MiR-126 inhibits the invasion of gastric cancer cell in part by targeting Crk

European Review for Medical and Pharmacological Sciences

Volumn 18, Issue 14, 2014, Pages 2031-2037

  Li, X ^a   Wang, F ^a   Qi, Y ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Crk; Gastric cancer; Invasion; Mir 126

Indexed keywords

CRK LIKE PROTEIN; CRYSTAL VIOLET; MICRORNA 126; CRK PROTEIN, HUMAN; MICRORNA; MIRN126 MICRORNA, HUMAN; ONCOPROTEIN; SMALL INTERFERING RNA;

ADULT; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; TUMOR INVASION; WESTERN BLOTTING; BIOSYNTHESIS; DOWN REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-CRK; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STOMACH NEOPLASMS;

EID: 84937026915     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. COMPARE D, ROCCO A, NARDONE G. Risk factors in gastric cancer. Eur Rev Med Pharmacol Sci 2010; 14: 302-308.
2. PARKIN DM, BRAY F, FERLAY J, PISANI P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
3. MIHALJEVIC AL, FRIESS H, SCHUHMACHER C. Clinical trials in gastric cancer and the future. J Surg Oncol 2013; 107: 289-297.
4. BERARDI R, SCARTOZZI M, ROMAGNOLI E, ANTOGNOLI S, CASCINU S. Gastric cancer treatment: a systematic review. Oncol Rep 2004; 11: 911-916.
5. FARAZI TA, HOELL JI, MOROZOV P, TUSCHL T. MicroRNAs in human cancer. Adv Exp Med Biol 2013; 774: 1-20.
6. WANG Z, YAO H, LIN S, ZHU X, SHEN Z, LU G, POON WS, XIE D, LIN MC, KUNG HF. Transcriptional and epigenetic regulation of human microRNAs. Cancer Lett 2013; 331: 1-10.
7. LAGES E, IPAS H, GUTTIN A, NESR H, BERGER F, ISSARTEL JP. MicroRNAs: molecular features and role in cancer. Front Biosci 2012; 17: 2508-2540.
8. HUANG Y, SHEN XJ, ZOU Q, WANG SP, TANG SM, ZHANG GZ. Biological functions of microRNAs: a review. J Physiol Biochem 2011; 67: 129-139.
9. SATO F, TSUCHIYA S, MELTZER SJ, SHIMIZU K. MicroRNAs and epigenetics. FEBS J 2011; 278: 1598-1609.
10. ANINDO MI, YAQINUDDIN A. Insights into the potential use of microRNAs as biomarker in cancer. Int J Surg 2012; 10: 443-449.
11. TAVAZOIE SF, ALARCÓN C, OSKARSSON T, PADUA D, WANG Q, BOS PD, GERALD WL, MASSAGUÉ J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008; 451: 147-152.
12. MUSIYENKO A, BITKO V, BARIK S. Ectopic expression of miR-126, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. J Mol Med (Berl) 2008; 86: 313-322.
13. CRAWFORD M, BRAWNER E, BATTE K, YU L, HUNTER MG, OTTERSON GA, NUOVO G, MARSH CB, NANASINKAM SP. MicroRNA-126 inhibits invasion in nonsmall cell lung carcinoma cell lines. Biochem Biophys Res Commun 2008; 373: 607-612.
14. LIU S, GAO S, WANG XY, WANG DB. Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression. Arch Gynecol Obstet 2012; 285: 1065-1072.
15. YIN WZ, LI F, ZHANG L, REN XP, ZHANG N, WEN JF. Down-regulation of MicroRNA-205 promotes gastric cancer cell proliferation. Eur Rev Med Pharmacol Sci 2014; 18: 1027-1032.
16. XU Y, DENG Y, YAN X, ZHOU T. Targeting miR-375 in gastric cancer. Expert Opin Ther Targets 2011; 15: 961-972.
17. LI F, LIU J, LI S. MicorRNA 106b∼25 cluster and gastric cancer. Surg Oncol 2013; 22: e7-10.
18. SAITO Y, FRIEDMAN JM, CHIHARA Y, EGGER G, CHUANG JC, LIANG G. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun 2009; 379: 726-731.
19. WANG Y, WENG T, GOU D, CHEN Z, CHINTAGARI NR, LIU L. Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research. BMC Genomics 2007; 8: 29.
20. BASKERVILLE S, BARTEL DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 2005; 11: 241-247.
21. HARRIS TA, YAMAKUCHI M, FERLITO M, MENDELL JT, LOWENSTEIN CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA 2008; 105: 1516-1521.
22. LIU B, PENG XC, ZHENG XL, WANG J, QIN YW. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer 2009; 66: 169-175.
23. ZHU N, ZHANG D, XIE H, ZHOU Z, CHEN H, HU T, BAI Y, SHEN Y, YUAN W, JING Q, QIN Y. Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem 2011; 351: 157-164.
24. YU Q, LIU SL, WANG H, SHI G, YANG P, CHEN XL. miR-126 Suppresses the proliferation of cervical cancer cells and alters cell sensitivity to the chemotherapeutic drug bleomycin. Asian Pac J Cancer Prev 2013; 14: 6569-6572.
25. OTSUBO T, AKIYAMA Y, HASHIMOTO Y, SHIMADA S, GOTO K, YUASA Y. MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS One 2011; 6: e16617.
26. PAGER CT, WEHNER KA, FUCHS G, SARNOW P. MicroRNA-mediated gene silencing. Prog Mol Biol Transl Sci 2009; 90: 187-210.
27. TSUDA M, TANAKA S. Roles for crk in cancer metastasis and invasion. Genes Cancer 2012; 3: 334-340.
28. YAMADA S, YANAMOTO S, KAWASAKI G, ROKUTANDA S, YONEZAWA H, KAWAKITA A, NEMOTO TK. Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma. Cancer Lett 2011; 303: 84-91.
29. TAKINO T, NAKADA M, MIYAMORI H, YAMASHITA J, YAMADA KM, SATO H. CrkI adapter protein modulates cell migration and invasion in glioblastoma. Cancer Res 2003; 63: 2335-2337.
30. FATHERS KE, BELL ES, RAJADURAI CV, CORY S, ZHAO H, MOURSKAIA A, ZUO D, MADORE J, MONAST A, MESMASSON AM, GROSSET AA, GABOURY L, HALLET M, SIEGEL P, PARK M. Crk adaptor proteins act as key signaling integrators for breast tumorigenesis. Breast Cancer Res 2012; 14: R74.
31. DAI Y, QI L, ZHANG X, LI Y, CHEN M, ZU X. CrkI and p130(Cas) complex regulates the migration and invasion of prostate cancer cells. Cell Biochem Funct 2011; 29: 625-629.