Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma

Journal of Acquired Immune Deficiency Syndromes

Volumn 63, Issue 4, 2013, Pages 438-441

  Cillo, Anthony R ^a   Krishnan, Amrita ^b   Mitsuyasu, Ronald T ^c   McMahon, Deborah K ^a   Li, Shirley ^b   Rossi, John J ^b   Zaia, John A ^b   Mellors, John W ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AIDS related lymphoma; HIV 1 pathogenesis; HIV 1 persistence

Indexed keywords

CARMUSTINE; CELL DNA; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE;

ADULT; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BURKITT LYMPHOMA; CLINICAL ARTICLE; CONFERENCE PAPER; HIV RELATED LYMPHOMA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOMA; MALE; MONONUCLEAR CELL; MULTICENTER STUDY; NONHODGKIN LYMPHOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIREMIA; VIRUS DETECTION;

ADULT; ANTI-RETROVIRAL AGENTS; CROSS-SECTIONAL STUDIES; DNA, VIRAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOMA, AIDS-RELATED; MALE; MIDDLE AGED; MYELOABLATIVE AGONISTS; RNA, VIRAL; TRANSPLANTATION, AUTOLOGOUS; VIRAL LOAD; YOUNG ADULT;

EID: 84880191734     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31828e6163     Document Type: Conference Paper

References (33)

1. Chun TW, Carruth L, Finzi D, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 1997;387:183-188.
2. Wong JK. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science. 1997;278:1291-1295.
3. Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med. 2003;9:727-728.
4. Maldarelli F, Palmer S, King MS, et al. ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathog. 2007;3:e46.
5. Palmer S, Maldarelli F, Wiegand A, et al. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc Natl Acad Sci U S A. 2008;105:3879-3884.
6. Hütter G, Nowak D, Mossner M, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009; 360:692-698.
7. Allers K, Hütter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5D32/D32 stem cell transplantation. Blood. 2011:117:2791-2799.
8. Simard EP, Engels EA. Cancer as a cause of death among people with AIDS in the United States. Clin Infect Dis. 2010;51:957-962.
9. Shiels MS, Pfeiffer RM, Gail MH, et al. Cancer burden in the HIVinfected population in the United States. J Natl Cancer Inst. 2011;103:753-762.
10. Gopal S, Wood WA, Lee SJ, et al. Meeting the challenge of hematologic malignancies in sub-aharan Africa. Blood. 2012;119:5078-5087.
11. Bonnet F, Burty C, Lewden C, et al. Changes in cancer mortality among HIV-infected patients:The Mortalité 2005 survey. Clin Infect Dis. 2009; 48:633-639.
12. Engels EA, Pfeiffer RM, Goedert JJ, et al. Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS. 2006;20:1645-1654.
13. Simard EP, Pfeiffer RM, Engels EA. Cumulative incidence of cancer among individuals with acquired immunodeficiency syndrome in the United States. Cancer. 2010;117:1089-1096.
14. Benicchi T, Ghidini C, Re A, et al. T-cell immune reconstitution after hematopoietic stem cell transplantation for HIV-associated lymphoma. Transplantation. 2005;80:673-682.
15. Krishnan A. Stem cell transplantation in HIV-infected patients. Curr Opin HIV AIDS. 2009;4:11-15.
16. Serrano D, Miralles P, Balsalobre P, et al. Hematopoietic stem cell transplantation in patients infected with HIV. Curr HIV/AIDS Rep. 2010;7:175-184.
17. Michieli M, Mazzucato M, Tirelli U, et al. Stem cell transplantation for lymphoma patients with HIV infection. Cell Transplant. 2011;20:351-370.
18. Mackall CL, Fleisher TA, Brown MR, et al. Lymphocyte depletion during treatment with intensive chemotherapy for cancer. Blood. 1994;84:2221-2228.
19. Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4 + T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med. 1995;332:143-149.
20. Resino S, Pérez A, Seoane E, et al. Short communication:immune reconstitution after autologous peripheral blood stem cell transplantation in HIV-infected patients:might be better than expected? AIDS Res Hum Retroviruses. 2007;23:543-548.
21. Simonelli C, Zanussi S, Pratesi C, et al. Immune recovery after autologous stem cell transplantation is not different for HIV-infected versus HIV-uninfected patients with relapsed or refractory lymphoma. Clin Infect Dis. 2010;50:1672-1679.
22. Palmer S, Wiegand AP, Maldarelli F, et al. New real-time reverse transcriptase- initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol. 2003;41:4531-4536.
23. Besson GJ, McMahon D, Maldarelli F, et al. Short-course raltegravir intensification does not increase 2 long terminal repeat episomal HIV-1 DNA in patients on effective antiretroviral therapy. Clin Infect Dis. 2012; 54:451-453.
24. MalnatiMS, Scarlatti G, Gatto F, et al. A universal real-time PCR assay for the quantification of group-M HIV-1 proviral load. Nat Protoc. 2008:3:1240-1248.
25. Turtle CJ, Swanson HM, Fujii N, et al. A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy. Immunity. 2009;31:834-844.
26. Bolotin E, Annett G, Parkman R, et al. Serum levels of IL-7 in bone marrow transplant recipients:relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant. 1999;23:783-788.
27. Napolitano LA. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion:implications for T-cell homeostasis. Nat Med. 2001;7:73-79.
28. Chomont N, El-Far M, Ancuta P, et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med. 2009;15:893-900.
29. Diviné M, Boutolleau D, Delfau-Farue MH, et al. Poor lymphocyte recovery following CD34-elected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma. Br J Haematol. 1999:105:349-360.
30. Blazar BR, Murphy WJ, Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol. 2012;12:443-458.
31. Henrich TJ, Hu Z, Li JZ, et al. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013;207:1694-1702.
32. Hütter G, Zaia JA. Allogeneic haematopoietic stem cell transplantation in patients with human immunodeficiency virus:The experiences of more than 25 years. Clin Exp Immunol. 2011;163:284-295.
33. Digiusto DL, Krishnan A, Li L, et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34+ cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med. 2010;2:36ra43.