Progressive-relapsing and relapsing-progressive multiple sclerosis: A re-evaluation
    • Kremenchutzky M, Cottrell D, Rice G, et al. The natural history of multiple sclerosis: A geographically based study 7. Progressive-relapsing and relapsing-progressive multiple sclerosis: A re-evaluation. Brain 1999;122(10):1941-50
    • (1999) Brain , vol.122 , Issue.10 , pp. 1941-1950
    • Kremenchutzky, M.1    Cottrell, D.2    Rice, G.3
  • 13
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis
    • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis. Neurology 1996;46:907-11
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 14
    • 0037441370 scopus 로고    scopus 로고
    • Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis
    • Vukusic S, Confavreux C. Prognostic factors for progression of disability in the secondary progressive phase of multiple sclerosis. J Neurol Sci 2003;206(2):135-7
    • (2003) J Neurol Sci , vol.206 , Issue.2 , pp. 135-137
    • Vukusic, S.1    Confavreux, C.2
  • 15
    • 22444447949 scopus 로고    scopus 로고
    • Primary progressive multiple sclerosis
    • Leary SM, Thompson AJ. Primary progressive multiple sclerosis. CNS Drugs 2005;19(5):369-76
    • (2005) CNS Drugs , vol.19 , Issue.5 , pp. 369-376
    • Leary, S.M.1    Thompson, A.J.2
  • 16
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
    • McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50(1):121-7
    • (2001) Ann Neurol , vol.50 , Issue.1 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3
  • 17
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2010 revision to the McDonald criteria
    • Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revision to the McDonald criteria. Ann Neurol 2011;69(2):292-302
    • (2011) Ann Neurol , vol.69 , Issue.2 , pp. 292-302
    • Polman, C.H.1    Reingold, S.C.2    Banwell, B.3
  • 18
    • 28544436950 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald criteria"
    • Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald criteria". Ann Neurol 2005;58(2):840-6
    • (2005) Ann Neurol , vol.58 , Issue.2 , pp. 840-846
    • Polman, C.H.1    Reingold, S.C.2    Edan, G.3
  • 19
    • 84857052288 scopus 로고    scopus 로고
    • Current concepts in multiple sclerosis: Autoimmunity versus oligodendrogliopathy
    • Nakahara J, Maeda M, Aiso S, et al. Current concepts in multiple sclerosis: Autoimmunity versus oligodendrogliopathy. Clin Rev Allergy Immunol 2012;42:26-34
    • (2012) Clin Rev Allergy Immunol , vol.42 , pp. 26-34
    • Nakahara, J.1    Maeda, M.2    Aiso, S.3
  • 20
    • 84885072257 scopus 로고    scopus 로고
    • Multiple sclerosis: Molecular mechanisms and therapeutic opportunities
    • Miljkovic D, Spasojevic I. Multiple sclerosis: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 2013;19(18):2286-334
    • (2013) Antioxid Redox Signal , vol.19 , Issue.18 , pp. 2286-2334
    • Miljkovic, D.1    Spasojevic, I.2
  • 21
    • 69149108015 scopus 로고    scopus 로고
    • Molecular and immunogenic features of myelin lipids: Incitants or modulators of multiple sclerosis
    • Podbielska M, Hogan EL. Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis? Mult Scler 2009;15:1011-29
    • (2009) Mult Scler , vol.15 , pp. 1011-1029
    • Podbielska, M.1    Hogan, E.L.2
  • 22
    • 0029075492 scopus 로고
    • Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis
    • Balashov KE, Khoury SJ, Hafler DA, et al. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest 1995;95(6):2711-19
    • (1995) J Clin Invest , vol.95 , Issue.6 , pp. 2711-2719
