Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models

Journal of Pharmacological Sciences

Volumn 127, Issue 3, 2015, Pages 237-243

  So, Kanako ^a   Haraguchi, Kayo ^a   Asakura, Kayoko ^a   Isami, Koichi ^a   Sakimoto, Shinya ^a   Shirakawa, Hisashi ^a   Mori, Yasuo ^a   Nakagawa, Takayuki ^a,b   Kaneko, Shuji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Inflammatory pain; Knockout mice; Neuropathic pain; Pain models; TRPM2

Indexed keywords

CAPSAICIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PACLITAXEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRALGIA; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIABETIC NEUROPATHY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENOTYPE; INFLAMMATORY PAIN; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; OSTEOARTHRITIS; PERIPHERAL NEUROPATHY; POSTOPERATIVE PAIN; PROTEIN ANALYSIS; PROTEIN FUNCTION; WRITHING TEST; ANIMAL; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; NEURALGIA; PHYSIOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURALGIA; TRPM CATION CHANNELS;

EID: 84936879363     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2014.10.003     Document Type: Article

References (54)

1. Calvo M, Dawes JM, Bennett DL. The role of the immune system in the generation of neuropathic pain. Lancet Neurol. 2012;11:629-642.
2. Ren K, Dubner R. Interactions between the immune and nervous systems in pain. Nat Med. 2010;16:1267-1276.
3. Gao YJ, Ji RR. Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther. 2010;126:56-68.
4. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, et al. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature. 2001;411:595-599.
5. 2+ influx system mediated by LTRPC2. Science. 2001;293:1327-1330.
6. Miyake T, Shirakawa H, Kusano A, Sakimoto S, Konno M, Nakagawa T, et al. TRPM2 contributes to LPS/IFNg-induced production of nitric oxide via the p38/JNK pathway in microglia. Biochem Biophys Res Commun. 2014;444:212-217.
7. 2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002;9:163-173.
8. Buelow B, Song Y, Scharenberg AM. The poly (ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem. 2008;283:24571-24583.
9. Takahashi N, Kozai D, Kobayashi R, Ebert M, Mori Y. Roles of TRPM2 in oxidative stress. Cell Calcium. 2011;50:279-287.
10. Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, et al. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun. 2013;4:1611.
11. Knowles H, Li Y, Perraud AL. The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation. Immunol Res. 2013;55:241-248.
12. 2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med. 2008;14:738-747.
13. Wehrhahn J, Kraft R, Harteneck C, Hauschildt S. Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes. J Immunol. 2010;184:2386-2393.
14. Kashio M, Sokabe T, Shintaku K, Uematsu T, Fukuta N, Kobayashi N, et al. Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. Proc Natl Acad Sci U S A. 2012;109:6745-6750.
15. Haraguchi K, Kawamoto A, Isami K, Maeda S, Kusano A, Asakura K, et al. TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci. 2012;32:3931-3941.
16. Isami K, Haraguchi K, So K, Asakura K, Shirakawa H, Mori Y, et al. Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model. PLoS One. 2013;8:e66410.
17. Barrot M. Tests and models of nociception and pain in rodents. Neuroscience. 2012;211:39-50.
18. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55-63.
19. Callahan BL, Gil AS, Levesque A, Mogil JS. Modulation of mechanical and thermal nociceptive sensitivity in the laboratory mouse by behavioral state. J Pain. 2008;9:174-184.
20. Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol. 1980;20:441-462.
21. Sakurada T, Katsumata K, Tan-No K, Sakurada S, Kisara K. The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord. Neuropharmacology. 1992;31:1279-1285.
22. Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008;28:2485-2494.
23. Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain. 1996;64:493-501.
24. Pogatzki EM, Raja SN. A mouse model of incisional pain. Anesthesiology. 2003;99:1023-1027.
25. Harvey VL, Dickenson AH. Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice. Mol Pain. 2009;5:18.
26. Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T, et al. Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010;107:12233-12238.
27. Ito S, Tajima K, Nogawa M, Inoue N, Kyoi T, Takahashi Y, et al. Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. J Pharmacol Exp Ther. 2012;342:53-60.
28. Loeser JD, Treede RD. The Kyoto protocol of IASP basic pain terminology. Pain. 2008;137:473-477.
29. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. 2001;413:203-210.
30. Keeble JE, Bodkin JV, Liang L, Wodarski R, Davies M, Fernandes ES, et al. Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms. Pain. 2009;141:135-142.
31. Naziroglu M, Ozgül C, Çelik O, Çig B, Sozbir E. Aminoethoxydiphenyl borate and flufenamic acid inhibit Ca2+ influx through TRPM2 channels in rat dorsal root ganglion neurons activated by ADP-ribose and rotenone. J Membr Biol. 2011;241:69-75.
32. Lewis ND, Muthukumarana A, Fogal SE, Corradini L, Stefanopoulos DE, Adusumalli P, et al. CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells. PloS One. 2014;9:e105883.
33. Brennan TJ, Zahn PK, Pogatzki-Zahn EM. Mechanisms of incisional pain. Anesthesiol Clin North America. 2005;23:1-20.
34. Fujita I, Okumura T, Sakakibara A, Kita Y. Involvement of inflammation in severe post-operative pain demonstrated by pre-surgical and post-surgical treatment with piroxicam and ketorolac J Pharm Pharmacol. 2012;64:747-755.
35. Romero-Sandoval A, Chai N, Nutile-McMenemy N, Deleo JA. A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res. 2008;1219:116-126.
36. Wen YR, Suter MR, Ji RR, Yeh GC, Wu YS, Wang KC, et al. Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incisioninduced mechanical allodynia. Anesthesiology. 2009;110:155-165.
37. Xu J, Brennan TJ. Guarding pain and spontaneous activity of nociceptors after skin versus skin plus deep tissue incision. Anesthesiology. 2010;112:153-164.
38. Goldring MB, Goldring SR. Osteoarthritis. J Cell Physiol. 2007;213:626-634.
39. Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci USA. 2012;109:20602-20607.
40. Sagar DR, Burston JJ, Hathway GJ, Woodhams SG, Pearson RG, Bennett AJ, et al. The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain. Mol Pain. 2011;7:88.
41. Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol. 2005;23:683-747.
42. Melzer N, Hicking G, Gobel K, Wiendl H. TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. PloS One. 2012;7:e47617.
43. Olechowski CJ, Truong JJ, Kerr BJ. Neuropathic pain behaviours in a chronicrelapsing model of experimental autoimmune encephalomyelitis (EAE). Pain. 2009;141:156-164.
44. Cao L, DeLeo JA. CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. Eur J Immunol. 2008;38:448-458.
45. Costigan M, Moss A, Latremoliere A, Johnston C, Verma-Gandhu M, Herbert TA, et al. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. 2009;29:14415-14422.
46. Flatters SJ, Bennett GJ. Studies of peripheral sensory nerves in paclitaxelinduced painful peripheral neuropathy: evidence for mitochondrial dysfunction. Pain. 2006;122:245-257.
47. Jaggi AS, Singh N. Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology. 2012;291:1-9.
48. Ruiz-Medina J, Baulies A, Bura SA, Valverde O. Paclitaxel-induced neuropathic pain is age dependent and devolves on glial response. Eur J Pain. 2013;17:75-85.
49. Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R. TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal. 2009;2:ra23.
50. Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, et al. Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes. 2011;60:119-126.
51. Zhang Z, Zhang W, Jung DY, Ko HJ, Lee Y, Friedline RH, et al. TRPM2 Ca2+ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012;302:E807-E816.
52. Vincent AM, Callaghan BC, Smith AL, Feldman EL. Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nat Rev Neurol. 2011;7:573-583.
53. Zhou J, Zhou S. Inflammation: therapeutic targets for diabetic neuropathy. Mol Neurobiol. 2014;49:536-546.
54. Tsuda M, Ueno H, Kataoka A, Tozaki-Saitoh H, Inoue K. Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling. Glia. 2008;56:378-386.