Stability, intracellular delivery, and release of siRNA from chitosan nanoparticles using different cross-linkers

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Raja, Maria Abdul Ghafoor ^a   Katas, Haliza ^a   Wen, Thum Jing ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

CHITOSAN NANOPARTICLE; DEXTRAN SULFATE; POLY DEXTRO GLUTAMIC ACID; POLYGLUTAMINE; SMALL INTERFERING RNA; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG; CHITOSAN; CHITOSAN SULFATE; DRUG CARRIER; GEL; NANOPARTICLE; POLYGLUTAMIC ACID; POLYPHOSPHATE; TRIPHOSPHORIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BIOASSAY; BIOCOMPATIBILITY; BURST RELEASE; CELL VIABILITY; CHEMICAL PROCEDURES; COLORECTAL CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DRUG BINDING; DRUG CYTOTOXICITY; DRUG DOSAGE FORM COMPARISON; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; DRUG TRANSPORT; ENTRAPMENT EFFICIENCY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; IONIC GELATION; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; SERUM PROTECTION ASSAY; STORAGE TEMPERATURE; STRUCTURE ANALYSIS; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GEL; METABOLISM; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; CHITOSAN; DEXTRAN SULFATE; DRUG CARRIERS; GELS; HUMANS; NANOPARTICLES; PARTICLE SIZE; POLYGLUTAMIC ACID; POLYPHOSPHATES; RNA, SMALL INTERFERING;

EID: 84936804818     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128963     Document Type: Article

References (40)

