The important role of FLT3-L in ex vivo expansion of hematopoietic stem cells following co-culture with mesenchymal stem cells

Cell Journal

Volumn 17, Issue 2, 2015, Pages 201-210

  Oubari, Farhad ^a,b   Amirizade, Naser ^a   Mohammadpour, Hemn ^c   Nakhlestani, Mozhdeh ^a   Zarif, Mahin Nikougoftar ^a  

^a HIGH INSTITUTE FOR RESEARCH AND EDUCATION IN TRANSFUSION MEDICINE   (Iran)

^b KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

Expansion; Fms related tyrosine kinase 3 ligand; Hematopoietic stem cells; Mesenchymal stem cells

Indexed keywords

ALPHA4 INTEGRIN; CD34 ANTIGEN; FLT3 LIGAND; HOX PROTEIN; HOXB4 PROTEIN; MESSENGER RNA; STEM CELL FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL COUNT; CELL ISOLATION; CFU COUNTING; COCULTURE; CONTROLLED STUDY; EX VIVO STUDY; EXPERIMENTAL STUDY; FEEDER CELL; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; PLACENTA; STEM CELL EXPANSION; STUDENT T TEST; UMBILICAL CORD BLOOD;

EID: 84937001183     PISSN: 22285806     EISSN: 22285814     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Smith C. Hematopoietic stem cells and hematopoiesis. Cancer Control. 2003;10(1): 9-16.
2. Martinez-Agosto JA, Mikkola HK, Hartenstein V, Banerjee U. The hematopoietic stem cell and its niche: a comparative view. Genes Dev. 2007; 21(23): 3044-3060.
3. Haylock DN, Nilsson SK. Osteopontin: a bridge between bone and blood. Br J Haematol. 2006; 134(5): 467-474.
4. Deutsch V, Hubel E, Kay S, Ohayon T, Katz B, Many A, et al. Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood. Br J Haematol. 2010; 149(1): 137-149.
5. Walenda T, Bokermann G, Ventura Ferreira MS, Piroth D, Hieronymus T, Neuss S. Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells. Exp Hematol. 2011; 39(6): 617-628.
6. Zhang Y, Chai C, Jiang XS, Teoh SH, Leong KW. Co-culture of umbilical cord blood CD34+ cells with human mesenchymal stem cells. Tissue Eng. 2006; 12(8): 2161-2170.
7. Solanilla A, Grosset C, Duchez P, Legembre P, Pitard V, Dupouy M, et al. Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)-4-and VLA-5-dependent mechanism. Br J Haematol. 2003; 120(5): 782-786.
8. Yao CL, Feng YH, Lin XZ, Chu IM, Hsieh TB, Hwang SM. Characterization of serum-free ex vivo-expanded hematopoietic stem cells derived from human umbilical cord blood CD133(+) cells. Stem Cells Dev. 2006; 15(1): 70-78.
9. Nikougoftar Zarif M, Soleimani M, Abolghasemi H, Amirizade N, Abroun S, Kaviani S. The high yield expansion and megakaryocytic differentiation of human umbilical cord blood CD133(+) cells. Cell J. 2011; 13(3): 173-178.
10. Brunstein C, Hirsch B, Hammerschmidt D, McGlennen R, Nguyen P, Verfaillie C. Leukemia in donor cells after allogeneic hematopoietic stem cell transplant. Bone Marrow Transplant. 2002; 29(12): 999-1003.
11. Celebi B, Mantovani D, Pineault N. Irradiated mesenchymal stem cells improve the ex vivo expansion of hematopoietic progenitors by partly mimicking the bone marrow endosteal environment. J Immunol Methods. 2011; 370(1-2): 93-103.
12. Li Y, Ma T, Kniss DA, Yang ST, Lasky LC. Human cord cell hematopoiesis in three-dimensional nonwoven fibrous matrices: in vitro simulation of the marrow microenvironment. J Hematother Stem Cell Res. 2001; 10(3): 355-368.
13. Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell. 2002; 109(1): 39-45.
14. Stanevsky A, Goldstein G, Nagler A. Umbilical cord blood transplantation: pros, cons and beyond. Blood Rev. 2009; 23(5): 199-204.
15. Heike T, Nakahata T. Ex vivo expansion of hematopoietic stem cells by cytokines. Biochim Biophys Acta. 2002; 1592(3): 313-321.
16. Kobari L, Pflumio F, Giarratana M, Li X, Titeus M, Izac C, et al. In vitro and in vivo evidence for the long-term multilineage (myeloid, B, NK, and T) reconstitution capacity of ex vivo expanded human CD34(+) cord blood cells. Exp Hematol. 2000; 28(12): 1470-1480.
17. Qian H, Tryggvason K, Jacobsen SE, Ekblom M. Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins. Blood. 2006; 107(9): 3503-3510.
18. White RL, Nash G, Kavanagh DP, Savage CO, Kalia N. Modulating the adhesion of haematopoietic stem cells with chemokines to enhance their recruitment to the ischaemically injured murine kidney. PLoS One. 2013; 8(6): e66489.
19. Hartz B, Volkmann T, Irle S, Loechelt C, Neubauer A, Brendel C. α4 integrin levels on mobilized peripheral blood stem cells predict rapidity of engraftment in patients receiving autologous stem cell transplantation. Blood. 2011; 118(8): 2362-2365.
20. Perdomo-Arciniegas AM, Vernot JP. Co-culture of hematopoietic stem cells with mesenchymal stem cells increases VCAM-1-dependent migration of primitive hematopoietic stem cells. Int J Hematol. 2011; 94(6): 525-532.
21. McNiece I, Harrington J, Turney J, Kellner J, Shpall E. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy. 2004; 6(4): 311-317.
22. Li T, Wu Y. Paracrine molecules of mesenchymal stem cells for hematopoietic stem cell niche. Bone Marrow Res. 2011; 2011: 353878.
23. Keller U, Gotze KS, Duyster J, Schmidt B, Rose-John S, Peschel C. Murine stromal cells producing hyper-interleukin-6 and Flt3 ligand support expansion of early human hematopoietic progenitor cells without need of exogenous growth factors. Leukemia. 2002; 16(10): 2122-2128.
24. Li L, Piloto O, Kim KT, Ye Z, Nguyen HB, Yu X, et al. FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells. Br J Haematol. 2007; 137(1): 64-75.
25. Buza-Vidas N, Cheng M, Duarte S, Charoudeh HN, Jacobsen SE, Sitnicka E. FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells. Blood. 2009; 113(15): 3453-3460.
26. Chaudhry UI, Katz SC, Kingham TP, Pillarisetty VG, Raab JR, Shah AB, et al. In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells. FASEB J. 2006; 20(7): 982-984.
27. McGinnis W, Krumlauf R. Homeobox genes and axial patterning. Cell. 1992; 68(2): 283-302.
28. Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002; 100(5): 1532-1542.