Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells

Experimental Hematology

Volumn 39, Issue 6, 2011, Pages 617-628

  Walenda, Thomas ^a   Bokermann, Gudrun ^a   Ventura Ferreira, Mónica S ^a   Piroth, Daniela M ^a   Hieronymus, Thomas ^a   Neuss, Sabine ^a   Zenke, Martin ^a   Ho, Anthony D ^b   Müller, Albrecht M ^c   Wagner, Wolfgang ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 5; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD34 ANTIGEN; FIBROBLAST GROWTH FACTOR 1; GROWTH FACTOR; SOMATOMEDIN BINDING PROTEIN 2; STEM CELL FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIVISION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IN VITRO STUDY; MESENCHYME; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; STROMA CELL; UMBILICAL CORD BLOOD;

ANIMALS; COCULTURE TECHNIQUES; DRUG SYNERGISM; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; IMMUNOPHENOTYPING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESODERM; MICE; MICE, INBRED NOD; MICE, SCID; STROMAL CELLS;

MURINAE; MUS;

EID: 79952813115     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2011.02.011     Document Type: Article

References (61)

1. Gratwohl A., Baldomero H., Schwendener A., et al. The EBMT activity survey 2007 with focus on allogeneic HSCT for AML and novel cellular therapies. Bone Marrow Transplant 2009, 43:275-291.
2. Broxmeyer H.E., Douglas G.W., Hangoc G., et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A 1989, 86:3828-3832.
3. Gluckman E., Broxmeyer H.A., Auerbach A.D., et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989, 321:1174-1178.
4. Stanevsky A., Shimoni A., Yerushalmi R., Nagler A. Cord blood stem cells for hematopoietic transplantation. Stem Cell Rev 2010, [Epub ahead of print].
5. Sullivan M.J. Banking on cord blood stem cells. Nat Rev Cancer 2008, 8:555-563.
6. Gluckman E., Rocha V., Boyer-Chammard A., et al. Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 1997, 337:373-381.
7. Rocha V., Labopin M., Sanz G., et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004, 351:2276-2285.
8. Barker J.N., Weisdorf D.J., DeFor T.E., et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005, 105:1343-1347.
9. Magro E., Regidor C., Cabrera R., et al. Early hematopoietic recovery after single unit unrelated cord blood transplantation in adults supported by co-infusion of mobilized stem cells from a third party donor. Haematologica 2006, 91:640-648.
10. Christopherson K.W., Hangoc G., Mantel C.R., Broxmeyer H.E. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004, 305:1000-1003.
11. Szabo E., Rampalli S., Risueno R.M., et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 2010, 25:521-525.
12. Ho A.D., Wagner W. The beauty of asymmetry-asymmetric divisions and self-renewal in the hematopoietic system. Curr Opin Hematol 2007, 14:330-336.
13. Schiedlmeier B., Santos A.C., Ribeiro A., et al. HOXB4's road map to stem cell expansion. Proc Natl Acad Sci U S A 2007, 104:16952-16957.
14. Sauvageau G., Humphries R.K. Medicine. The blood stem cell Holy Grail?. Science 2010, 329:1291-1292.
15. Boitano A.E., Wang J., Romeo R., et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010, 329:1345-1348.
16. Robinson S., Niu T., de Lima M., et al. Ex vivo expansion of umbilical cord blood. Cytotherapy 2005, 7:243-250.
17. Zhang C.C., Kaba M., Iizuka S., Huynh H., Lodish H.F. Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood 2008, 111:3415-3423.
18. Levac K., Karanu F., Bhatia M. Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo. Haematologica 2005, 90:166-172.
19. de Haan G., Weersing E., Dontje B., et al. In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1. Dev Cell 2003, 4:241-251.
20. Hintze C., Ruster B., Seifried E., Henschler R. Platelet precursor cells can be generated from cultured human CD34+ progenitor cells but display recirculation into hematopoietic tissue upon transfusion in mice. Transfus Med Hemother 2010, 37:185-190.
21. Pineault N., Cortin V., Boyer L., et al. Individual and synergistic cytokine effects controlling the expansion of cord blood CD34(+) cells and megakaryocyte progenitors in culture. Cytotherapy 2010 Nov 19, [Epub ahead of print].
22. Shpall E.J., Quinones R., Giller R., et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002, 8:368-376.
23. Zhang C.C., Kaba M., Ge G., et al. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med 2006, 12:240-245.
24. Huynh H., Iizuka S., Kaba M., et al. Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells 2008, 26:1628-1635.
25. Dexter T.M., Allen T.D., Lajtha L.G., Schofield R., Lord B.I. Stimulation of differentiation and proliferation of haemopoietic cells in vitro. J Cell Physiol 1973, 82:461-473.
26. Mendez-Ferrer S., Michurina T.V., Ferraro F., et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010, 466:829-834.
27. Bakhshi T., Zabriskie R.C., Bodie S., et al. Mesenchymal stem cells from the Wharton's jelly of umbilical cord segments provide stromal support for the maintenance of cord blood hematopoietic stem cells during long-term ex vivo culture. Transfusion 2008, 48:2638-2644.
