Conformational analysis of a glycosylated human myelin oligodendrocyte glycoprotein peptide epitope able to detect antibody response in multiple sclerosis

Journal of Medicinal Chemistry

Volumn 44, Issue 14, 2001, Pages 2378-2381

  Carotenuto, A ^a   D'Ursi, A M ^a   Nardi, E ^b   Papini, A M ^b   Rovero, P ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; AUTOANTIBODY; EPITOPE; GLYCOPROTEIN; MYELIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ANTIBODY RESPONSE; ARTICLE; BINDING SITE; CONFORMATION; DEMYELINATION; GLYCOSYLATION; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; OLIGODENDROGLIA;

AMINO ACID SEQUENCE; ANTIGENS, SURFACE; AUTOANTIBODIES; AUTOANTIGENS; EPITOPES; GLYCOSYLATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; MYELIN-ASSOCIATED GLYCOPROTEIN; OLIGODENDROGLIA; PROTEIN CONFORMATION;

EID: 0035811457     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010811t     Document Type: Article

References (23)

1. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
2. Differential ultrastructural localization of myelin basic protein and myelin/oligodendroglia glycoprotein and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats
3. The structure and function of myelin oligodendrocyte glycoprotein
4. Antibodies to myelin oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls
5. Identification of autoantibodies associated with myelin damage in multiple sclerosis
6. Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily
7. A molecular model of myelin oligodendrocyte glycoprotein
8. Synthetic immunochemistry of glycohexapeptide analogues characteristic of oncofetalfibronectin. Solid-phase synthesis and antigenic activity
9. Glycosylation affects both the three-dimensional structure and antibody binding properties of the HIV-1IIIB GP120 peptide RP135
10. A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody response in multiple sclerosis and other neurological diseases
11. Viscosity as a conformational sieve: NOE of linear peptides in cryoprotective mixtures
12. Teflon-coated peptides hexafluoroacetone trihydrate as a structure stabilizer for peptides
13. The chemical shift index: A fast method for the assignment of protein secondary structure through NMR spectroscopy
14. Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix
15. Torsion angle dynamics for NMR structure calculation with the new program DYANA
16. Conformational switching by asparagine-linked glycosylation
17. Involvement of side functions in peptide structures: The asx turn. Occurrence and conformational aspects
18. Multiple quantum filters for elucidating NMR coupling network
19. Practical aspect of two-dimensional transverse NOE spectroscopy
20. Investigation of exchange processes by two-dimensional NMR spectroscopy
21. 1H spin-spin coupling constants in proteins
22. The program XEASY for computer-supported NMR spectral analysis of biological macromolecules
23. Derivation of force fields for molecular mechanics and dynamics from Ab initio energy surface