Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest

Journal of Pharmacological Sciences

Volumn 127, Issue 3, 2015, Pages 332-338

  Chen, Weiqiang ^a   Liu, Ying ^a   Li, Ming ^a   Mao, Jianwen ^a   Zhang, Lirong ^a   Huang, Rongbo ^a   Jin, Xiaobao ^a   Ye, Lianbao ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

BEL 7402 cells; In vitro and in vivo; Liver cancer; Mechanism; Pinene

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN B; CYCLIN DEPENDENT KINASE 1; FLUOROURACIL; PINENE; PROTEIN TYROSINE PHOSPHATASE; ALPHA-PINENE; ANTINEOPLASTIC AGENT; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; PROTEIN KINASE; TERPENE; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; G2 PHASE CELL CYCLE CHECKPOINT; HEPATOCELLULAR CARCINOMA CELL LINE; HISTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MASS FRAGMENTOGRAPHY; MOUSE; NEWBORN; NONHUMAN; PINE; PROTEIN EXPRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; CANCER TRANSPLANTATION; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; LIVER NEOPLASMS; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYTOTHERAPY; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CHECKPOINT KINASE 2; CYCLIN B; CYCLIN-DEPENDENT KINASES; DOWN-REGULATION; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LIVER NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; MICE, NUDE; MONOTERPENES; NEOPLASM TRANSPLANTATION; PHYTOTHERAPY; PINUS; PLANT OILS; PROTEIN KINASES; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84936946582     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2015.01.008     Document Type: Article

References (23)

1. Center MM, Jemal A. International trends in liver cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 2011;20:2362-2368.
2. Chen JG, Zhang SW. Liver cancer epidemic in China: past, present and future. Semin Cancer Biol. 2011;21:59-69.
3. McGlynn KA, London WT. The global epidemiology of hepatocellular carcinoma: present and future. Clin Liver Dis. 2011;15:223-243.
4. Li P, Liu YP. The research progress of pine needles. J Chengdu Univ Traditional Chin Med. 2001;24:49-50.
5. Li SZ, editor. Compendium of Materia Medica (Rudin). first ed. Beijing: People's Medical Publishing House; 1982. p. 882-917.
6. Politeo O, Skocibusic M, Maravic A, Ruscic M, Milos M. Chemical composition and antimicrobial activity of the essential oil of endemic Dalmatian black pine (Pinus nigra ssp. Dalmatica). Chem Biodivers. 2011;8:540-547.
7. Chen WQ, Xu B, Mao JW, Wei FX, Li M, Liu T, et al. Inhibitory effects of a-pinene on hepatoma carcinoma cell proliferation. Asian Pac J Cancer Prev. 2014;7:3293-3297.
8. Chen QS, Zheng DY. To direct extract the industry pinene through continuous distillation of turpentine. Journal of Fujian Teachers University (Natural Science). 2002;18:56-60.
9. Sing HP, Batish DR, Kaur S, Arora K. alpha-Pinene inhibits growth and induces oxidative stress in roots. Ann Bot. 2006;98:1261-1269.
10. Yang CY, Cui YD. Evaluation of MTT method for quantification of microbial cell viability in microplates. Acta Hydrobiol Sin. 2009;33:557-580.
11. Zhou JF, Chen G, Lu YP, Wang SX, Mar. D. Experimental studies of recombinant adenovirus thymidine kinase gene construct compare with acyclovir for treating transplanted tumors in nude mice lung. Chin J Onco. 2004;26:68-70.
12. Su YL, Wang CY, Tuo Y, Su XL. The effects of anticancer bioactive peptide on inhibitory action for H22 transplantation tumor growth. J Baotou Med Coll. 2011;27:1-3.
13. Hyka-Nouspikel N, Desmarais J, Gokhale PJ, Jones M, Meuth M, Andrews PW, et al. Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells. Stem Cells. 2012;30:1901-1910.
14. Zhao Y, Lou IC, Conolly RB. Computational modeling of signaling pathways mediating cell cycle checkpoint control and apoptotic responses to ionizing radiation-induced DNA damage. Dose Response. 2012;10:251-273.
15. Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt L, Voit R. Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. PLoS One. 2011;6:14711.
16. Tsui MM, Tai WC, Wong WY, Hsiao WL. Selective G2/M arrest in a p53 (Val135) - transformed cell line induced by lithium is mediated through an intricate network of MAPK and b-catenin signaling pathways. Life Sci. 2012;91:312-321.
17. Hseu YC, Lee MS, Wu CR, Cho HJ, Lin KY, Lai CH, et al. The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. J Agric Food Chem. 2012;60:2385-2397.
18. Bunz F, Dutriaux A, Lengauer C, Weldman TS, Zhou JP, Brown J, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 1998;282:1497-1501.
19. Díaz C, Quesada S, Brenes O, Aguilar G, Ciccio J. Chemical composition of Schinus molle essential oil and its cytotoxic activity on tumour cell lines. Nat Prod Res. 2008;22:521-534.
20. Shi L, Chen J, Wang YY, Sun G, Lin JN, Zhang JX, et al. Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. Cell Mol Neurobiol. 2012;32:289-296.
21. Hermekin H, Benzinger A. 14-3-3 proteins in cell cycle regulation. Semin Cancer Biol. 2006;16:183-192.
22. Takeba Y, Kumai T, Matsumoto N, Nakaya S, Tsuzuki Y, Yanagida Y, et al. Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis. J Pharmacol Sci. 2007;3:232-242.
23. Aydin E, Türkez H, Geyikoglu F. Antioxidative, anticancer and genotoxic properties of a-pinene on N2a neuroblastoma cells. Biologia. 2013;68:1004-1009.