Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection

Histology and Histopathology

Volumn 30, Issue 7, 2015, Pages 833-839

  Morbini, Patrizia ^a,b   Capello, Gianluca ^b   Alberizzi, Paola ^b   Benazzo, Marco ^a   Paglino, Chiara ^b   Comoli, Patrizia ^b   Pedrazzoli, Paolo ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Anterior gradient 2; Cytokeratin 7; HPV associated oropharyngeal carcinoma; Squamocolumnar junction; Tonsillar crypt

Indexed keywords

HUMAN PAPILLOMAVIRUS;

AGR2 PROTEIN, HUMAN; BIOLOGICAL MARKER; CD63 ANTIGEN; CD63 PROTEIN, HUMAN; CYTOKERATIN 7; GDA PROTEIN, HUMAN; GUANINE DEAMINASE; MATRILYSIN; MMP7 PROTEIN, HUMAN; PROTEIN;

CARCINOMA, SQUAMOUS CELL; COMPLICATION; CYTOLOGY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PALATINE TONSIL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTION; PATHOGENICITY; PATHOLOGY;

ANTIGENS, CD63; BIOMARKERS; CARCINOMA, SQUAMOUS CELL; FEMALE; GUANINE DEAMINASE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-7; MALE; MATRIX METALLOPROTEINASE 7; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PALATINE TONSIL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PROTEINS;

EID: 84936950863     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: 10.14670/HH-11-590     Document Type: Article

References (27)