1. Akhtar S, Benter IF. Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest. 2007; 117:3623-32. PMID: 18060020
2. De Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov. 2007; 6:443-53. PMID: 17541417
3. Kirchhoff F. Silencing HIV-1 in vivo. Cell. 2008; 34:566-8.
4. Shim MS, Kwon YJ. Efficient and targeted delivery of siRNA in vivo. FEBS J. 2010; 277:4814-27. doi: 10.1111/j.1742-4658.2010.07904.x PMID: 21078116
5. Piao L, Li H, Teng L, Yung BC, Sugmito Y, Brueggemeier RW, et al. Human serum albumin-coated lipid nanoparticles for delivery of siRNA to breast cancer. Nanomed-Nanotechnol. 2013; 9:122-129.
6. Lundstrom K. Latest development in viral vectors for genetherapy. Trends Biotechnol. 2003; 21:117-122. PMID: 12628368
7. Li SD, Huang L. Non-viral is superior to viral gene delivery. J Control Release. 2007; 123:181-183. PMID: 17935817
8. Kim SH, Mok H, Jeong JH, Kim SW, Park TG. Comparative evaluation of target specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate. Bioconjugate Chem. 2006; 17:241-244. PMID: 16417275
9. Kleemann E, Neu M, Jekel N, Fink L, Schmehl T, Gessler T, et al. Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J Control Release. 2005; 109:299-316. PMID: 16298009
10. Felgner JH, Kumar R, Sridhar CN, Wheeler CJ, Tsai YJ, Border R, et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem. 1994; 269:2550-2561. PMID: 8300583
11. Liu F, Huang L. Development of non-viral vectors for systemic gene delivery. J Control Release. 2002; 78:259-266. PMID: 11772466
12. Dash M, Chiellini F, Ottenbrite RM. Chiellni E. Chitosan - A versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci. 2011; 36:981-1014.
13. Hamidi M, Azadi A, Rafiei P. Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev. 2008; 60:1638-1649. doi: 10.1016/j.addr.2008.08.002 PMID: 18840488
14. Liu Z, Jiao Y, Wang Y, Zhou C, Zhang Z. Polysaccharides-based nanoparticles as drug delivery systems. Adv Drug Deliv Rev. 2008; 60:1650-1662. doi: 10.1016/j.addr.2008.09.001 PMID: 18848591
15. Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm. Res. 1998; 15:1326-1331. PMID: 9755881
16. Malmo J, Vårum KM, Strand SP. Effect of chitosan chain architecture on gene delivery: comparison of self-branched and linear chitosans. Biomacromolecules. 2011; 12:721-729. doi: 10.1021/bm1013525 PMID: 21294570
17. Strand SP, Issa MM, Christensen BE, Varum KM, Artursson P. Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties. Biomacromolecules. 2008; 9:3268-76. doi: 10.1021/bm800832u PMID: 18834173
18. Germershaus O, Mao S, Sitterberg J, Bakowsky U, Kissel T. Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro. J Control Release. 2008; 125:145-154. PMID: 18023906
19. Baldrick P. The safety of chitosan as a pharmaceutical excipient. Regul Toxicol Pharmacol. 2010; 56:290-299. doi: 10.1016/j.yrtph.2009.09.015 PMID: 19788905
20. Ko JA, Park HJ, Hwang SJ, Park JB, Lee JS. Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm. 2002; 249:165-174. PMID: 12433445
21. Avadi MR, Sadeghi AM, Mohammadpour N, Abedin S, Atyabi F, Dinavand R, et al. Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method. Nanomed-Nanotechnol. 2010; 6:58-63.
22. Anitha A, Deepagan VG, Rani VVD, Menon D, Nair SV, Jayakumar R. Preparation,characterisation, in vitro drug release and biological studies of curcumin loaded dextransulphate-chitosan nanoparticles. Carbohyd Polym. 2011; 84:1158-64.
23. Tsao CT, Chang CH, Lin YY, Wu MF, Wang JL, Young TH, et al. Evaluation of chitosan/γ-ply(glutamic acid) polyelectrolyte complex for wound dressing materials.Carbohyd Polym. 2011; 84:812-819.
24. Lin YH, Chung CK, Chen CT, Liang HF, Chen SC, Sung HW. Preparation of nanoparticles composed of chitosan/ poly-gamma-glutamic acid and evaluation of their permeability through caco2 cells. Biomacromolecules. 2005; 6:1104-12. PMID: 15762683
25. Papadimitriou AS, Achilias DA, Bikiaris DN. Chitosan-g-PEG nanoparticles ionically crosslinked with poly(glutamic acid) and tripolyphosphate as protein delivery systems. Int J Pharm. 2012; 430:318-327. doi: 10.1016/j.ijpharm.2012.04.004 PMID: 22521711
26. Calvo P, López CR, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosan- polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci. 1997; 63:125-132.
27. Fan W, Yan W, Xu Z, Ni H. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids Surf B. 2012; 90:21-27. doi: 10.1016/j.colsurfb.2011.09.042 PMID: 22014934
28. Katas H, Alpar HO. Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release. 2006; 115:216-225. PMID: 16959358
29. Rampino A, Borgogna M, Blasi P, Bellich B, Cesaro A. Chitosan nanoparticles: Preparation, size evolution and stability. Int J Pharm. 2013; 455:219-228. doi: 10.1016/j.ijpharm.2013.07.034 PMID: 23886649
30. Csaba N, Koping-Hoggard M, Alonso MJ. Ionically crosslinked chitosan/ tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery. Int J Pharm. 2009; 382:205-214. doi: 10.1016/j.ijpharm.2009.07.028 PMID: 19660537
31. Vanderberg GW, Drolet C, Scott SL, de la Noue J. Factors affecting protein release from Alginate chitosan coacervate microcapsules during production and gastro/intestinal simulation. J Control Release. 2001; 77:297-307. PMID: 11733097
32. Hickerson RP, Vlassov AV, Wang Q, Leake D, Ilves D, Gonzalez-Gonzalez E, et al.Stability study of unmodified siRNA and relevance to clinical use. Oligonucleotides.2008; 18:345-354. doi: 10.1089/oli.2008.0149 PMID: 18844576
33. Rodrigues S, Costa AMR, Grenha A. Chitosan/ carrageenan nanoparticles:effect of Cross linking with tripolyphosphate and charge ratios. Carbohyd Polym. 2012; 89:282-289 doi: 10.1016/j.carbpol.2012.03.010 PMID: 24750635
34. Raja MAG, Katas H, Hamid ZA, Razali NA. Physicochemical properties and in vitro cytotoxicity studies of chitosan as a potential carrier for Dicer-substrate siRNA. J Nanomater. 2013;doi: 10.1155/2013/653892
35. Al-Qadi S, Grenha A, Remuñán-López C. Microspheres loaded with polysaccharide nanoparticles for pulmonary delivery: Preparation, structure and surface analysis Carbohyd Polym. 2011; 86: 25-34.
36. Tsai ML, Chen RH, Bai SW, Chen WY. The storage stability of chitosan/tripolyphosphate nanoparticles in a phosphate buffer. Carbohyd Polym. 2011; 84:756-761.
37. Dudhani AR, Kosaraju SL. Bioadhesive chitosan nanoparticles: Preparation And characterization. Carbohyd Polym. 2010; 81:243-251.
38. Hu W, Peng C, Lv M, Li X, Zhang Y, Chen N, et al. Protein corona-mediated mitigation of cytotoxicity of graphene oxide. ACS NANO. 2011; 5:3693-3700. doi: 10.1021/nn200021j PMID: 21500856
39. Ge C, Du J, Zhao L, Wang L, Liu Y, Li D, et al Binding of blood proteins to carbon nanotubes reduces cytotoxicity. PNAS. 2011; 108:16968-73. doi: 10.1073/pnas.1105270108 PMID: 21969544
40. Savic R, Luo LB, Eisenberg A, Maysinger D. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science. 2003; 300:615-8. PMID: 12714738