    • Balashov, K.E.1    Khoury, S.J.2    Hafler, D.A.3
  • 23
    • 27944499757 scopus 로고    scopus 로고
    • Reduced suppressive effect of CD4 +CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
    • Haas J, Hug A, Viehover A, et al. Reduced suppressive effect of CD4 +CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 2005;35(11):3343-52
    • (2005) Eur J Immunol , vol.35 , Issue.11 , pp. 3343-3352
    • Haas, J.1    Hug, A.2    Viehover, A.3
  • 24
    • 0035283409 scopus 로고    scopus 로고
    • Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: Imbalance of Th1/Th2-associated chemokine signaling
    • Misu T, Onodera H, Fujihara K, et al. Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling. J Neuroimmunol 2001;114(1-2):207-12
    • (2001) J Neuroimmunol , vol.114 , Issue.1-2 , pp. 207-212
    • Misu, T.1    Onodera, H.2    Fujihara, K.3
  • 25
    • 0036845819 scopus 로고    scopus 로고
    • Glatiramer acetate-specific T-helper 1-and 2-type cell lines produce BDNF: Implications for multiple sclerosis therapy
    • Ziemssen T, Kümpfel T, Klinkert WE, et al. Glatiramer acetate-specific T-helper 1-and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain 2002;125(11):2381-91
    • (2002) Brain , vol.125 , Issue.11 , pp. 2381-2391
    • Ziemssen, T.1    Kümpfel, T.2    Klinkert, W.E.3
  • 26
    • 34547196914 scopus 로고    scopus 로고
    • Peptides as autoimmune diseases antigenic probes
    • Alcaro MC, Lolli F, Migliorini P, et al. Peptides as autoimmune diseases antigenic probes. Chemistry Today 2007;25(3):14-16
    • (2007) Chemistry Today , vol.25 , Issue.3 , pp. 14-16
    • Alcaro, M.C.1    Lolli, F.2    Migliorini, P.3
  • 27
    • 84871006600 scopus 로고    scopus 로고
    • Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis
    • Pandey S, Alcaro MC, Scrima M, et al. Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. J Med Chem 2012;55(23):10437-47
    • (2012) J Med Chem , vol.55 , Issue.23 , pp. 10437-10447
    • Pandey, S.1    Alcaro, M.C.2    Scrima, M.3
  • 28
    • 84874078046 scopus 로고    scopus 로고
    • Alpha actinin is specifically recognized by multiple sclerosis autoantibodies isolated using an N-glucosylated peptide epitope
    • Pandey S, Dioni I, Lambardi D, et al. Alpha actinin is specifically recognized by multiple sclerosis autoantibodies isolated using an N-glucosylated peptide epitope. Mol Cell Proteomics 2013;12:277-82
    • (2013) Mol Cell Proteomics , vol.12 , pp. 277-282
    • Pandey, S.1    Dioni, I.2    Lambardi, D.3
  • 29
    • 84893560857 scopus 로고    scopus 로고
    • Immunoglobulin G subclass profile of anticitrullinated peptide antibodies specific for Epstein Barr Virus-derived and histone-derived citrullinated peptides
    • Panza F, Pratesi F, Valoriani D, et al. Immunoglobulin G subclass profile of anticitrullinated peptide antibodies specific for Epstein Barr Virus-derived and histone-derived citrullinated peptides. J Rheumatol 2014;41(2):407-8
    • (2014) J Rheumatol , vol.41 , Issue.2 , pp. 407-408
    • Panza, F.1    Pratesi, F.2    Valoriani, D.3
  • 30
    • 70449650528 scopus 로고    scopus 로고
    • The use of posttranslationally modified peptides for detection of biomarkers of immunemediated diseases
    • Papini AM. The use of posttranslationally modified peptides for detection of biomarkers of immunemediated diseases. J Peptide Sci 2009;15:621-8
    • (2009) J Peptide Sci , vol.15 , pp. 621-628
    • Papini, A.M.1
  • 31
    • 84902275702 scopus 로고    scopus 로고
    • Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps
