Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages 8445-8450

  Corbett, Grant T ^a,b   Gonzalez, Frank J ^c   Pahan, Kalipada ^b,d  

^a RUSH MEDICAL COLLEGE   (United States)

^b RUSH UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

ADAM10; Alzheimer's disease; APP; Pparalpha

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; GEMFIBROZIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PRESENILIN 1; RETINOID X RECEPTOR ALPHA; ADAM PROTEIN; ADAM10 PROTEIN, MOUSE; MEMBRANE PROTEIN; PIRINIXIC ACID; PYRIMIDINE DERIVATIVE; SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; FRONTAL CORTEX; GENE OVEREXPRESSION; GENE SILENCING; HIPPOCAMPUS; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; AGONISTS; ALZHEIMER DISEASE; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOBLOTTING; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; MALE; METABOLISM; NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

MUS;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CELLS, CULTURED; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; KAPLAN-MEIER ESTIMATE; MALE; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; NEURONS; PPAR ALPHA; PROTEOLYSIS; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84936817463     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1504890112     Document Type: Article

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