Low serum testosterone level was associated with extensive coronary artery calcification in elderly male patients with stable coronary artery disease

Coronary Artery Disease

Volumn 26, Issue 5, 2015, Pages 437-441

  Lai, Jiangtao ^a   Ge, Yuhua ^a   Shao, Yunfei ^a   Xuan, Tianming ^a   Xia, Shudong ^a   Li, Ming ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

androgen; atherosclerosis; calcium deposition

Indexed keywords

CALCIUM; TESTOSTERONE; BIOLOGICAL MARKER;

AGED; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CORONARY ARTERY CALCIFICATION; CORONARY ARTERY CALCIUM SCORE; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; DISEASE ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; PROGNOSIS; TESTOSTERONE BLOOD LEVEL; AGE; BLOOD; BLOOD VESSEL CALCIFICATION; CHI SQUARE DISTRIBUTION; CHINA; CORONARY ANGIOGRAPHY; CORONARY STENOSIS; DEFICIENCY; ODDS RATIO; PROCEDURES; RADIOGRAPHY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; SEX DIFFERENCE; STATISTICAL MODEL;

AGE FACTORS; AGED; BIOMARKERS; CHI-SQUARE DISTRIBUTION; CHINA; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY STENOSIS; HUMANS; LOGISTIC MODELS; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; ODDS RATIO; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; TESTOSTERONE; VASCULAR CALCIFICATION;

EID: 84936952358     PISSN: 09546928     EISSN: 14735830     Source Type: Journal    
DOI: 10.1097/MCA.0000000000000260     Document Type: Article

References (38)