28. Robinson S.N., Ng J., Niu T., et al. Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant 2006, 37:359-366.
29. McNiece I., Harrington J., Turney J., Kellner J., Shpall E.J. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy 2004, 6:311-317.
30. Kadereit S., Deeds L.S., Haynesworth S.E., et al. Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34(+)/CD38(-) early progenitors cultured over human MSCs as a feeder layer. Stem Cells 2002, 20:573-582.
31. Wagner W., Roderburg C., Wein F., et al. Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors. Stem Cells 2007, 10:2638-2657.
32. Wagner W., Wein F., Roderburg C., et al. Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction. Exp Hematol 2007, 35:314-325.
33. Wagner W., Saffrich R., Ho A.D. The stromal function of mesenchymal stromal cells. Transf Med Hemotherapy 2008, 35:185-193.
34. Walenda T., Bork S., Horn P., et al. Co-culture with mesenchymal stromal cells increases proliferation and maintenance of hematopoietic progenitor cells. J Cell Mol Med 2010, 14:337-350.
35. da Silva C.L., Goncalves R., Crapnell K.B., Cabral J.M., Zanjani E.D., Meida-Porada G. A human stromal-based serum-free culture system supports the ex vivo expansion/maintenance of bone marrow and cord blood hematopoietic stem/progenitor cells. Exp Hematol 2005, 33:828-835.
36. Dominici M., Le Blanc K., Mueller I., et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8:315-317.
37. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1978, 4:7-25.
38. Battiwalla M., Hematti P. Mesenchymal stem cells in hematopoietic stem cell transplantation. Cytotherapy 2009, 11:503-515.
39. Li N., Feugier P., Serrurrier B., et al. Human mesenchymal stem cells improve ex vivo expansion of adult human CD34+ peripheral blood progenitor cells and decrease their allostimulatory capacity. Exp Hematol 2007, 35:507-515.
40. Weisel K.C., Moore M.A., Kanz L., Mohle R. Extended in vitro expansion of adult, mobilized CD34+ cells without significant cell senescence using a stromal cell coculture system with single cytokine support. Stem Cells Dev 2009, 18:229-234.
41. Khoury M., Drake A., Chen Q., et al. Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev 2011 Jan 31, [Epub ahead of print].
42. Delaney C., Heimfeld S., Brashem-Stein C., Voorhies H., Manger R.L., Bernstein I.D. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010, 16:232-236.
43. Calvi L.M., Adams G.B., Weibrecht K.W., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003, 425:841-846.
44. Wein F., Pietsch L., Saffrich R., et al. N-Cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells. Stem Cell Res 2010, 4:129-139.
45. Andrade P.Z., dos Santos F., Almeida-Porada G., da Silva C.L., S Cabral J.M. Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells. Mol Biosyst 2010, 6:1207-1215.
46. Horn P., Bokermann G., Cholewa D., et al. Comparison of individual platelet lysates for isolation of human mesenchymal stromal cells. Cytotherapy 2010, 12:888-898.
47. Schallmoser K., Bartmann C., Rohde E., et al. Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion 2007, 47:1436-1446.
48. Oostendorp R.A., Audet J., Eaves C.J. High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo. Blood 2000, 95:855-862.
49. Mishima S., Nagai A., Abdullah S., et al. Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent. Eur J Haematol 2010, 84:538-546.
50. Zhang J., Niu C., Ye L., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003, 425:836-841.
51. Wilson A., Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 2006, 6:93-106.
52. Ho A.D., Wagner W., Franke W. Heterogeneity of mesenchymal stromal cell preparations. Cytotherapy 2008, 10:320-330.
53. Wagner W., Ho A.D. Mesenchymal stem cell preparations-comparing apples and oranges. Stem Cell Rev 2007, 3:239-248.
54. Wagner W., Ho A.D., Zenke M. Different facets of aging in human mesenchymal stem cells. Tissue Eng Part B Rev 2010, 16:445-453.
55. Wagner W., Feldmann R.E., Seckinger A., et al. The heterogeneity of human mesenchymal stem cell preparations-Evidence from simultaneous analysis of proteomes and transcriptomes. Exp Hematol 2006, 34:536-548.
56. Reinisch A., Hofmann N.A., Obenauf A.C., et al. Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo. Blood 2009, 113:6716-6725.
57. Lyons A.B., Parish C.R. Determination of lymphocyte division by flow cytometry. J Immunol Methods 1994, 171:131-137.
58. Gotze K.S., Schiemann M., Marz S., et al. CD133-enriched CD34(-) (CD33/CD38/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression. Exp Hematol 2007, 35:1408-1414.
59. Andre M.C., Erbacher A., Gille C., et al. Long-term human CD34+ stem cell-engrafted nonobese diabetic/SCID/IL-2R gamma(null) mice show impaired CD8+ T cell maintenance and a functional arrest of immature NK cells. J Immunol 2010, 185:2710-2720.
60. Liu Y., Yi L., Zhang X., et al. Cotransplantation of human umbilical cord blood-derived stromal cells enhances hematopoietic reconstitution and engraftment in irradiated BABL/c mice. Cancer Biol Ther 2011, 11:84-94.
61. Kelly S.S., Sola C.B., de Lima M., Shpall E. Ex vivo expansion of cord blood. Bone Marrow Transplant 2009, 44:673-681.