Detection of leukemia-associated mutations in peripheral blood DNA of hematologically normal elderly individuals

Leukemia

Volumn 29, Issue 7, 2015, Pages 1600-1602

  Score, J ^a,b   Chase, A ^a,b   Forsberg, L A ^c   Feng, L ^a   Waghorn, K ^a,b   Jones, A V ^a,b   Rasi, C ^c   Linch, D C ^d   Dumanski, J P ^c   Gale, R E ^d   Cross, N C P ^a,b  

^a WESSEX REGIONAL GENETICS LABORATORY   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

BLOOD ANALYSIS; BLOOD CELL COUNT; CD4+ T LYMPHOCYTE; CELL FRACTIONATION; CHROMOSOME 4; CHROMOSOME 4Q; CHROMOSOME DELETION; CHROMOSOME DUPLICATION; CHRONIC LYMPHATIC LEUKEMIA; EXON; GENE MUTATION; GENETIC ANALYSIS; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL; HETEROZYGOSITY LOSS; HUMAN; LETTER; LEUKEMIA ASSOCIATED MUTATION; LEUKOCYTE; NEUTROPHIL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; UNIPARENTAL DISOMY; AGED; AMINO ACID SEQUENCE; BLOOD; COHORT ANALYSIS; FEMALE; FOLLOW UP; GENETICS; LEUKEMIA; MALE; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROCEDURES; PROGNOSIS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; BASE SEQUENCE; COHORT STUDIES; DNA; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA; MALE; MOLECULAR SEQUENCE DATA; MUTATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS;

EID: 84937024098     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2015.13     Document Type: Letter

References (12)

1. Forsberg LA, Rasi C, Razzaghian HR, Pakalapati G, Waite L, Thilbeault KS, et al. Age-related somatic structural changes in the nuclear genome of human blood cells. Am J Hum Genet. 2012; 90: 217-228
2. Laurie CC, Laurie CA, Rice K, Doheny KF, Zelnick LR, McHugh CP, et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet. 2012; 44: 642-650
3. Jacobs KB, Yeager M, Zhou W, Wacholder S, Wang Z, Rodriguez-Santiago B, et al. Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet. 2012; 44: 651-658
4. Forsberg LA, Rasi C, Malmqvist N, Davies H, Pasupulati S, Pakalapati G, et al. Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet. 2014; 46: 624-628
5. Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012; 44: 1179-1181
6. Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med. 2014; 20: 1472-1478
7. Genovese G, Kahler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014; 371: 2477-2487
8. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014; 371: 2488-2498
9. Pang WW, Price EA, Sahoo D, Beerman I, Maloney WJ, Rossi DJ, et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA. 2011; 108: 20012-20017
10. Gale RE, Fielding AK, Harrison CN, Linch DC. Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age. Br J Haematol. 1997; 98: 512-519
11. Score J, Cross NC. Acquired uniparental disomy in myeloproliferative neoplasms. Hematol Oncol Clin North Am. 2012; 26: 981-991
12. Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010; 42: 722-726