Early antiretroviral therapy in South African children reduces HIV-1-infected cells and cell-associated HIV-1 RNA in blood mononuclear cells

Journal of Infectious Diseases

Volumn 212, Issue 1, 2015, Pages 39-43

  Van Zyl, Gert U ^a,d   Bedison, Margaret A ^b   Van Rensburg, Anita Janse ^c   Laughton, Barbara ^c   Cotton, Mark F ^c   Mellors, John W ^b  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c STELLENBOSCH UNIVERSITY   (South Africa)

^d UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

Early infant antiretroviral therapy; HIV 1 cell associated RNA; HIV 1 cell associated DNA; HIV 1 single copy assay; measures of HIV 1 persistence; transcriptionally active proviruses

Indexed keywords

ABACAVIR; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; VIRUS DNA; VIRUS RNA; ZIDOVUDINE; ANTIRETROVIRUS AGENT;

ARTICLE; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LABORATORY TEST; MONONUCLEAR CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHOOL CHILD; SOUTH AFRICAN; BLOOD; GENETICS; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; SECONDARY PREVENTION; VIROLOGY; VIRUS LOAD;

ANTI-RETROVIRAL AGENTS; BLOOD; CHILD; DNA, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; RNA, VIRAL; SECONDARY PREVENTION; VIRAL LOAD;

EID: 84936804351     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu827     Document Type: Article

References (15)

1. Maldarelli F, Wu X, Su L, et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 2014; 345:179-83.
2. Kearney MF, Spindler J, ShaoW, et al. Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy. PLOS Pathog 2014; 10:e1004010.
3. Stover K, Bock R, National Institute of Allergy and Infectious Diseases. "Mississippi Baby" now has detectable HIV, researchers find. NIH News. 2014.
4. Luzuriaga K, Tabak B, Garber M, et al. Reduced HIV reservoirs after early treatment HIV-1 proviral reservoirs decay continously under sustained virologic control in early-treated HIV-1-infected children. J Infect Dis 2014; 210:1529-38.
5. Cotton MF, Violari A, Otwombe K, et al. Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) randomised trial. Lancet 2013; 382:1555-63.
6. Cillo AR, Krishnan A, Mitsuyasu RT, et al. Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma. J Acquir Immune Defic Syndr 2013; 63:438-41.
7. Cillo AR, Sobolewski MD, Bosch RJ, et al. Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy. Proc Natl Acad Sci USA 2014; 111:7078-83.
8. Cillo AR, Vagratian D, Bedison M, et al. Improved single copy assays for quantification of persistent HIV-1 viremia in patients on suppressive antiretroviral therapy. J Clin Microbiol 2014; 52:3944-51.
9. R Core Team. R: A Language and Environment for Statistical Computing. 2014.
10. Ananworanich J, Puthanakit T, Suntarattiwong P, et al. Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children. AIDS 2014; 28:1015-20.
11. Bitnun A, Samson L, Chun T-W, et al. Early initiation of combination antiretroviral therapy in HIV-1-infected newborn infants can achieve sustained virologic suppression with low frequency of CD4+ T-cells carrying HIV in peripheral blood. Clin Infect Dis 2014; 59:1012-9.
12. Whitney JB, Hill AL, Sanisetty S, et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 2014; 512:74-7.
13. Saéz-Cirión A, Bacchus C, Hocqueloux L, et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLOS Pathog 2013; 9:e1003211.
14. Ho Y-C, Shan L, Hosmane NN, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 2013; 155:540-51.
15. Barouch DH, Whitney JB, Moldt B, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 2013; 503:224-8.