    • Pratesi F, Dioni I, Tommasi C, et al. Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps. Ann Rheumatic Dis 2013;73:1414-22
    • (2013) Ann Rheumatic Dis , vol.73 , pp. 1414-1422
    • Pratesi, F.1    Dioni, I.2    Tommasi, C.3
  • 32
    • 0035811457 scopus 로고    scopus 로고
    • Conformational analysis of a glycosylated human myelin oligodendrocyte glycoprotein peptide epitope able to detect antibody response in multiple sclerosis
    • Carotenuto A, D'Ursi AM, Nardi E, et al. Conformational analysis of a glycosylated human myelin oligodendrocyte glycoprotein peptide epitope able to detect antibody response in multiple sclerosis. J Med Chem 2001;44:2378-81
    • (2001) J Med Chem , vol.44 , pp. 2378-2381
    • Carotenuto, A.1    D'ursi, A.M.2    Nardi, E.3
  • 33
    • 24144443537 scopus 로고    scopus 로고
    • The glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosis
    • Lolli F, Mazzanti B, Pazzagli M, et al. The glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosis. J Neuroimmunol 2005;167:131-7
    • (2005) J Neuroimmunol , vol.167 , pp. 131-137
    • Lolli, F.1    Mazzanti, B.2    Pazzagli, M.3
  • 34
    • 22544448364 scopus 로고    scopus 로고
    • An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis
    • Lolli F, Mulinacci B, Carotenuto A, et al. An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis. Proc Nat Acad Sci USA 2005;102(29):10273-8
    • (2005) Proc Nat Acad Sci USA , vol.102 , Issue.29 , pp. 10273-10278
    • Lolli, F.1    Mulinacci, B.2    Carotenuto, A.3
  • 35
    • 84867985009 scopus 로고    scopus 로고
    • Citrullination under physiological and pathological conditions
    • Baka Z, Gyorgy B, Geher P, et al. Citrullination under physiological and pathological conditions. Joint Bone Spine 2012;79:431-6
    • (2012) Joint Bone Spine , vol.79 , pp. 431-436
    • Baka, Z.1    Gyorgy, B.2    Geher, P.3
  • 36
    • 0035796784 scopus 로고    scopus 로고
    • IgG reactivity against citrullinated myelin basic protein in multiple sclerosis
    • de Seze J, Duducquoi S, Lefranc D, et al. IgG reactivity against citrullinated myelin basic protein in multiple sclerosis. J Neuroimmunol 2001;117(1-2):149-55
    • (2001) J Neuroimmunol , vol.117 , Issue.1-2 , pp. 149-155
    • De Seze, J.1    Duducquoi, S.2    Lefranc, D.3
  • 37
    • 0142234077 scopus 로고    scopus 로고
    • Multiple Sclerosis: An important role for post-translational modifications of myelin basic protein in pathogenesis
    • Kim JK, Mastronardi FG, Wood DD, et al. Multiple Sclerosis: An important role for post-translational modifications of myelin basic protein in pathogenesis. Mol Cell Proteomics 2003;2:453-62
    • (2003) Mol Cell Proteomics , vol.2 , pp. 453-462
    • Kim, J.K.1    Mastronardi, F.G.2    Wood, D.D.3
  • 38
    • 33846914679 scopus 로고    scopus 로고
    • The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis
    • Moscarello M, Mastronardi FG, Wood DD. The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis. Neurochem Res 2007;32(2):251-6
    • (2007) Neurochem Res , vol.32 , Issue.2 , pp. 251-256
    • Moscarello, M.1    Mastronardi, F.G.2    Wood, D.D.3
  • 39
    • 0033845902 scopus 로고    scopus 로고
    • Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients
    • Tranquill LR, Cao L, Ling NC, et al. Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients. Mult Scler 2000;6(4):220-5
    • (2000) Mult Scler , vol.6 , Issue.4 , pp. 220-225
    • Tranquill, L.R.1    Cao, L.2    Ling, N.C.3
  • 40
    • 36448997799 scopus 로고    scopus 로고
    • Intracranial venous haemodynamics in multiple sclerosis
