Glycerol monolaurate microbicide protection against repeat high-dose SIV vaginal challenge

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Haase, Ashley T ^a   Rakasz, Eva ^b   Schultz Darken, Nancy ^b   Nephew, Karla ^b   Weisgrau, Kimberly L ^b   Reilly, Cavan S ^c   Li, Qingsheng ^a,e   Southern, Peter J ^a   Rothenberger, Meghan ^a   Peterson, Marnie L ^d   Schlievert, Patrick M ^a,f  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF NEBRASKA   (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL MONOLAURATE; MICROBICIDE; PLACEBO; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIRETROVIRUS AGENT; LAURIC ACID DERIVATIVE; MONOACYLGLYCEROL; MONOLAURIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; INFECTION PREVENTION; NONHUMAN; PILOT STUDY; RHESUS MONKEY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS TRANSMISSION; ANIMAL; DRUG EFFECTS; HIV INFECTIONS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MUCOSA; SOUTH AFRICA; VAGINA; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-RETROVIRAL AGENTS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LAURATES; MACACA MULATTA; MONOGLYCERIDES; MUCOUS MEMBRANE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; SOUTH AFRICA; VAGINA;

EID: 84936857131     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129465     Document Type: Article

References (27)

1. Fauci AS (2008) 25 years of HIV. Nature 453: 289-290 doi: 10.1038/453289a PMID: 18480799
2. Abdool Karim Q, Abdool Karim SS, Singh B, Ngxongo S (1992) Seroprevalence of HIV infection in rural South Africa. AIDS 6: 1535-1539 PMID: 1492937
3. Quinn TC, Overbaugh J (2005) HIV/AIDS in women: an expanding epidemic. Science 308: 1582-1583 PMID: 15947174
4. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. (2010) Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. New Engl J Med 363: 2587-2599 doi: 10.1056/NEJMoa1011205 PMID: 21091279
5. Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. (2010) Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for prevention of HIV infection in women. Science 329: 1168-1174 doi: 10.1126/science.1193748 PMID: 20643915
6. Anonymous. MTN-003 - VOICE (2012) http://www.mtnstopshiv.org/news/studies/mtn003
7. Abdool Karim SS, Kashuba A, Werner L, Abdool Karim Q (2011) Drug concentrations following topical and oral antiretroviral pre-exposure prophylaxis: Implications for HIV prevention in women. Lancet 378: 279-281 doi: 10.1016/S0140-6736(11)60878-7 PMID: 21763939
8. Naranbhai V, Abdool Karim SS, Altfeld M, Samsunder N, Durgiah R, Sibeko S, et al. (2012) Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis 206: 993-1001 PMID: 22829639
9. Glavin SR Cohen MS (2004) The role of sexually transmitted diseases in HIV transmission. Nature Rev Microbiol 2: 33-42 PMID: 15035007
10. Kaul R, Pettengell C, Sheth PM, Sunderji S, Biringer A, MacDonald K, et al. (2008) The genital tract immune milieu: an important determinant of HIV susceptibility and secondary transmission. J Reprod Immunol 77: 32-40 PMID: 17395270
11. Peterson M, Schlievert P (2006) Glycerol monolaurate inhibits the effects of gram-positive select agents on eukaryotic cells. Biochemistry 245: 2387-2397
12. Witcher K, Novick R. Schlievert P (1996) Modulation of immune cell proliferation by glycerol monolaurate. Clin Diagn Lab Immunol 3: 10-13 PMID: 8770497
13. Projan S, Brown-Skrobot S, Schlievert PM, Vandenesch F, Novick RP (1994) Glycerol monolaurate inhibits the production of beta-lactamase toxic shock toxin-1 and other staphylocococcal exoprotein by interfering with signal transduction J Bacteriol 176: 4204-4209 PMID: 8021206
14. Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, Southern PJ, et al. (2009) Glycerol monolaurate prevents mucosal SIV transmission. Nature 458: 1034-1038. doi: 10.1038/nature07831 PMID: 19262509
15. Schlievert PM, Strandberg KL, Brosnahan AJ, Peterson ML, Pambuccian SE, Nephew KR, et al. (2008) Glycerol monolaurate does not alter rhesus macaque (Macacca mulatta) vaginal lactobacilli and is safe for chronic use. Antimicrob Agents Chemother 52: 4448-4454 doi: 10.1128/AAC.00989-08 PMID: 18838587
16. Baeten JM, Kahle E, Lingappa JR, Coombs RW, Delany-Moretlwe S, Nakku-Joloba E, et al. (2011) Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission. Sci Transl Med 3: 77ra29 doi: 10.1126/scitranslmed.3001888 PMID: 21471433
17. McChesney MB, Collins JR, Lu D, Lu X, Torten J, Ashley RL, et al. (1998) Occult systemic infection and persistent SIV-specific CD4+ T cell proliferative responses in rhesus macaques that were transiently viremic after intravaginal inoculation of SIV. J Virol 72: 10029-10035 PMID: 9811741
18. Ma Z-M, Abel K, Rourke T, Wang Y, Miller C (2004) A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low dose intra-vaginal Simian Immuno Deficiency Virus inoculations. J Virol 78: 14048-14052 PMID: 15564513
19. Miller CJ, Li Q, Abel K, Kim E-Y, Ma Z-M, Wietgrefe S, et al. (2005) Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus. J Virol 79: 9217-9227 PMID: 15994816
20. Cline AN, Bess JW, Piatek M Jr, Lifson JD (2005) Highly sensitive plasma viral load assay:practical considerations, realitic performance expectations and application to reverse engineering of vaccines for AIDS. J Med Primatol 34: 303-312 PMID: 16128925
21. Friedrich TC, Dodds EJ, Yant LJ, Vojnov L, Rudersdorf R, Cullen C, et al. (2004) Reversion of cytotoxic T-lymphocyte (CTL) escape variant viruses in vivo. Nat Med 10: 275-281 PMID: 14966520
22. Wilson NA, Reed J, Napoe GS, Piaskowski S, Szymanski A, Furlott J, et al. (2006) Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. J Virol 80: 5875-5885 PMID: 16731926
23. Marthas ML, Lu D, Penedo MC, Hendrickx AG, Miller CJ (2001) Titration of an SIVmac251 stock by vaginal inoculation of Indian and Chinese origin rhesus macaques: transmission efficiency, viral loads, and antibody responses. AIDS Res Hum Retrovir 17: 1455-1466. PMID: 11679158
24. Haase AT (2010) Targeting early infection to prevent HIV-1 mucosal transmission. Nature 464: 217-223 doi: 10.1038/nature08757 PMID: 20220840
25. Urdaneta S, Neely EB, Stiller C, Berlin CM, Wigdahl B, Isaacs CE, et al. (2005) Antiviral activity of alkyl sulfates and the synthetic derivate octylglycerol in human milk for prevention of transmission of HIV-1. 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment. Rio de Janeiro (2005)
26. Jones A, Cremin I, Abdullah F, Idoko J, Cherutich P, Kilonzo N, et al. (2014) Transformation of HIV from pandemic to low-endemic levels: a public health approach to combination prevention. Lancet 384: 272-279 doi: 10.1016/S0140-6736(13)62230-8 PMID: 24740087
27. Dobard C, Sharma S, Parikh UM, West R, Taylor A, Martin A, et al. (2014) Post exposure protection of macaques from vaginal SHIV Infection by topical integrase inhibitors. Sci Transl Med 6: 227ra35 doi: 10.1126/scitranslmed.3007701 PMID: 24622515