Sex Hormones and Osteoporosis in Men

Calcified Tissue International

Volumn 62, Issue 3, 1998, Pages 185-188

  Anderson, F H ^a   Francis, R M ^b   Selby, P L ^c   Cooper, C ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; ANDROGEN; ESTROGEN;

ANDROGEN DEFICIENCY; BONE DENSITY; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; EDITORIAL; ESTROGEN DEFICIENCY; HUMAN; LUMBAR SPINE; MALE; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; TRABECULAR BONE; ANIMAL; MIDDLE AGED; PATHOLOGIC FRACTURE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANDROGENS; ANIMALS; ESTROGENS; FRACTURES, SPONTANEOUS; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS;

EID: 0032014905     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s002239900414     Document Type: Editorial

References (41)

1. Melton LJ, Chrischilles EA, Cooper C, Lane AW, Riggs BL (1992) How many women have osteoporosis? J Bone Miner Res 7:1005–1010
2. Baillie SP, Davison CE, Johnson FJ, Francis RM (1992) Pathogenesis of vertebral crush fractures in men. Age Ageing 21:139–141
3. Jackson JA, Spiekerman AM (1989) Testosterone deficiency is common in men with hip fracture after simple falls. Clin Res 37:131–136
4. Stanley HL, Schmitt BP, Poses RM, Deiss WP (1991) Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 39:766–771
5. Colvard DS, Eriksen EF, Keeting PE, Wilson EM, Lubahn DB, French FS, Riggs BL, Spelsberg TC (1989) Identification of androgen receptors in normal human osteoblast-like cells. Proc Natl Acad Sci 86:854–857
6. Orwoll ES, Stribrska L, Ramsey EE, Keenan EJ (1991) Androgen receptors in osteoblast-like cell lines. Calcif Tissue Int 49:183–187
7. Benz DJ, Haussler MR, Thomas MA, Speelman B, Komm BS (1991) High-affinity androgen binding and androgenic regulation of alpha 1(I)-procollagen and transforming growth factor-beta steady state messenger ribonucleic acid levels in human osteoblast-like osteosarcoma cells. Endocrinology 128(6):2723–2730
8. Bruch HB, Wolf L, Budde R, Romalo G, Schweikert HU (1992) Androstenedione metabolism in cultured human osteoblast-like cells. J Clin Endocrinol Metab 75:101–105
9. Abu EO, Kusec V, Triffit JT, Compston JE (1996) The localisation of androgen receptors in human bone. J Bone Miner Res 11 (suppl 1):9
10. Coxam V, Robins S, Pastoureau P, Gaumet N, Lebecque P, Davicco MJ, Giry J, Barlet JP (1995) Estrogen is more efficient than dihydrotestosterone to prevent bone loss in young castrated male rats. J Bone Miner Res 10 (suppl 1):S311
11. Horowitz M, Wishart JM, O'Loughin PD, Morris HA, Need AG, Nordin BEC (1992) Osteoporosis and Klinefelter's syndrome. Clin Endocrinol 36:113–118
12. Finkelstein JS, Klibanski A, Neer RM, Doppelt SH, Rosenthal DI, Segre GV, Crowley WF (1989) Increases in bone density during treatment of men with idiopathic hypogonadotrophic hypogonadism. J Clin Endocrinol Metab 69:776–783
13. Štěpán JJ, Lachman M, Zvěřina J, Pacovský V, Baylink DJ (1989) Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodelling. J Clin Endocrinol Metab 69:523–527
14. Foresta C, Busnardo B, Ruzza G, Zanatta G, Mioni R (1983) Lower calcitonin levels in young hypogonadic men with osteoporosis. Horm Metab Res 15:206–207
15. Francis RM, Peacock M, Aaron JE, Selby PL, Taylor GA, Thompson J et al (1986) Osteoporosis in hypogonadal men: role of decreased plasma 1,25-dihydroxy-vitamin D, calcium malabsorption and low bone formation. Bone 7:261–268
16. Khaw KT, Barrett-Connor E (1991) Endogenous sex hormones, high density lipoprotein cholesterol and other lipoprotein fractions in men. Arteriosclerosis Thromb 11:489–494
17. Anderson DC (1974) Sex hormone binding globulin. Clin Endocrinol 3:69–96
18. Bagatell CJ, Knopp RH, Rivier JE, Bremner WJ (1994) Physiological levels of estradiol stimulate plasma high density lipoprotein 2 cholesterol levels in normal men. J Clin Endocrinol Metab 78:855–861