    • Zamboni P, Menegatti E, Bartolomei I, et al. Intracranial venous haemodynamics in multiple sclerosis. Cur Neurov Res 2007;4:252-8
    • (2007) Cur Neurov Res , vol.4 , pp. 252-258
    • Zamboni, P.1    Menegatti, E.2    Bartolomei, I.3
  • 41
    • 84962103135 scopus 로고    scopus 로고
    • System for diagnosing multiple sclerosis
    • Zamboni P. System for diagnosing multiple sclerosis. WO2009107152; 2008
    • WO2009107152 , vol.2008
    • Zamboni, P.1
  • 42
    • 84881260526 scopus 로고    scopus 로고
    • Chronic cerebrospinal venous insufficiency:case-control neurosonography results
    • Barreto AD, Brod SA, Bui TT, et al. Chronic cerebrospinal venous insufficiency: case-control neurosonography results. Ann Neurol 2013;73(6):721-8
    • (2013) Ann Neurol , vol.73 , Issue.6 , pp. 721-728
    • Barreto, A.D.1    Brod, S.A.2    Bui, T.T.3
  • 43
    • 84883739781 scopus 로고    scopus 로고
    • Concomitant analysis of arterial, venous, and CSF flows using phasecontrast MRI: A quantitative comparison between MS patients and healthy controls
    • ElSankari S, Baledent O, Pesch VV, et al. Concomitant analysis of arterial, venous, and CSF flows using phasecontrast MRI: A quantitative comparison between MS patients and healthy controls. J Cereb Blood Flow Metab 2013;33:1314-21
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1314-1321
    • Elsankari, S.1    Baledent, O.2    Pesch, V.V.3
  • 44
    • 84962068718 scopus 로고    scopus 로고
    • Diagnostic and therapeutic methods, devices, and systems for multiple sclerosis, deep vein thrombosis, and pulmonary embolism patientsand therapeutic methods, devices, and systems for multiple sclerosis, deep vein thrombosis, and pulmonary embolism patients
    • Brown JE, Margolis MP, Gaddis ML. Diagnostic and therapeutic methods, devices, and systems for multiple sclerosis, deep vein thrombosis, and pulmonary embolism patients. WO092444; 2012
    • (2012) WO092444
    • Brown, J.E.1    Margolis, M.P.2    Gaddis, M.L.3
  • 45
    • 0018667209 scopus 로고
    • Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein
    • Yin HL, Stossel TP. Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature 1979;281:583-6
    • (1979) Nature , vol.281 , pp. 583-586
    • Yin, H.L.1    Stossel, T.P.2
  • 46
    • 65549117004 scopus 로고    scopus 로고
    • Plasma gelsolin: Function, prognostic value, and potential therapeutic use
    • Bucki R, Levental I, Kulakowska A, et al. Plasma gelsolin: function, prognostic value, and potential therapeutic use. Curr Protein Pept Sci 2008;9(6):541-51
    • (2008) Curr Protein Pept Sci , vol.9 , Issue.6 , pp. 541-551
    • Bucki, R.1    Levental, I.2    Kulakowska, A.3
  • 47
    • 33646464973 scopus 로고    scopus 로고
    • Lysophosphatidic acid and lipopolysaccharide bind to the PIP2-binding domain of gelsolin
    • Mintzer E, Sargsyan H, Bittman R. Lysophosphatidic acid and lipopolysaccharide bind to the PIP2-binding domain of gelsolin. Biochim Biophys Acta 2006;1758(1):85-9
    • (2006) Biochim Biophys Acta , vol.1758 , Issue.1 , pp. 85-89
    • Mintzer, E.1    Sargsyan, H.2    Bittman, R.3
  • 48
    • 84962126528 scopus 로고    scopus 로고
    • Use of gelsolin to treat multiple sclerosis and to diagnose neurological disease
    • Stossel TP, Lee P-S, Dittel B, et al. Use of gelsolin to treat multiple sclerosis and to diagnose neurological disease. US8440662; 2013
    • (2013) US8440662
    • Stossel, T.P.1    Lee, P.-S.2    Dittel, B.3
  • 49
    • 58149332839 scopus 로고    scopus 로고