1. Andersen A.S., Koldjaer Sølling A.S., Ovesen T. and Rusan M. (2014). The interplay between HPV and host immunity in head and neck squamous cell carcinoma. Int. J. Cancer 134, 2755-2763.
2. Brychtova V., Vojtesek B. and Hrstka R. (2011). Anterior gradient 2: a novel player in tumor cell biology. Cancer Lett. 304, 1-7.
3. Chen Y.T., Ho C.L., Chen P.K., Chen Y.L. and Chang C.F. (2013). Anterior gradient 2: a novel sensitive tumor marker for metastatic oral cancer. Cancer Lett. 339, 270-278
4. Choi G., Suh Y.L., Lee H.M., Jung K.Y. and Hwang S.J. (1996). Prenatal and postnatal changes of the human tonsillar crypt epithelium. Acta Otolaryngol. Suppl. 523, 8-33.
5. Clarke L.E., Conway A.B., Warner N.M., Barnwell P.N., Sceppa J. and Helm K.F. (2013). Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma. J. Cutan. Pathol. 40, 646-650.
6. Herfs M., Yamamoto Y., Laury A., Wang X., Nucci M.R., McLaughlin- Drubin M.E., Münger K., Feldman S., McKeon F.D., Xian W. and Crum C.P. (2012). A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc. Natl. Acad. Sci. USA 109, 10516-10521.
7. Horvath C.A., Boulet G.A., Renoux V.M., Delvenne P.O. and Bogers J.P. (2010). Mechanisms of cell entry by human papillomaviruses: an overview. Virol. J. 7, 11.
8. Hosoya A., Kwak S., Kim E.J., Lunny D.P., Lane E.B., Cho S.W. and Jung H.S. (2010). Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm. Anat. Rec. 293, 1864-1872.
9. Jemal A., Simard E.P., Dorell C., Noone A.M., Markowitz L.E., Kohler B., Eheman C., Saraiya M., Bandi P., Saslow D., Cronin K.A., Watson M., Schiffman M., Henley S.J., Schymura M.J., Anderson R.N., Yankey D. and Edwards B.K. (2013). Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels. J. Natl. Cancer Inst. 105, 175-201.
10. Jordan R.C., Lingen M.W., Perez-Ordonez B., He X., Pickard R., Koluder M., Jiang B., Wakely P., Xiao W. and Gillison M.L. (2012). Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials. Am. J. Surg. Pathol. 36, 945-954.
11. Joseph A.W. and D’Souza G. (2012). Epidemiology of human papillomavirus-related head and neck cancer. Otolaryngol. Clin. N. Am. 45, 139-164.
12. Jung A.C., Briolat J., Millon R., de Reyniès A., Rickman D., Thomas E., Abecassis J., Clavel C. and Wasylyk B. (2010). Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. Int. J. Cancer 126, 1882-1894.
13. Kim S.H., Koo B.S., Kang S., Park K., Kim H., Lee K.R., Lee M.J., Kim J.M., Choi E.C. and Cho N.H. (2007). HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. Int. J. Cancer 120, 1418-1425.
14. Kines R.C., Thompson C.D., Lowy D.R., Schiller J.T. and Day P.M. (2009). The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding. Proc. Natl. Acad. Sci. USA 106, 20458-20463.
15. Lajer C.B., Garnaes E., Friis-Hansen L., Norrild B., Therkildsen M.H., Glud M., Rossing M., Lajer H., Svane D., Skotte L., Specht L., Buchwald C. and Nielsen F.C. (2012). The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPVrelated head and neck cancer and cervical cancer. Br. J. Cancer 106, 526-534.
16. Lepreux S., Bioulac-Sage P. and Chevet E. (2011). Differential expression of the anterior gradient protein-2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree. Liver Inter. 31, 322-328.
17. Määttä M., Liakka A., Salo S., Tasanen K., Bruckner-Tuderman L. and Autio-Harmainen H. (2004). Differential expression of basement membrane components in lymphatic tissues. J. Histochem. Cytochem. 52, 1073-1081.
18. Marur S., D’Souza G., Westra W.H. and Forastiere A (2010). HPV- associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 11, 781-789.
19. Morbini P., Dal Bello B., Alberizzi P., Mannarini L., Tinelli C., Mevio N., Garotta M., Mura F., Bertino G and Benazzo M. (2013). Oral HPV infection and persistence in patients with head and neck cancer. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 116, 474-484.
20. Pohler E., Craig A.L., Cotton J., Lawrie L., Dillon J.F., Ross P., Kernohan N. and Hupp T.R. (2004). The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage. Mol. Cell. Proteomics 3, 534-547.
21. Pyeon D., Newton M.A., Lambert P.F., den Boon J.A., Sengupta S., Marsit C.J., Woodworth C.D., Connor J.P., Haugen T.H., Smith E.M., Kelsey K.T., Turek L.P. and Ahlquist P. (2007). Fundamental differences in cell cycle deregulation in human papillomaviruspositive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res. 67, 4605-4619.
22. Rautava J. and Syrjänen S. (2012). Biology of human papillomavirus infections in head and neck carcinogenesis. Head Neck Pathol. 6, S3-15.
23. Sapp M. and Bienkowska-Haba M. (2009). Viral entry mechanisms: human. papillomavirus and a long journey from extracellular matrix to the nucleus. FEBS J. 276, 7206-7216.
24. Sweeny L., Liu Z., Bush B.D., Hartman Y., Zhou T. and Rosenthal E.L. (2012). CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma. Exp. Cell Res. 318, 1788-1798.
25. von Gaudecker B. (1988). Development and functional anatomy of the human tonsilla palatina. Acta Otolaryngol. Suppl. 454, 28-32.
26. Wilting S.M., Smeets S.J., Snijders P.J., van Wieringen W.N., van de Wiel M.A., Meijer G.A., Ylstra B., Leemans C.R., Meijer C.J., Brakenhoff R.H., Braakhuis B.J. and Steenbergen R.D. (2009). Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck. BMC Medical Genomics 2, 32.
27. Yamada A., Sasaki H., Aoyagi K., Sano M., Fujii S., Daiko H., Nishimura M., Yoshida T., Chiba T. and Ochiai A. (2008). Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous cell carcinoma of the esophagus. Oncol. Rep. 20, 1021-1027.