Regression based quasi-experimental approach when randomisation is not an option: Interrupted time series analysis

BMJ (Online)

Volumn 350, Issue , 2015, Pages

  Kontopantelis, Evangelos ^a,b   Doran, Tim ^c   Springate, David A ^a,b   Buchan, Iain ^a   Reeves, David ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED APPROACH; ARTICLE; BASIC APPROACH; DATA ANALYSIS; DATA PROCESSING; EPIDEMIOLOGICAL DATA; EXPERT APPROACH; LONGITUDINAL STUDY; PRIORITY JOURNAL; QUASI EXPERIMENTAL STUDY; RANDOMIZATION; TIME SERIES ANALYSIS; TREND STUDY; EPIDEMIOLOGY; METHODOLOGY; STATISTICS AND NUMERICAL DATA;

INTERRUPTED TIME SERIES ANALYSIS; RESEARCH DESIGN;

EID: 84936850589     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.h2750     Document Type: Article

References (15)

1. Saunders C, Byrne CD, Guthrie B, et al. External validity of randomized controlled trials of glycaemic control and vascular disease: how representative are participants? Diabetic Med 2013;30:300-8.
2. Guthrie B, Payne K, Alderson P, et al. Adapting clinical guidelines to take account of multimorbidity. BMJ 2012;345:e6341.
3. Wagner AK, Soumerai SB, Zhang F, et al. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther 2002;27:299-309.
4. O'Keeffe AG, Geneletti S, Baio G, et al. Regression discontinuity designs: an approach to the evaluation of treatment efficacy in primary care using observational data. BMJ 2014;349:g5293.
5. Campbell SM, Reeves D, Kontopantelis E, et al. Effects of pay for performance on the quality of primary care in England. N Engl J Med 2009;361:368-78.
6. Rabe-Hesketh S, Skrondal A. Multilevel and longitudinal modeling using Stata. 3rd ed. Stata Press, 2012.
7. Efron B. The bootstrap and modern statistics. J Am Stat Assoc 2000;95:1293-6.
8. Kontopantelis E, Reeves D, Valderas JM, et al. Recorded quality of primary care for patients with diabetes in England before and after the introduction of a financial incentive scheme: a longitudinal observational study. BMJ Qual Saf 2013;22:53-64.
9. Doran T, Kontopantelis E, Valderas JM, et al. Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ 2011;342:d3590.
10. Kontopantelis E, Springate D, Reeves D, et al. Withdrawing performance indicators: retrospective analysis of general practice performance under UK Quality and Outcomes Framework. BMJ 2014;348:g330.
11. Kontopantelis E, Springate DA, Reeves D. A re-analysis of the Cochrane Library data: the dangers of unobserved heterogeneity in meta-analyses. Plos One 2013;8:e69930.
12. Silverman SL. From randomized controlled trials to observational studies. Am J Med 2009;122:114-20.
13. Grijalva CG, Nuorti JP, Arbogast PG, et al. Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet 2007;369:1179-86.
14. Grundy C, Steinbach R, Edwards P, et al. Effect of 20 mph traffic speed zones on road injuries in London, 1986-2006: controlled interrupted time series analysis. BMJ 2009;339:b4469.
15. Mahamat A, MacKenzie FM, Brooker K, Monnet DL, Daures JP, Gould IM. Impact of infection control interventions and antibiotic use on hospital MRSA: a multivariate interrupted time-series analysis. Int J Antimicrob Agents 2007;30:169-76.