Inhibitory effects of α-pinene on hepatoma carcinoma cell proliferation

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 7, 2014, Pages 3293-3297

  Chen, Wei Qiang ^a   Xu, Bin ^a   Mao, Jian Wen ^a   Wei, Feng Xiang ^b   Li, Ming ^a   Liu, Tao ^a   Jin, Xiao Bao ^a   Zhang, Li Rong ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b Shenzhen Key Laboratory for Birth Defects Prevention and Control   (China)

Author keywords

Cell cycle proteins; Hepatoma carcinoma; Proliferation; pinene

Indexed keywords

ALPHA-PINENE; ANTINEOPLASTIC AGENT; CDC25C PROTEIN, HUMAN; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; MESSENGER RNA; PLANT EXTRACT; PROTEIN TYROSINE PHOSPHATASE; TERPENE;

APOPTOSIS; BIOSYNTHESIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFECTS; GENETICS; HUMAN; LIVER NEOPLASMS; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; PINE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; DOWN-REGULATION; HUMANS; LIVER NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; MONOTERPENES; PINUS; PLANT EXTRACTS; RNA, MESSENGER;

EID: 84900866612     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.7.3293     Document Type: Article

References (18)

1. Bassermann F, von Klitzing C, Illert AL, et al (2007). Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1. J Biol Chem, 282, 15965-72.
2. Bhattacharjee B, Chatterjee J (2013). Dentification of proapotopic, J anti-inflammatory, anti-proliferative, antiinvasive and anti-angiogenic targets of essential oils incardamom by dual reverse virtual screening and binding pose analysis. Asian Pac J Cancer Prev, 14, 3735-42
3. Catanzaro I, Caradonna F, Barbata G, et al (2012) Genomic instability induced by alpha-pinene in Chinese hamster cell line. Mutagenesis, 27, 463-9.
4. Drouet M, Herodin F, Norol F, Ḿourcin F, Mayol JF (2001). Cell cycle activation of peripheral blood stem and progenitor cells expanded ex vivo with SCF, FLT-D3 ligand, TPO, and IL-3 results in accelerated granulocyte recovery in a baboon model of autologous transplantation but G0/G1 and S/G2/M graft cell content does not correlate with transplantability. Stem Cells, 19, 436-442
5. Jeong SI, Lim JP, Jeon H (2007) Chemical composition and antibacterial activities of the essential oil from Abies koreana. Phytother Res, 21, 1246-50.
6. Kim K, Chun KH, Suh PG, Kim IH (2011). Alterations in cell proliferation related gene expressions in gastric cancer. Crit Rev Eukaryot Gene Expr, 21, 237-54.
7. Kusuhara M, Urakami K, Masuda Y, et al (2012). Fragrant environment with alpha-pinene decreases tumor growth in mice. Biomed Res, 33, 57-61.
8. Lau WS, Chen T, Wong YS (2010). Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C. Mol Med Rep, 3, 1023-30.
9. Le Gac G, Esteve PO, Ferec C, Pradhan S (2006). DNA damageinduced down-regulation of human Cdc25C and Cdc2 is mediated by cooperation between p53 and maintenance DNA (cytosine-5) methyltransferase 1. J Biol Chem, 281, 24161-70.
10. Loizzo MR, Menichini F, Tundis R, et al (2010). Comparative chemical composition and antiproliferative activity of aerial parts of Salvia leriifolia Benth. and Salvia acetabulosa L. essential oils against human tumor cell in vitro models. J Med Food, 13, 62-9.
11. Matsuo AL, Figueiredo CR, Arruda DC, et al (2011). Alpha-pinene isolated from schinus terebinthifolius raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model. Biochem Biophys Res Commun, 411, 449-54.
12. Meng LY, Liu HR, Shen Y, et al (2011). Cochinchina momordica seed extract induces G2/M arrest and apoptosis in human breast cancer MDA-MB-231 cells bymodulating the PI3K/Akt pathway. Asian Pac J Cancer Prev, 12, 3483-8.
13. Pichette A, Larouche PL, Lebrun M, Legault J (2006). Composition and antibacterial activity of Abies balsamea essential oil. Phytother Res, 20, 371-3.
14. Ruiz EJ, Vilar M, Nebreda AR (2010). A two-step inactivation mechanism of Myt1 ensures CDK1/cyclin B activation and meiosis I entry. Curr Biol, 20, 717-23.
15. Russo AJ, Magro PG, Hu Z, et al (2006). E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. Cancer Res, 66, 7253-60.
16. Singh HP, Batish DR, Kaur S, Arora K, Kohli RK (2006). alpha- Pinene inhibits growth and induces oxidative stress in roots. Ann Bot, 98, 1261-9.
17. Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I(2010). Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. J Biol Chem, 285, 16978-90.
18. Wajs A, Urbanska J, Zaleskiewicz E, Bonikowski R (2010). Composition of essential oil from seeds and cones of Abies alba. Nat Prod Commun, 5, 1291-4.