19. Zmuda JM, Fahrenbach MC, Younkin BT, Bausserman LL, Terry RB, Catlin DH, Thompson PD (1993) The effect of testosterone aromatization on high density lipoprotein cholesterol level and postheparin lipolytic activity. Metab Clin Exper 42:446–450
20. Vanderschueren D, Bouillon R (1995) Androgens and bone. Calcif Tissue Int 56:341–346
21. Benz DJ, Haussler MR, Komm BS (1991) Estrogen binding and estrogenic responses in normal human osteoblast-like cells. J Bone Miner Res 6(6):531–51
22. Purohit A, Flanagan AM, Reed MJ (1992) Estrogen synthesis by osteoblast cell lines. Endocrinology 131(4):2027–2029
23. Baris C, Leung P, Selby PL, Carter DH, Freemont AJ, Braidman IP (1996) Estrogen target cells in bone from men and women. J Bone Mineral Res 11 (suppl 1):S221
24. Bernecker PM, Willvonseder R, Resch H (1995) Decreased estrogen levels in patients with primary osteoporosis. J Bone Miner Res 10 (suppl 1):T364
25. Francis RM, Peacock M, Marshall DH, Horsman A, Aaron JE (1989) Spinal osteoporosis in men. Bone Miner 5:347–357
26. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K (1995) Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80:3689–3698
27. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B et al (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056–1061
28. Soule SG, Conway G, Prelevic GM, Prentice M, Ginsburg J, Jacobs HS (1995) Osteopenia as a feature of the androgen insensitivity syndrome. Clin Endocrinol 43:671–676
29. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER (1997) Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337:91–95
30. Anderson FH, Francis RM, Hindmarsh P, Fall C, Cooper C (1996) Serum oestradiol in osteoporotic and normal men is related to bone mineral density. In: Papapoulos SE, Lips P, Pols HAP, Johnston CC, Delmas PD (eds). Osteoporosis 1996—Proceedings of the 1996 World Congress on Osteoporosis. Elsevier, Amsterdam, pp 377–381
31. Slemenda C, Zhou L, Longcope C, Hui S, Johnston CC (1995) Sex steroids, bone mass and bone loss in older men: estrogens or androgens? J Bone Miner Res 10 (suppl 1):S44
32. Slemenda C, Longcope C, Hui S, Zhou L, Johnston CC (1996) Estrogens but not androgens are positively associated with bone mass in older men. Osteoporosis Int 6 (suppl 1):139
33. Selby PL, Braidman IP, Mawer EB, Freemont AJ (1996) Hormonal influences in male osteoporosis. Osteoporosis Int 6 (suppl 1):279
34. Selby PL, Braidman IP, Freemont AJ, Mawer EB (1995) Is estrogen an important regulator of bone turnover in the male? Preliminary evidence from osteoporosis. J Endocrinol 1 (suppl 1):O54
35. Anderson FH, Francis RM, Peaston RT, Wastell HJ (1997) Androgen therapy in eugonadal men with osteoporosis—effects of six months’ treatment on markers of bone formation and resorption. J Bone Miner Res 12(3):472–478
36. Nawata H, Tanaka S, Takayanagi R, Sakai Y, Yanase T, Ikuyama S, Haji M (1995) Aromatase in bone cell—association with osteoporosis in postmenopausal women. J Steroid Biochem Mol Biol 53:165–174
37. Kasperk CH, Wakley GK, Hierl T, Ziegler R (1997) Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J Bone Miner Res 12:464–471
38. Szathmari M, Szucs J, Feher T, Hollo I (1994) Dehydroepiandrosterone-sulfate and bone mineral density. Osteoporosis Int 4:84–88
39. Barrett-Connor E, Kritz-Silverstein D, Edelstein SL (1993) A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women. Am J Epidemiol 137:201–206
40. Hamdy RC, Cancellaro LA, Moore SW (1996) The use of anabolic steroids in the management of osteoporosis in men aged 65 years and over. Age Ageing 25 (suppl 1):2
41. Ringe JD, Kipshoven C, Rovati L (1996) Therapy of idiopathic male osteoporosis: a 3-year study with calcium and low dose intermittent monofluorophosphate. In: Papapoulos SE, Lips P, Pols HAP, Johnson CC (eds) Osteoporosis 1996—Proceedings of the World Congress on Osteoporosis. Elsevier, Amsterdam, pp 383–390