    • Transketolase and 2, 3-cyclic-nucleotide 3-phosphodiesterase type i isoforms are specifically recognized by IgG autoantibodies in Multiple Sclerosis patients
    • Lovato L, Cianti R, Gini B, et al. Transketolase and 2, 3-cyclic-nucleotide 3-phosphodiesterase type I isoforms are specifically recognized by IgG autoantibodies in Multiple Sclerosis patients. Mol Cell Proteomics 2008;7:2337-49
    • (2008) Mol Cell Proteomics , vol.7 , pp. 2337-2349
    • Lovato, L.1    Cianti, R.2    Gini, B.3
  • 50
    • 84962065878 scopus 로고    scopus 로고
    • Gene expression profiling for identification, monitoring and treatment of multiple sclerosis
    • Bevilacqua M, Tryon V, Bankaitis-Davis D, et al. Gene expression profiling for identification, monitoring and treatment of multiple sclerosis. WO2008008487; 2006
    • (2006) WO2008008487
    • Bevilacqua, M.1    Tryon, V.2    Bankaitis-Davis, D.3
  • 52
    • 84962055541 scopus 로고    scopus 로고
    • Mononucleotide polymorphisms of the human chromosome 4 in the inositol polyphosphate 4-phosphatase type II Gene (INPP4b Gene) for diagnosing or prediagnosing multiple sclerosis
    • Ibrahim S. Mononucleotide polymorphisms of the human chromosome 4 in the inositol polyphosphate 4-phosphatase type II gene (INPP4b gene) for diagnosing or prediagnosing multiple sclerosis. WO2011101466; 2010
    • (2010) WO2011101466
    • Ibrahim, S.1
  • 53
    • 84962114924 scopus 로고    scopus 로고
    • VH4 codon signature for multiple sclerosis
    • Monson N. VH4 codon signature for multiple sclerosis. WO2010011894; 2008
    • (2008) WO2010011894
    • Monson, N.1
  • 54
    • 34249875751 scopus 로고    scopus 로고
    • Mature B cells class switched to IgD are autoreactive in healthy individuals
    • Koelsch K, Zheng NY, Zhang Q, et al. Mature B cells class switched to IgD are autoreactive in healthy individuals. J Clin Invest 2007;117(6):1558-65
    • (2007) J Clin Invest , vol.117 , Issue.6 , pp. 1558-1565
    • Koelsch, K.1    Zheng, N.Y.2    Zhang, Q.3
  • 55
    • 84962078132 scopus 로고    scopus 로고
    • Methods for treating multiple sclerosis using antisense oligonucleotides
    • Klinger E, Tessler S, Hussein H, et al. Methods for treating multiple sclerosis using antisense oligonucleotides. US8759314; 2014
    • (2014) US8759314
    • Klinger, E.1    Tessler, S.2    Hussein, H.3
  • 56
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis:Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000;6:1167-75
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3
  • 57
    • 84962126323 scopus 로고    scopus 로고
    • Compositions comprising myelin basic protein peptides and medical uses thereof
    • Wraith D, Streeter H. Compositions comprising myelin basic protein peptides and medical uses thereof. EP2211892; 2011
    • EP2211892 , vol.2011
    • Wraith, D.1    Streeter, H.2
  • 58
    • 84962083424 scopus 로고    scopus 로고
    • FC gamma receptor for the treatment of b cell mediated multiple sclerosis
    • Buckel P, Jacob U. FC gamma receptor for the treatment of B cell mediated multiple sclerosis. WO2010026168; 2008
    • (2008) WO2010026168
    • Buckel, P.1    Jacob, U.2
  • 59
    • 10344250945 scopus 로고    scopus 로고
    • A serum autoantibody marker of neuromyelitis optica:distinction from multiple sclerosis
    • Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004;364(9451):2106-12
    • (2004) Lancet , vol.364 , Issue.9451 , pp. 2106-2112
    • Lennon, V.A.1    Wingerchuk, D.M.2    Kryzer, T.J.3
  • 60
    • 84962049952 scopus 로고    scopus 로고
