Escin Increases the Survival Rate of LPS-Induced Septic Mice Through Inhibition of HMGB1 Release from Macrophages

Cellular Physiology and Biochemistry

Volumn 36, Issue 4, 2015, Pages 1577-1586

  Cheng, Yajun ^a   Wang, Hongrui ^b   Mao, Min ^b   Liang, Chao ^b   Zhang, Yu ^b   Yang, Deijun ^b   Wei, Ziran ^b   Gao, Shunxiang ^c   Hu, Bo ^c   Wang, Lianghua ^c   Cai, Qingping ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Escin; High motility group box 1(HMGB1); NF B; Sepsis

Indexed keywords

ESCIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; CYTOKINE; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; ENDOTOXEMIA; IMMUNOLOGY; SEPSIS;

ANIMALIA; MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYTOKINES; ENDOTOXEMIA; ESCIN; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; SEPSIS; SURVIVAL RATE;

EID: 84936933436     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430320     Document Type: Article

References (23)

1. Liesenfeld O, Lehman L, Hunfeld KP, Kost G: Molecular diagnosis of sepsis: New aspects and recent developments. Eur J MicrobiolImmunol (Bp) 2014;4:1-25.
2. Lotze MT, Tracey KJ: High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005;5:331-342.
3. Huang W, Tang Y, Li L: HMGB1, a potent proinflammatory cytokine in sepsis Cytokine 2010;51:119-126.
4. Yang Y, Li S, Yang Q, Shi Y, Zheng M, Liu Y, Chen F, Song G, Xu H, Wan T, He J, Chen Z: Resveratrol reduces the proinflammatory effects and lipopolysaccharide-induced expression of HMGB1 and TLR4 in RAW264. 7 cells. Cell Physiol Biochem 2014;33:1283-1292.
5. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A,Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, AnderssonJ,Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ: HMGB-1 as a late mediator of endotoxin lethality in mice. Science 1999;285:248-251.
6. Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, Susarla SM, Ulloa L, Wang H, DiRaimo R, Czura CJ, Wang H, Roth J, Warren HS, Fink MP, Fenton MJ, Andersson U, Tracey KJ: Reversing established sepsis with antagonists of endogenous high-mobility group box 1. ProcNatlAcadSci U S A 2004;101:296-301.
7. Sirtori CR: A Escin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res 2001;44:183-193.
8. Xin W, Zhang L, Fan H, Jiang N, Wang T, Fu F: Escin attenuates acute lung injury induced by endotoxin in mice. Eur J Pharm Sci 2011;42:73-80.
9. Jiang N, Xin W, Wang T, Zhang L, Fan H, Du Y, Li C, Fu F: Protective effect of Escin from the seeds of Aesculushippocastanum on liver injury induced by endotoxin in mice. Phytomedicine 2011;18:1276-1284.
10. Zhang Z, Zhang L, Zhou C, Wu H: Ketamine inhibits LPS-induced HGMB1 release in vitro and in vivo. IntImmunopharmacol 2014;23:14-26.
11. Liu T, He YW: Protective effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure. ZhonghuaGanZang Bing ZaZhi 2010;18:222-226.
12. Li Y, Gan CP, Zhang S, Zhou XK, Li XF, Wei YQ, Yang JL, Wu M: FIP200 is involved in murine pseudomonas infection by regulating HMGB1 intracellular translocation. Cell Physiol Biochem 2014;33:1733-1744.
13. Huston JM, Wang H, Ochani M, Ochani K, Rosas-Ballina M, Gallowitsch-Puerta M, Ashok M, Yang L, Tracey KJ, Yang H: Splenectomy protects against sepsis lethalityand reduces serum HMGB1 levels. J Immunol 2008;181:3535-3539.
14. O'Riordain MG, O'Riordain DS, Molloy RG, Mannick JA, Rodrick ML: Dosage and timing of anti-TNF-alpha antibody treatment determine its effect of resistance to sepsis after injury. J Surg Res 1996;64:95-101.
15. Wu ZS, Yao YM, Hong GL, Xu XP, Liu Y, Dong N, Zheng JY, Lu ZQ, Zhao GJ, Zhu XM, Zhang QH, Sheng ZY: Role of mitofusin-2 in high mobility group box-1 protein-mediated apoptosis of T cells in vitro. Cell Physiol Biochem 2014;33:769-783.
16. Kanczkowski W, Chatzigeorgiou A, Samus M, Tran N, Zacharowski K, ChavakisT, Bornstein SR: Characterization of the LPS-induced inflammation of the adrenal gland in mice. Mol Cell Endocrinol 2013;371:228-235.
17. Huang W, Tang Y, Li L: HMGB1, a potent proinflammatory cytokine in sepsis. Cytokine 2010;51:119-126.
18. Gámez-Díaz LY, Enriquez LE, Matute JD, Velásquez S, Gómez ID, Toro F, OspinaS, Bedoya V, Arango CM, Valencia ML, De La Rosa G, Gómez CI, García A, PatiñoPJ,Jaimes FA: Diagnostic accuracy of HMGB-1, sTREM-1, and CD64 as markers of sepsis in patients recently admitted to the emergency department. AcadEmerg Med 2011;18:807-815.
19. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A,Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J,Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ: HMG-1 as a late mediator of endotoxinlethality in mice. Science 1999;285: 248-251.
20. Sama AE, D'Amore J, Ward MF, Chen G, Wang H: Bench to bedside: HMGB1 - A novel proinflammatory cytokine and potential therapeutic target for septic patients in the emergency department. AcadEmerg Med 2004;11: 867-873.
21. Harris HE, Raucci A: Alarmin (g) news about danger. EMBO Reports 2006;7:774-778.
22. Jiang W, Pisetsky DS: The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW264. 7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide. J Immunol 2006;177: 3337-3343.
23. Bonaldi T, Talamo F, Scaffidi P, Ferrera D, Porto A, Bachi A, Rubartelli A, Agresti A, Bianchi ME: Monocytic cells hyperacetylate chromatin protein HMGB1to redirect it towards secretion. EMBO J 2003;22: 5551-5560.