1. Vliegenthart R, Oudkerk M, Hofman A, Oei HH, van Dijck W, van Rooij FJ, et al. Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation 2005; 112:572-577.
2. Moussa I, Ellis SG, Jones M, Kereiakes DJ, McMartin D, Rutherford B, et al. Impact of coronary culprit lesion calcium in patients undergoing paclitaxeleluting stent implantation (a TAXUS-IV sub study). Am J Cardiol 2005; 96:1242-1247.
3. Krone RJ, Shaw RE, Klein LW, Blankenship JC, Weintraub WS. American College of Cardiology-National Cardiovascular Data Registry. Ad hoc percutaneous coronary interventions in patients with stable coronary artery disease-a study of prevalence, safety, and variation in use from the American College of Cardiology National Cardiovascular Data Registry (ACC-NCDR). Catheter Cardiovasc Interv 2006; 68:696-703.
4. Abdel-Wahab M, Richardt G, Joachim Büttner H, Toelg R, Geist V, Meinertz T, et al. High-speed rotational atherectomy before paclitaxel-eluting stent implantation in complex calcified coronary lesions: the randomized ROTAXUS (Rotational Atherectomy Prior to Taxus Stent Treatment for Complex Native Coronary Artery Disease) trial. J Am Coll Cardiol Cardiovasc Interv 2013; 6:10-19.
5. Demer LL, Tintut Y. Vascular calcification: pathobiology of a multifaceted disease. Circulation 2008; 117:2938-2948.
6. Bagger YZ, Tanko LB, Alexandersen P, Qin G, Christiansen C. Prospective Epidemiological Risk Factors Study Group. Radiographic measure of aorta calcification is a site-specific predictor of boneloss and fracture risk at the hip. J Intern Med 2006; 259:598-605.
7. Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation: a possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol 1997; 17:680-687.
8. Shao JS, Cheng SL, Pingsterhaus JM, Charlton-Kachigian N, Loewy AP, Towler DA. Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest 2005; 115:1210-1220.
9. Leder BZ, Finkelstein JS. Gonadal steroids and the skeleton in men. Clinical aspects. In: Orwoll ES, Bliziotes M, editors. Osteoporosis pathophysiology and clinical management. Totowa, NJ: Humana Press; 2002. pp. 393-411.
10. Kenny AM, Raisz LG. Androgens and bone. In: Bagatell CJ, Bremner WJ, editors. Androgens in health and disease. Totawa, NJ: Humana Press; 2003. pp. 221-232.
11. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C. Androgens and bone. Endocr Rev 2004; 25:389-425.
12. Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP, et al. European Association of Urology. EAU guidelines on prostate cancer. Eur Urol 2008; 53:68-80.
13. Fink HA, Ewing SK, Ensrud KE, Barrett-Connor E, Taylor BC, Cauley JA, et al. Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men. J Clin Endocrinol Metab 2006; 91:3908-3915.
14. Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA. Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease. J Clin Endocrinol Metab 2005; 90:1041-1046.
15. Park BJ, Shim JY, Lee YJ, Lee JH, Lee HR. Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in nonobese Korean men. Asian J Androl 2012; 14:612-615.
16. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15:827-832.
17. Shaw LJ, Raggi P, Schisterman E, Berman DS, Callister TQ. Prognostic value of cardiac risk factors and coronary artery calcium screening for allcause mortality. Radiology 2003; 228:826-833.
18. Pletcher MJ, Tice JA, Pignone M, Browner WS. Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and metaanalysis. Arch Intern Med 2004; 164:1285-1292.
19. Silverman MG, Blaha MJ, Krumholz HM, Budoff MJ, Blankstein R, Sibley CT, et al. Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the multi-ethnic study of atherosclerosis. Eur Heart J 2014; 35:2232-2241.
20. Muller M, den Tonkelaar I, Thijssen JH, Grobbee DE, van der Schouw YT. Endogenous sex hormones in men aged 40-80 years. Eur J Endocrinol 2003; 149:583-589.
21. Hak AE, Witteman JC, de Jong FH, Geerlings MI, Hofman A, Pols HA. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab 2002; 87:3632-3639.
22. Webb CM, Collins P. Testosterone and coronary artery disease in men. Maturitas 2010; 67:15-19.
23. Cornoldi A, Caminiti G, Marazzi G, Vitale C, Patrizi R, Volterrani M, et al. Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease. Int J Cardiol 2010; 142:50-55.
24. Martin AC. Osteoporosis in men: a review of endogenous sex hormones and testosterone replacement therapy. J Pharm Pract 2011; 24:307-315.
25. Francis RM. The effects of testosterone on osteoporosis in men. Clin Endocrinol (Oxf) 1999; 50:411-414.
26. Colvard DS, Eriksen EF, Keeting PE, Wilson EM, Lubahn DB, French FS, et al. Identification of androgen receptors in normal human osteoblast like cells. Proc Natl Acad Sci USA 1989; 86:854-857.
27. Anderson FH, Francis RM, Selby PL, Cooper C. Sex hormones and osteoporosis in men. Calcif Tissue Int 1998; 62:185-188.
28. Francis RM, Peacock M, Aaron JE, Selby PL, Taylor GA, Thompson J, et al. Osteoporosis in hypogonadal men: role of decreased plasma 1, 25-dihydroxyvitamin D, calcium malabsorption and low bone formation. Bone 1986; 7:261-268.
29. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 2006; 99:1044-1059.
30. Speer MY, Li X, Hiremath PG, Giachelli CM. Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis. J Cell Biochem 2010; 110:935-947.
31. Miller VM, Mulvagh SL. Sex steroids and endothelial function: translating basic science to clinical practice. Trends Pharmacol Sci 2007; 28:263-270.
32. Foresta C, Zuccarello D, De Toni L, Garolla A, Caretta N, Ferlin A. Androgens stimulate endothelial progenitor cells through an androgen receptormediated pathway. Clin Endocrinol (Oxf) 2008; 68:284-289.
33. Simon D, Charles MA, Nahoul K, Qrssaud G, Kremshi J, Hully V, et al. Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the Telecom study. J Clin Endocrinol Metab 1997; 82:682-685.
34. Fogari R, Preti P, Zoppi A, Fogari E, Rinaldi A, Corradi L, et al. Serum testosterone levels and arterial blood pressure in the elderly. Hypertens Res 2005; 28:625-630.
35. Madhavan MV, Tarigopula M, Mintz GS, Maehara A, Stone GW, Généreux P. Coronary artery calcification: pathogenesis and prognostic implications. J Am Coll Cardiol 2014; 63:1703-1714.
36. Kondos GT, Hoff JA, Sevrukov A, Daviglus ML, Garside DB, Devries SS, et al. Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low-to intermediaterisk adults. Circulation 2003; 107:2571-2576.
37. Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA, et al. Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation 2001; 104:412-417.
38. Graham G, Blaha MJ, Budoff MJ, Rivera JJ, Agatston A, Raggi P, et al. Impact of coronary artery calcification on all-cause mortality in individuals with and withouthypertension. Atherosclerosis 2012; 225:432-437.