    • Methods for monitoring the efficacy of anti-il-2r antibodies in multiple sclerosis patients
    • Sheridan III JP. Methods for monitoring the efficacy of anti-IL-2R antibodies in multiple sclerosis patients. EP2425250; 2014
    • EP2425250 , vol.2014
    • Sheridan, J.P.1
  • 61
    • 77949301468 scopus 로고    scopus 로고
    • Daclizumab in active relapsing multiple sclerosis (CHOICE study:A Phase II, randomised, double-blind, placebo-controlled, add-on trial with interferon beta
    • Wynn D, Kaufman M, Montalban X, et al. Daclizumab in active relapsing multiple sclerosis (CHOICE study): A Phase II, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. Lancet Neurol 2010;9(4):381-90
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 381-390
    • Wynn, D.1    Kaufman, M.2    Montalban, X.3
  • 62
  • 63
    • 2942665465 scopus 로고    scopus 로고
    • The safety and efficacy of daptomycin for the treatment of complicated skin and skinstructure infections
    • Arbeit RD, Maki D, Tally FP, et al. The safety and efficacy of daptomycin for the treatment of complicated skin and skinstructure infections. Clin Infect Dis 2004;38(12):1673-81
    • (2004) Clin Infect Dis , vol.38 , Issue.12 , pp. 1673-1681
    • Arbeit, R.D.1    Maki, D.2    Tally, F.P.3
  • 65
    • 84962103113 scopus 로고    scopus 로고
    • Daptomycin for multiple sclerosis
    • Guarnaccia JB. Daptomycin for multiple sclerosis. WO2011043788; 2009
    • (2009) WO2011043788
    • Guarnaccia, J.B.1
  • 66
    • 84962046456 scopus 로고    scopus 로고
    • Composition and methods for treatment of multiple sclerosis
    • Gelder FB, Webster GA. Composition and methods for treatment of multiple sclerosis. WO2010147484; 2009
    • (2009) WO2010147484
    • Gelder, F.B.1    Webster, G.A.2
  • 67
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's Disease
    • Inohara N, Ogura Y, Fontalba A, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's Disease. J Biol Chem 2003;278(8):5509-12
    • (2003) J Biol Chem , vol.278 , Issue.8 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 68
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3/ cryopyrin inflammasome
    • Martinon F, Agostini L, Meylan E, et al. Identification of bacterial muramyl dipeptide as activator of the NALP3/ cryopyrin inflammasome. Cur Biol 2004;14(21):1929-34
    • (2004) Cur Biol , vol.14 , Issue.21 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3
  • 69
    • 84962058427 scopus 로고    scopus 로고
    • Quinone derivatives for treating or preventing diseases associated with iron overload
    • Rustin P, Rotig A. Quinone derivatives for treating or preventing diseases associated with iron overload. EP0402703; 1998
    • (1998) EP0402703
    • Rustin, P.1    Rotig, A.2
  • 70
    • 0025203601 scopus 로고
    • Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone:A review
    • Zs-Nagy I. Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: A review. Arch Gerontol Geriatr 1990;11(3):177-86
    • (1990) Arch Gerontol Geriatr , vol.11 , Issue.3 , pp. 177-186
    • Zs-Nagy, I.1
  • 71
    • 84962065859 scopus 로고    scopus 로고
    • Quinone derivative 2, 3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1, 4-benzoquinone for the treatment of primary progressive multiple sclerosis
    • Meier T, Bielekova B, McFarland HF. Quinone derivative 2, 3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1, 4-benzoquinone for the treatment of primary progressive multiple sclerosis. WO2010124713; 2009
    • (2009) WO2010124713
    • Meier, T.1    Bielekova, B.2    McFarland, H.F.3
  • 72
    • 84962114899 scopus 로고    scopus 로고
    • Composition and uses for treating multiple sclerosis
    • Lukashev ME, O'Neill G. Composition and uses for treating multiple sclerosis. WO2008097596; 2007
    • (2007) WO2008097596
    • Lukashev, M.E.1    O'neill, G.2
  • 73
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362(5):387-401
    • (2010) N Engl J Med , vol.362 , Issue.5 , pp. 387-401
    • Kappos, L.1    Radue, E.W.2    O'connor, P.3
  • 74
    • 84962084845 scopus 로고    scopus 로고
    • 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
    • Bombrun A, Schwarz M, Crosigniani S, et al. 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis. EP2183224; 2013
    • (2013) EP2183224
    • Bombrun, A.1    Schwarz, M.2    Crosigniani, S.3
  • 75
    • 84962097224 scopus 로고    scopus 로고
    • Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis
    • Muzerelle M, Quattropani A, Montagne C, et al. Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis. US8741923; 2014
    • (2014) US8741923
    • Muzerelle, M.1    Quattropani, A.2    Montagne, C.3
  • 77
    • 84962081304 scopus 로고    scopus 로고
    • Combination of interferonbeta and a cladribine regimen for treating multiple sclerosis
    • Brentzel HJ, Lopez-Bresnahan M, Ammoury N. Combination of interferonbeta and a cladribine regimen for treating multiple sclerosis. EP2026832; 2012
    • (2012) EP2026832
    • Brentzel, H.J.1    Lopez-Bresnahan, M.2    Ammoury, N.3
  • 78
    • 0031739385 scopus 로고    scopus 로고
    • Safety and tolerability of subcutaneous cladribine therapy in progressive multiple sclerosis
    • Selby R, Brandwein J, O'Connor P. Safety and tolerability of subcutaneous cladribine therapy in progressive multiple sclerosis. Can J Neurol Sci 1998;25(4):295-9
    • (1998) Can J Neurol Sci , vol.25 , Issue.4 , pp. 295-299
    • Selby, R.1    Brandwein, J.2    O'connor, P.3
  • 79
    • 0032908474 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting Multiple Sclerosis
    • Romine JS, Sipe JC, Koziol JA, et al. A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting Multiple Sclerosis. Proc Assoc Am Physicians 1999;111(1):35-44
    • (1999) Proc Assoc Am Physicians , vol.111 , Issue.1 , pp. 35-44
    • Romine, J.S.1    Sipe, J.C.2    Koziol, J.A.3
  • 80
    • 0034646216 scopus 로고    scopus 로고
    • Cladribine and progressive MS. Clinical and MRI outcomes of a multicenter controlled trial
    • Rice GPA, Filippi M, Comi G, et al. Cladribine and progressive MS. Clinical and MRI outcomes of a multicenter controlled trial. Neurology 2000;54(5):1145-55
    • (2000) Neurology , vol.54 , Issue.5 , pp. 1145-1155
    • Rice, G.P.A.1    Filippi, M.2    Comi, G.3
  • 81
    • 84962084765 scopus 로고    scopus 로고
    • Use of the combination of teriflunomide and interferon beta for treating multiple sclerosis
    • Bryrnes W, Douillet P, Frangin G. Use of the combination of teriflunomide and interferon beta for treating multiple sclerosis. WO2011005907; 2009
    • (2009) WO2011005907
    • Bryrnes, W.1    Douillet, P.2    Frangin, G.3
  • 82
    • 84962072499 scopus 로고    scopus 로고
    • Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
    • Wettstein J. Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis. US6794410; 2001
    • (2001) US6794410
    • Wettstein, J.1
  • 83
    • 84962108951 scopus 로고    scopus 로고
    • Cyclic undecapeptides and derivatives as multiple sclerosis therapies
    • Forte M, Bourdette D. Cyclic undecapeptides and derivatives as multiple sclerosis therapies. EP2195009; 2014
    • (2014) EP2195009
    • Forte, M.1    Bourdette, D.2
  • 84
    • 0036828793 scopus 로고    scopus 로고
    • Neutralising antibodies to interferon beta during the treatment of multiple sclerosis
    • Giovannoni G, Munschauer FE, Deisenhammer F. Neutralising antibodies to interferon beta during the treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry 2002;73:465-9
    • (2002) J Neurol Neurosurg Psychiatry , vol.73 , pp. 465-469
    • Giovannoni, G.1    Munschauer, F.E.2    Deisenhammer, F.3
  • 85
    • 84861022041 scopus 로고    scopus 로고
    • Risk of natalizumabassociated progressive multifocal leukoencephalopathy
    • Bloomgren G, Richman S, Hotermans C, et al. Risk of natalizumabassociated progressive multifocal leukoencephalopathy. N Engl J Med 2012;366:1870-80
    • (2012) N Engl J Med , vol.366 , pp. 1870-1880
    • Bloomgren, G.1    Richman, S.2    Hotermans, C.3
  • 86
    • 77949279537 scopus 로고    scopus 로고
    • Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: Lessons from 28 cases
    • Clifford DB, DeLuca A, Simpson DM, et al. Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol 2010;9(4):438-46
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 438-446
    • Clifford, D.B.1    Deluca, A.2    Simpson, D.M.3
  • 87
    • 64749109556 scopus 로고    scopus 로고
    • Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
    • Zamboni P, Galeotti R, Menegatti E, et al. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2009;80:392-9
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 392-399
    • Zamboni, P.1    Galeotti, R.2    Menegatti, E.3
  • 88
    • 33745576851 scopus 로고    scopus 로고
    • Contribution of peptides to multiple sclerosis research
    • Alcaro MC, Papini AM. Contribution of peptides to multiple sclerosis research. Biopolymers 2006;84:349-67
    • (2006) Biopolymers , vol.84 , pp. 349-367
    • Alcaro, M.C.1    Papini, A.M.2
  • 89
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of Multiple Sclerosis
    • Sospedra M, Martin R. Immunology of Multiple Sclerosis. Ann Rev Immunol 2005;23:683-747
    • (2005) Ann Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 90
    • 0032772860 scopus 로고    scopus 로고
    • Immunopathogenesis of multiple sclerosis: The role of T cells
    • Martino G, Hartung HP. Immunopathogenesis of multiple sclerosis: the role of T cells. Cur Opin Neurol 1999;12(3):309-21
    • (1999) Cur Opin Neurol , vol.12 , Issue.3 , pp. 309-321
    • Martino, G.1    Hartung, H.P.2
  • 91
    • 0035499377 scopus 로고    scopus 로고
    • Short-term evolution of autoreactive T cell repertoire in multiple sclerosis
    • Vergelli M, Mazzanti B, Traggiai E, et al. Short-term evolution of autoreactive T cell repertoire in multiple sclerosis. J Neurosci Res 2001;66(3):517-24
    • (2001) J Neurosci Res , vol.66 , Issue.3 , pp. 517-524
    • Vergelli, M.1    Mazzanti, B.2    Traggiai, E.3
  • 92
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • McFarland HF, Martin R. Multiple sclerosis: A complicated picture of autoimmunity. Nat Immunol 2007;8:913-19
    • (2007) Nat Immunol , vol.8 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 93
    • 0034981293 scopus 로고    scopus 로고
    • Multiple sclerosis: Recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment
    • Lucchinetti C, Brück W, Noseworthy J. Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment. Curr Opin Neurol 2001;14(3):259-69
    • (2001) Curr Opin Neurol , vol.14 , Issue.3 , pp. 259-269
    • Lucchinetti, C.1    Brück, W.2    Noseworthy, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.